Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations

Molecular Systems Biology

Volumn 10, Issue 5, 2014, Pages

  Kiel, Christina ^a,b   Serrano, Luis ^a,b,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

enedgetics; FoldX; MAPK pathway; missense mutations; RASopathy

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROLACTIN RECEPTOR; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ALGORITHM; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; DEREGULATION; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; GENETIC ANALYSIS; GERMLINE MUTATION; HUMAN; IN VITRO STUDY; JUVENILE MYELOMONOCYTIC LEUKEMIA; MISSENSE MUTATION; NEOPLASM; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RASOPATHY; SIGNAL TRANSDUCTION; SOMATIC MUTATION; GENETICS; METABOLISM;

HUMANS; METABOLIC NETWORKS AND PATHWAYS; MUTATION, MISSENSE; NEOPLASMS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 84901623181     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1002/msb.20145092     Document Type: Article

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