Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis

Heart and Vessels

Volumn 23, Issue 2, 2008, Pages 124-133

  Napoli, Claudio ^a,b   Balestrieri, Maria Luisa ^a   Sica, Vincenzo ^a   Lerman, Lilach O ^c   Crimi, Ettore ^d,e   De Rosa, Gaetano ^e   Schiano, Concetta ^a   Servillo, Luigi ^a   D'Armiento, Francesco P ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antioxidant; Endothelial progenitor cell; Polyphenol; Red wine; Shear stress

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GALLIC ACID; GENE PRODUCT; POLYPHENOL; PROTEIN P JUN; RESVERATROL; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY; DIET SUPPLEMENTATION; DISEASE COURSE; DRUG MECHANISM; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RED WINE; SHEAR STRESS; SHORT COURSE THERAPY; UPREGULATION; VASCULAR ENDOTHELIUM;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ATHEROSCLEROSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ETHANOL; ETS-DOMAIN PROTEIN ELK-1; FLAVONOIDS; HUMANS; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; OXIDATIVE STRESS; PHENOLS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, LDL; SIRTUINS; STRESS, MECHANICAL; WINE;

EID: 41849138655     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-007-1015-8     Document Type: Article

References (54)

1. Szmitko PE, Verma S. Antiatherogenic potential of red wine: Clinician update (2005) Am J Physiol Heart Circ Physiol 288:H2023-H2030
2. Ignarro LJ, Balestrieri ML, Napoli C (2007) Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc Res 73:326-340
3. Djoussé L, Gaziano JM (2007) Alcohol consumption and risk of heart failure in the Physicians' Health Study I. Circulation 115:34-39
4. Sato M, Maulik N, Das DK (2002) Cardioprotection with alcohol: Role of both alcohol and polyphenolic antioxidants. Ann N Y Acad Sci 957:122-135
5. Corder R, Mullen W, Khan NQ, Marks SC, Wood EG, Carrier MJ, Crozier A (2006) Oenology: Red wine procyanidins and vascular health. Nature 444:566
6. Curin Y, Andriantsitohaina R (2005) Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 57:97-107
7. Rakotovao A, Berthonneche C, Guiraud A, de Lorgeril M, Salen P, de Leiris J, Boucher F (2004) Ethanol, wine, and experimental cardioprotection in ischemia/reperfusion: Role of the prooxidant/ antioxidant balance. Antioxid Redox Signal 6:431-438
8. Leikert JF, Rathel TR, Wohlfart P (2002) Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 106:1614-1617
9. Wallerath T, Poleo D, Li H, Forstermann U (2003) Red wine increases the expression of human endothelial nitric oxide synthase. J Am Coll Cardiol 41:471-478
10. Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ (2001) Endothelin-1 synthesis reduced by red wine. Nature 414:863-864
11. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341:454-457
12. Aviram M, Fuhrman B (1998) Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 137:S45-S50
13. Shimada K, Watanabe H, Hosoda K, Takeuchi K, Yoshikawa J (1999) Effect of red wine on coronary flow velocity reserve. Lancet 354:1002
14. da Luz PL, Serrano Junior CV, Chacra AP, Monteiro HP, Yoshida VM, Furtado M, Ferreira S, Gutierrez P, Pileggi F (1999) The effect of red wine on experimental atherosclerosis: Lipid-independent protection. Exp Mol Pathol 65:150-159
15. Vinson JA, Teufel K, Wu N (2001) Red wine, dealcoholised red wine and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis 156:67-72
16. Soulat T, Philippe C, Bal dit Sollier C, Brezillon C, Berge N, Teissedre PL, Callebert J, Rabot S, Drouet L (2006) Wine constituents inhibit thrombosis but not atherogenesis in C57BL/6 apolipoprotein E-deficient mice. Br J Nutr 96:290-298
17. Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A, Aviram M (1997) Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 17:2744-2752
18. Bentzon JF, Skovenborg E, Hansen C, Moller J, de Gaulejac NS, Proch J, Falk E (2001) Red wine does not reduce mature atherosclerosis in apolipoprotein E-deficient mice. Circulation 103:1681-1687
19. Palinski W, Napoli C, Reaven PD (2000) Contemporary cardiology. In: Simon DI, Rogers C (eds) Vascular disease and injury-preclinical research, Harvard Series. Humana, Totowa, NJ, pp 149-174
20. Buga GM, Gold ME, Ignarro LJ (1991) Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 17:187-193
21. Gimbrone MA Jr (1999) Vascular endothelium, hemodynamic forces, and atherogenesis. Am J Pathol 155:1-5
22. Friedman MH, Hutchins GM, Bergerson CB, Deters OJ, Mark FF (1981) Correlation between intimal thickness and fluid shear in human arteries. Atherosclerosis 39:425-436
23. Glagov S, Zarins C, Giddens DP, Ku DN (1988) Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries. Arch Pathol Lab Med 112:1018-1031
24. de Nigris F, Lerman LO, Ignarro SW, Sica G, Lerman A, Palinski W, Ignarro LJ, Napoli C (2003) Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proc Natl Acad Sci USA 100:1420-1425
25. de Nigris F, Ignarro S-W, Lerman LO, Crimi E, Botti C, Mansueto G, D'Armiento FP, De Rosa G, Sica V, Ignaro LJ, Napoli C (2005) Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Proc Natl Acad Sci USA 102:4896-4901
26. Singleton VL, Rossi JA (1965) Colorimetry of total phenols with phosphomolybdic-phosphotungstic acid reagent. Am J Enol Vitic 16:144-158
27. Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP Assay. Anal Biochem 239:70-76
28. Ratola N, Faria JL, Alves A. Analysis and quantification of transresveratrol in wines from Alentejo Region (Portugal) (2004) Food Technol Biotechnol 42:125-130
29. Napoli C, Williams-Ignarro S, De Nigris F, Lerman LO, Rossi L, Guarino C, Mansueto G, Di Tuoro F, Pignalosa O, De Rosa G, Sica V, Ignarro LJ (2004) Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc Natl Acad Sci USA 101:8797-8802
30. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342
31. Bea F, Kreuzer J, Preusch M, Schaab S, Isermann B, Rosenfeld ME, Katus H, Blessing E (2006) Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in Apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26:2787-2792
32. Fuhrman B, Volkova N, Coleman R, Aviram M (2005) Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J Nutr 135:722-728
33. Dufour MC (1999) What is moderate drinking? Defining "drinks" and drinking levels. Alcohol Res Health 23:5-14
34. de Nigris F, Lerman A, Ignarro LJ, Williams-Ignarro S, Sica V, Baker AH, Lerman LO, Geng YJ, Napoli C (2003) Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends Mol Med 9:351-359
35. Yesilbursa D, Serdar A, Senturk T, Serdar Z, Sag S, Cordan J (2006) Effect of N-acetylcysteine on oxidative stress and ventricular function in patients with myocardial infarction. Heart Vessels 21:33-37
36. Orhan G, Yapici N, Yuksel M, Sargin M, Senay S, Yalcin AS, Aykac Z, Aka SA (2006) Effects of N-acetylcysteine on myocardial ischemia-reperfusion injury in bypass surgery. Heart Vessels 21:42-47
37. Chiu JJ, Wung BS, Shyy JY, Hsieh HJ, Wang DL (1997) Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arterioscler Thromb Vasc Biol 17:3570-3577
38. Silacci P, Desgeorges A, Mazzolai L, Chambaz C, Hayoz D (2001) Flow pulsatility is a critical determinant of oxidative stress in endothelial cells. Hypertension 38:1162-1166
39. McCormick SM, Eskin SG, McIntire LV, Teng CL, Lu CM, Russell CG, Chittur KK (2001) DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci USA 98:8955-8960
40. Kroon PA, Clifford MN, Crozier A, Day AJ, Donovan JL, Manach C, Williamson G (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr 80:15-21
41. Ignarro LJ, Cirino G, Napoli C (1999) Nitric oxide as a signaling molecule in the vascular system: An overview. J Cardiovasc Pharmacol 34:879-886
42. Napoli C, de Nigris F, Williams-Ignarro S, Pignalosa O, Sica V, Ignarro LJ (2006) Nitric oxide and atherosclerosis: An update. Nitric Oxide 15:265-279
43. Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB (2005) Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J 19:455-457
44. Gambuti A, Strollo D, Ugliano M, Lecce L, Moio L (2004) trans-Resveratrol, quercetin, (+)-catechin, and (-)-epicatechin content in south Italian monovarietal wines: Relationship with maceration time and marc pressing during winemaking. J Agric Food Chem 52:5747-5751
45. Cheynier V (2005) Polyphenols in foods are more complex than often thought. Am J Clin Nutr 81:223S-229S
46. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G (2000) Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 342:454-460
47. Napoli C, Stanley WC, Ignarro LJ (2007) Nutrition and Cardiovascular disease: Pathogenic framework into focus. Cardiovasc Res 73:253-256
48. Napoli C, Williams-Ignarro S, de Nigris F, Lerman LO, D'Armiento FP, Crimi E, Byrns RE, Casamassimi A, Lanza A, Gombos F, Sica V, Ignarro LJ (2006) Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice. Proc Natl Acad Sci USA 103:10479-10484
49. Avellone G, Di Garbo V, Campisi D, De Simone R, Raneli G, Scaglione R, Licata G (2006) Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. Eur J Clin Nutr 60:41-47
50. Hozumi T, Sugioka K, Shimada K, Kim SH, Kuo MY, Miyake Y, Fujimoto K, Otsuka R, Watanabe H, Hosoda K, Yoshikawa J, Homma S (2006) Beneficial effect of short-term intake of red wine polyphenols on coronary microcirculation in patients with coronary artery disease. Heart 92:681-682
51. Arendt BM, Ellinger S, Kekic K, Geus L, Fimmers R, Spengler U, Muller WU, Goerlich R (2005) Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: A randomized controlled trial (ISRCTN68505294). Nutr J 4:33
52. Guarda E, Godoy I, Foncea R, Perez DD, Romero C, Venegas R, Leighton F (2005) Red wine reduces oxidative stress in patients with acute coronary syndrome. Int J Cardiol 104:35-38
53. Goldberg IJ, Mosca L, Piano MR, Fisher EA; Nutrition Committee, Council on Epidemiology and Prevention; Council on Cardiovascular Nursing of the American Heart Association (2001) AHA Science Advisory: wine and your heart: A science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Association. Circulation 103:472-475
54. Napoli C, Lerman LO, de Nigris F, Goessl M, Balestrieri ML, Lerman A (2006) Rethinking primary prevention of atherosclerosis-related diseases Circulation 114:2517-2527