Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate

European Journal of Clinical Pharmacology

Volumn 67, Issue 4, 2011, Pages 399-406

  Cusato, Maria ^a   Allegri, Massimo ^a   Niebel, Tekla ^a,b   Ingelmo, Pablo ^c   Broglia, Monica ^a   Braschi, Antonio ^a,b   Regazzi, Mario ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c SAN GERARDO HOSPITAL   (Italy)

Author keywords

Drug accumulation; Drug exposure; Flip flop kinetics; Pharmacokinetics; Ropivacaine

Indexed keywords

CISATRACURIUM; FENTANYL; PROPOFOL; ROPIVACAINE; SUFENTANIL;

ABDOMINAL SURGERY; ADULT; ANESTHESIA INDUCTION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; CONVULSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FACE DISORDER; FACIAL DYSTHESIA; FEMALE; HALLUCINATION; HEART ARRHYTHMIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOTENSION; LOADING DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; PLASMA CONCENTRATION-TIME CURVE; POSTOPERATIVE ANALGESIA; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TINNITUS; ULTRAVIOLET RADIATION; UROLOGIC SURGERY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AMIDES; ANESTHETICS, LOCAL; AREA UNDER CURVE; FEMALE; HALF-LIFE; HUMANS; INJECTIONS, EPIDURAL; MALE; MIDDLE AGED; MODELS, STATISTICAL;

EID: 79954577239     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0927-x     Document Type: Article

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