Complex blockade of TTX-resistant Na+ currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons

Journal of Neurophysiology

Volumn 79, Issue 4, 1998, Pages 1746-1754

  Scholz, Andreas ^a   Kuboyama, Noboru ^b   Hempelmann, Gunter ^c   Vogel, Werner ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b NIHON UNIVERSITY   (Japan)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BUPIVACAINE; LIDOCAINE; SODIUM CHANNEL;

ANALGESIA; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; ION TRANSPORT; KINETICS; MALE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL STIMULATION; NERVE CONDUCTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SODIUM CURRENT; SPINAL ANESTHESIA; SPINAL GANGLION;

EID: 0031897624     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.79.4.1746     Document Type: Article

References (29)

1. AKOPIAN, A. N., SIVILOTTI, L., AND WOOD, J. N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 257-262, 1996.
2. BEAN, B. P., COHEN, C. J., AND TSIEN, R. W. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81: 613-642, 1983.
3. CARBONE, E. AND LUX. H. D. Omega-conotoxin blockade distinguishes Ca from Na permeable states in neuronal calcium channels. Pflügers Arch. 413: 14-22, 1988.
4. CHANDLER, W. K. AND MEVES, H. Slow changes in membrane permeability and long-lasting action potentials in axons perfused with fluonde solutions. J. Physiol. (Lond.) 211: 707-728, 1970.
5. DENNHARDT, R. AND KONDER, H. Blood and cerebrospinal fluid levels of bupivacaine in spinal anesthesia (in German). Reg. Anaesth. 6: 72-75, 1983.
6. ELUOTT, A. A. AND ELLIOTT, J. R. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia J. Physiol. (Lond.) 463: 39-56, 1993.
7. GISSEN, A. J., COVINO, B. G., AND GREGUS, J. Differential sensitivities of mammalian nerve fibers to local anesthetic agents. Anesthesiology 53: 467-474, 1980.
8. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B., AND SIGWORTH, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100, 1981.
9. HARPER, A. A. AND LAWSON, S. N. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J. Physiol. (Lond.) 359: 31-46, 1985a.
10. HARPER, A. A. AND LAWSON, S. N. Electrical properties of rat dorsal root ganglion neurones with different peripheral nerve conduction velocities. J. Physiol. (Lond.) 359: 47-63, 1985b.
11. HESS, P., LANSMAN, J. B., AND TSIEN, R. W. Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J. Gen. Physiol. 88:293-319, 1986.
12. HILLE, B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69: 497-515, 1977.
13. JEFTINIJA, S. The role of tetrodotoxin-resistant sodium channels of small primary afferent fibers. Brain Res. 639: 125-134, 1994.
14. KOSTYUK, P. G., KRISHTAL, O. A., AND PIDOPLICHKO, V. I. Asymmetrical displacement currents in nerve cell membrane and effect of internal fluoride. Nature 267: 70-72, 1977.
15. KOSTYUK, P. G. VESELOVSKY, N. S., AND TSYNDRENKO, A. Y. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents. Neuroscience 6: 2423-2430, 1981.
16. MADEJA, M. MUSSHOFF, U., AND SPECKMANN, E. J. Follicular tissues reduce drug effects on ion channels in oocytes of Xenopus laevis. Eur. J. Neurosci. 9: 599-604, 1997.
17. MINTZ, I. M., ADAMS, M. E., AND BEAN, B. P. P-type calcium channels in rat central and peripheral neurons. Neuron 9: 85-95, 1992.
18. + channels in rat dorsal root ganglia. J. Physiol. (Lond.) 466: 9-37 1993.
19. QUASTHOFF, S., GROSSKREUTZ, J., SCHRODER, J. M., SCHNEIDER, U., AND GRAFE, P. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neuroscience 69: 955-965, 1995.
20. + channels by local anesthetics. Science 265: 1724-1728, 1994.
21. RAYMOND, S. A. AND GISSEN, A. J. Mechanisms of differential nerve block. In: Local Anesthetics, edited by G. R. Strichartz. Berlin: Springer-Verlag, 1987, p.95-165.
22. ROY, M. L. AND NARAHASHI, T. Differential properties of tetrodotoxinsensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12: 2104-2111, 1992.
23. + channels and their functions in small dorsal root ganglion neurones of rat J. Physiol. (Lond.) 493: 393-408, 1996.
24. SCHMIDTMAYER, J. AND ULBRICHT, W. Interaction of lidocame and benzocaine in blocking sodium channels. Pflügers Arch. 387: 47-54, 1980.
25. SCHOLZ, A., APPEL, N., AND VOGEL, W. R-and Q-type Ca-channels in rat dorsal root ganglion neurones. Pflügers Arch. 433: R143, 1997.
26. +-channels in rat dorsal root ganglion neurones (Abstract). Pflügers Arch. 431: R83, 1996.
27. SCHOLZ, A., REID G., VOGEL, W., AND BOSTOCK, H. Ion channels in human axons. J. Neurophysiol. 70: 1274-1279, 1993.
28. ULBRICHT, W. Kinetics of drug action and equilibrium results at the node of Ranvier. Physiol. Rev. 61: 785-828, 1981.
29. WILDSMITH, J. A., BROWN, D. T., PAUL, D., AND JOHNSON S. Structure-activity relationships in differential nerve block at high and low frequency stimulation. Br. J. Anaesth. 63: 444-452, 1989.