Fluidizing the Membrane by a Local Anesthetic: Phenylethanol Affects Membrane Protein Oligomerization

Journal of Molecular Biology

Volumn 404, Issue 5, 2010, Pages 773-777

  Anbazhagan, Veerappan ^a,b   Munz, Carmen ^b   Tome, Lydia ^a   Schneider, Dirk ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anesthetic; Glycophorin A; Helix helix interaction; Membrane; TOXCAT

Indexed keywords

1,2 DIEICOSENOYLGLYCERO 3 PHOSPHOCHOLINE; CHOLINE DERIVATIVE; DIMER; DIMYRISTOYLPHOSPHATIDYLCHOLINE; GLYCOPHORIN A; LAURDAN; PHENETHYL ALCOHOL; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANESTHESIA MECHANISM; ANIMAL CELL; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; DIMERIZATION; ESCHERICHIA COLI; HUMAN; LIPID BILAYER; MEMBRANE FLUIDITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ESCHERICHIA COLI;

EID: 78649529371     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.10.026     Document Type: Article

References (17)

1. Franks N.P. Molecular targets underlying general anaesthesia. Br. J. Pharmacol. 2006, 147:S72-S81.
2. Cantor R.S. Lateral pressures in cell membranes: a mechanism for modulation of protein function. J. Phys. Chem. B 1997, 101:1723-1725.
3. Heimburg T., Jackson A.D. The thermodynamics of general anesthesia. Biophys. J. 2007, 92:3159-3165.
4. Mackenzie K.R. Folding and stability of alpha-helical integral membrane proteins. Chem. Rev. 2006, 106:1931-1977.
5. Cymer F., Schneider D. Transmembrane helix-helix interactions involved in ErbB receptor signaling. Cell Adhes. Migr. 2010, 4:299-312.
6. Li E., Hristova K. Receptor tyrosine kinase transmembrane domains: function, dimer structure and dimerization energetics. Cell Adhes. Migr. 2010, 4:249-254.
7. MacKenzie K.R., Prestegard J.H., Engelman D.M. A transmembrane helix dimer: structure and implications. Science 1997, 276:131-133.
8. Anbazhagan V., Cymer F., Schneider D. Unfolding a transmembrane helix dimer: a FRET study in mixed micelles. Arch. Biochem. Biophys. 2010, 495:159-164.
9. You M., Li E., Wimley W.C., Hristova K. Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment. Anal. Biochem. 2005, 340:154-164.
10. Anbazhagan V., Schneider D. The membrane environment modulates self-association of the human GpA TM domain-implications for membrane protein folding and transmembrane signaling. Biochim. Biophys. Acta 2010, 1798:1899-1907.
11. Parasassi T., De Stasio G., d'Ubaldo A., Gratton E. Phase fluctuation in phospholipid membranes revealed by Laurdan fluorescence. Biophys. J. 1990, 57:1179-1186.
12. Russ W.P., Engelman D.M. TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc. Natl Acad. Sci. USA 1999, 96:863-868.
13. Finger C., Escher C., Schneider D. The single transmembrane domains of human receptor tyrosine kinases encode self-interactions. Sci. Signaling 2009, 2:ra56.
14. Hubbard S.R., Miller W.T. Receptor tyrosine kinases: mechanisms of activation and signaling. Curr. Opin. Cell. Biol. 2007, 19:117-123.
15. Riven I., Iwanir S., Reuveny E. GIRK channel activation involves a local rearrangement of a preformed G protein channel complex. Neuron 2006, 51:561-573.
16. Rosenbaum D.M., Rasmussen S.G., Kobilka B.K. The structure and function of G-protein-coupled receptors. Nature 2009, 459:356-363.
17. Jerabek H., Pabst G., Rappolt M., Stockner T. Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine. J. Am. Chem. Soc. 2010, 132:7990-7997.