Endothelial barrier protection by local anesthetics: Ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation

Anesthesiology

Volumn 120, Issue 6, 2014, Pages 1414-1428

  Piegeler, Tobias ^a,c   Votta Velis, E Gina ^a,f,g   Bakhshi, Farnaz R ^a   Mao, Mao ^a   Carnegie, Graeme ^a   Bonini, Marcelo G ^a   Schwartz, David E ^a   Borgeat, Alain ^e   Beck Schimmer, Beatrice ^d   Minshall, Richard D ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS HOSPITAL AND HEALTH SCIENCES SYSTEM   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Institute of Anesthesiology University Hospital Zurich ^*  (United States)

^f BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^g JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; LIDOCAINE; LOCAL ANESTHETIC AGENT; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN TYROSINE KINASE; ROPIVACAINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL PERMEABILIZATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; MONOLAYER CULTURE; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMIDES; ANESTHETICS, LOCAL; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; LIDOCAINE; LUNG; MICROCIRCULATION; SRC-FAMILY KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901620675     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000174     Document Type: Article

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