TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant

Biochemistry

Volumn 51, Issue 33, 2012, Pages 6545-6555

  Lewis, Andrew K ^a   Valley, Christopher C ^a   Sachs, Jonathan N ^a  

^a University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACKBONE DYNAMICS; CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; CONSTITUTIVELY ACTIVES; CYTOSOLIC DOMAINS; DYNAMIC COUPLINGS; HIGH MOLECULAR WEIGHT; INTRACELLULAR SIGNALING; LIGAND BINDING; LIGAND-INDEPENDENT SIGNALING; LIGAND-RECEPTOR; NETWORK FORMATION; NORMAL MODE ANALYSIS; RECEPTOR ACTIVATION; STRUCTURAL CHANGE; TRIMERIZATION; TUMOR NECROSIS FACTORS; WILD TYPES;

ACTIVATION ANALYSIS; DIMERS; LIGANDS; SIGNALING;

BIOACTIVITY;

DIMER; TUMOR NECROSIS FACTOR RECEPTOR 1;

ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; RECEPTOR UPREGULATION; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PERIODIC SYNDROME; WILD TYPE;

FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HEREDITARY AUTOINFLAMMATORY DISEASES; HUMANS; LIGANDS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION;

EID: 84865411840     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3006626     Document Type: Article

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