A detailed thermodynamic analysis of Ras/effector complex interfaces

Journal of Molecular Biology

Volumn 340, Issue 5, 2004, Pages 1039-1058

  Kiel, Christina ^a   Serrano, Luis ^b   Herrmann, Christian ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

double mutant cycle; energy calculation; GDI, guanine nucleotide dissociation inhibition; GppNHp, guanosine 5 ( , imido) triphosphate; protein protein interaction; Ras effector interfaces; thermodynamic analysis

Indexed keywords

ALANINE; AMINO ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; RAF PROTEIN; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR PROTEIN; RAL PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALORIMETRY; CELL FUNCTION; COMPUTER PROGRAM; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ELECTRICITY; ENTHALPY; ENTROPY; ESCHERICHIA COLI; FLUORESCENCE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS;

EID: 3242797452     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.05.050     Document Type: Article

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