Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway

Free Radical Biology and Medicine

Volumn 52, Issue 2, 2012, Pages 427-435

  Mao, Mao ^a   Sudhahar, Varadarajan ^a   Ansenberger Fricano, Kristine ^a   Fernandes, Denise C ^b   Tanaka, Leonardo Y ^b   Fukai, Tohru ^a   Laurindo, Francisco R M ^b   Mason, Ronald P ^c   Vasquez Vivar, Jeannette ^d   Minshall, Richard D ^e   Stadler, Krisztian ^c   Bonini, Marcelo G ^a,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Akt; eNOS; Free radicals; Glyceryl trinitrate; Nitric oxide; Nitroglycerin; PI3K

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCERYL TRINITRATE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANDROSTADIENES; ANIMALS; AORTA; BLOOD PRESSURE; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; MALE; MICE; MICROVESSELS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITROGLYCERIN; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VASODILATION; VASODILATOR AGENTS;

ANGINA;

EID: 84855460214     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.09.020     Document Type: Article

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