A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

Circulation Research

Volumn 111, Issue 12, 2012, Pages 1517-1527

  Naikawadi, Ram P ^a   Cheng, Ni ^a   Vogel, Stephen M ^a   Qian, Feng ^a   Wu, Dianqing ^b   Malik, Asrar B ^a   Ye, Richard D ^a,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

acute lung injury; endothelial dysfunction; guanine nucleotide exchange factors; pulmonary edema; reactive oxygen species; small GTPases; vascular permeability

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE DEPENDENT RAC EXCHANGER 1; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM; GENE DELETION; HUMAN; HUMAN CELL; LUNG EDEMA; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VASCULAR HYPERPERMEABILITY;

ANIMALS; CAPILLARY PERMEABILITY; CELL LINE; ENDOTHELIUM, VASCULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HL-60 CELLS; HUMANS; MICE; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84871544837     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.273078     Document Type: Article

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