Cell type-specific importance of Ras-c-Raf complex association rate constants for mapk signaling

Science Signaling

Volumn 2, Issue 81, 2009, Pages

  Kiel, Christina ^a   Serrano, Luis ^a,b  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C RAF PROTEIN; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P21; SOS PROTEIN;

ARTICLE; BINDING AFFINITY; CELL TYPE; COMPUTER SIMULATION; DISSOCIATION CONSTANT; EMBRYO CELL; KIDNEY PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOBLOTTING; KINETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE; TIME;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BINDING SITES; CELL LINE; COMPUTER SIMULATION; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNOBLOTTING; KINETICS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTOR, EPIDERMAL GROWTH FACTOR; SOS1 PROTEIN; SPECIES SPECIFICITY; TIME FACTORS; TRANSFECTION;

EID: 70350452750     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000397     Document Type: Article

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43. We thank N. Kuemmerer for help with mutagenesis and cell culture, B. N. Kholodenko and W. Kolch for critical reading of the manuscript, and F. Wittinghofer, M. Ueffing, and W. Kolch for valuable discussions and for providing many plasmids used in this work. The work was supported by the European Union (INTERACTION proteome, grant LSHG-CT-2003-505520).