15-Deoxy-Δ12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells

Prostaglandins and Other Lipid Mediators

Volumn 109-111, Issue , 2014, Pages 1-13

  Sakaba, Yukiko ^a   Awata, Hisataka ^a   Morisugi, Toshiaki ^b   Kawakami, Tetsuji ^b   Sakudo, Akikazu ^a   Tanaka, Yasuharu ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Caspase; p53; PPAR ; Synovial

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ACETYLCYSTEINE; CASPASE 3; CASPASE 9; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; CASPASE 7; CYTOKINE; PROSTAGLANDIN D2;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; COVALENT BOND; CYTOTOXICITY ASSAY; DNA FRAGMENTATION; ENZYME ACTIVATION; FIBROBLAST; GENETIC TRANSFECTION; IN VITRO STUDY; NONHUMAN; RABBIT; REPORTER GENE; SYNOVIOCYTE; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; SOLUBILITY; SYNOVIAL FLUID;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE; CYTOKINES; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; PPAR GAMMA; PROSTAGLANDIN D2; RABBITS; SIGNAL TRANSDUCTION; SOLUBILITY; SYNOVIAL FLUID; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84901587523     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2014.02.001     Document Type: Article

References (71)

1. D.S. Straus, and C.K. Glass Cyclopentenone prostaglandins: new insights on biological activities and cellular targets Med Res Rev 21 2001 185 210 (Pubitemid 32303994)
2. 2: an electrophilic trigger of cellular responses Chem Res Toxicol 21 2008 138 144 (Pubitemid 351219715)
3. 2 for induction of human articular chondrocyte apoptosis in arthritis J Biol Chem 279 2004 37939 37950 (Pubitemid 39195509)
4. 2 is a ligand or the adipocyte determination factor PPARγ Cell 83 1995 803 812 (Pubitemid 3006324)
5. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Cell 83 1995 813 819 (Pubitemid 3006325)
6. 2 inhibition of NF-κB-DNA binding through covalent modification of the [50p] subunit J Biol Chem 276 2001 35530 35536
7. 2 inhibits multiple steps in the NF-κB signaling pathway Proc Natl Acad Sci USA 97 2000 4844 4849 (Pubitemid 30238645)
8. 2 J Biol Chem 278 2003 51251 51260 (Pubitemid 38020362)
9. 2 impairs the functions of histone acetyltransferases through their insolubilization in cells Biochem Biophys Res Commun 390 2009 290 294
10. 2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity Clin Cancer Res 15 2009 5414 5425
11. 2: the endogenous electrophile that induces neuronal apoptosis Proc Natl Acad Sci USA 99 2002 7367 7372 (Pubitemid 34568697)
12. 2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism Carcinogenesis 26 2005 81 92 (Pubitemid 40207702)
13. 2 via ROS formation: an alternative pathway without PPARγactivation in non-small cell lung carcinoma A549 cells Prostaglandins Other Lipid Mediat 94 2011 104 111
14. H.A. Elrod, and S.Y. Sun PPARγ and apoptosis in cancer PPAR Res 2008 2008 Article ID 704165
15. M.B. Goldring, and M. Otero Inflammation in osteoarthritis Curr Opin Rheumatol 23 2011 471 478
16. J. Sellam, and F. Berenbaum The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis Nat Rev Rheumatol 6 2010 625 635
17. S. Sutton, A. Clutterbuck, and P. Harris et al. The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis Vet J 179 2009 10 24
18. M. Attur, J. Samuels, S. Krasnokutsky, B. Steven, and S.B. Abramson Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence? Best Pract Res Clin Rheumatol 24 2010 71 79
19. H.L. Pahl Activators and target genes of Rel/NF-κB transcription factors Oncogene 18 1999 6853 6866
20. K.B. Marcu, M. Otero, E. Olivotto, R.M. Borzi, and M.B. Goldring NF-κB signaling: multiple angles to target OA Curr Drug Targets 11 2010 599 613
21. D. Khanna, G. Sethi, and K.S. Ahn et al. Natural products as a gold mine for arthritis treatment Curr Opin Pharmacol 7 2007 344 351 (Pubitemid 46731200)
22. J.A. Roman-Blas, and S.A. Jimenez NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis Osteoarthritis Cartilage 14 2006 839 848 (Pubitemid 44138675)
23. 2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats J Clin Invest 106 2000 189 197 (Pubitemid 30483122)
24. W.H. Cho, C.H. Choi, J.Y. Park, S.K. Kang, and Y.K. Kim 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells Neurochem Res 31 2006 1247 1254 (Pubitemid 44701772)
25. 2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts J Biol Chem 279 2004 22399 22403 (Pubitemid 38679437)
26. S. Cheng, H. Afif, and J. Martel-Pelletier et al. Activation of peroxisome proliferator-activated receptor γ inhibits interleukin-1β- induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1 J Biol Chem 279 2004 22057 22065 (Pubitemid 38679397)
27. 2 through a histone deacetylase-independent mechanism Arthritis Rheum 52 2005 94 104 (Pubitemid 40129237)
28. T.H. Lin, C.H. Tang, K. Wu, Y.C. Fong, R.S. Yang, and W.M. Fu 15-Deoxy-Δ12,14-prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts J Cell Physiol 226 2011 3242 3250
29. T. Morisugi, Y. Tanaka, T. Kawakami, and T. Kirita Mechanical stretch enhances NF-κB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells J Biochem 147 2010 633 644
30. N.A. Thornberry, T.A. Rano, and E.P. Peterson et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B: functional relationships established for key mediators of apoptosis J Biol Chem 272 1997 17907 17911 (Pubitemid 27306365)
31. H. Zhu, H.O. Fearnhead, and G.M. Cohen An ICE like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells FEBS Lett 374 1995 303 308
32. O.K. Mirzoeva, P. Yaqoob, K.A. Knox, and P.C. Calder Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis FEBS Lett 396 1996 266 270 (Pubitemid 26377837)
33. J. Prakash, R. Bansal, E. Post, A. de Jager-Krikken, M.N. Lub-de Hooge, and K. Poelstra Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Δ12,14-prostaglandin-J2 Neoplasia 11 2009 1348 1358
34. M. Ahmadian, J.M. Suh, and N. Hah et al. PPARγ signaling and metabolism: the good, the bad and the future Nat Med 19 2013 557 566
35. Y. Tanaka, K. Ota, M. Kameoka, A. Itaya, and K. Yoshihara Up-regulation of NFκB-responsive gene expression by ΔNp73α in p53 null cells Exp Cell Res 312 2006 1254 1264
36. Y. Tanaka, M. Kameoka, K. Ota, A. Itaya, K. Ikuta, and K. Yoshihara Establishment of persistent infection with HIV-1 abrogates the caspase-3-dependent apoptotic signaling pathway in U937 cells Exp Cell Res 247 1999 514 524 (Pubitemid 29394789)
37. A. Rodríguez-Hernández, G. Brea-Calvo, D.J.M. Fernández-Ayala, M. Cordero, P. Navas, and J.A. Sánchez- Alcázar Nuclear caspase-3 and capase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis Apoptosis 11 2006 131 139 (Pubitemid 43151651)
38. S. Nagata, H. Nagase, K. Kawane, N. Mukae, and H. Fukuyama Degradation of chromosomal DNA during apoptosis Cell Death Differ 10 2003 108 116 (Pubitemid 36511836)
39. T.M. Willson, P.J. Brown, D.D. Sternbach, and B.R. Henke The PPARs: from orphan receptors to drug discovery J Med Chem 43 2000 527 550 (Pubitemid 30127149)
40. M. Kondo, T. Oya-Ito, T. Kumagai, T. Osawa, and K. Uchida Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress J Biol Chem 276 2001 12076 12083
41. L. Li, J. Tao, and J. Davaille et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts: a pathway involving oxidative stress independently of peroxisome-proliferator activated receptors J Biol Chem 276 2001 38152 38158
42. 2 induces apoptosis via JNK-mediated mitochondrial pathway in osteoblastic cells Toxicology 248 2008 121 129
43. G.C. Yen, P.D. Duh, and C.W. Lin Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes Free Radic Res 37 2003 509 514
44. 2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis Biochem Pharmacol 77 2009 337 347
45. D.D. Rees, R.M.J. Palmer, R. Schulz, H.F. Hodson, and S. Moncada Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo Br J Pharmacol 101 1990 746 752 (Pubitemid 20357206)
46. R. Stocker, Y. Yamamoto, A.F. McDonagh, A.N. Glazer, and B.N. Ames Bilirubin is an antioxidant of possible physiological importance Science 235 1987 1043 1046 (Pubitemid 17049750)
47. T. Jansen, M. Hortmann, and M. Oelze et al. Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1: evidence for direct and indirect antioxidant actions of bilirubin J Mol Cell Cardiol 49 2010 186 195
48. I. Perez-Cruz, J.M. Carcamo, and D.W. Golde Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells Blood 102 2003 336 343 (Pubitemid 36759674)
49. G.W. Burton, A. Joyce, U. Keith, and K.U. Ingold Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch Biochem Biophys 221 1983 281 290 (Pubitemid 13128239)
50. L. Lindenboim, C. Borner, and R. Stein Nuclear proteins acting on mitochondria Biochim Biophys Acta 1813 2011 584 596
51. T.C. Ho, S.L. Chen, and Y.C. Yang et al. 15-Deoxy-Δ(12,14)- prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53 J Biol Chem 283 2008 30273 30288
52. M. Kobayashi, H. Ono, and K. Mihara et al. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin Genes Cells 11 2006 779 789 (Pubitemid 43923349)
53. 2 response of normal human fibroblasts Biochem J 347 2000 543 551 (Pubitemid 30229403)
54. P.J.M. Murphy, M.D. Galigniana, and Y. Morishima et al. Pifithrin-α inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation J Biol Chem 279 2004 30195 30201 (Pubitemid 38937944)
55. D. Vucic, V.M. Dixit, and I.E. Wertz Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death Nat Rev Mol Cell Biol 12 2011 439 452
56. B. Díez-Dacal, and D. Pérez-Sala Anti-inflammatory prostanoids: focus on the interactions between electrophile signaling and resolution of inflammation ScientificWorldJournal 10 2010 655 675
57. H. Shen, and V. Tergaonkar NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy Apoptosis 14 2009 348 363
58. D.M. Ray, F. Akbiyik, and R.P. Phipps The peroxisome proliferator- activated receptor γ (PPARγ) ligands 15-deoxy-Δ12,14- prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARγ-independent mechanisms J Immunol 177 2006 5068 5076 (Pubitemid 44527577)
59. L.A. Pradelli, M. Bénéteau, and J.E. Ricci Mitochondrial control of caspase-dependent and -independent cell death Cell Mol Life Sci 67 2010 1589 1597
60. I. Chowdhury, B. Tharakan, and G.K. Bhat Caspases - an update Comp Biochem Physiol B151 2008 10 27
61. A. Nencioni, K. Lauber, and F. Grünebach et al. Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling J Immunol 171 2003 5148 5156 (Pubitemid 37432798)
62. 2 in mitochondria Biochem J 394 2006 185 195 (Pubitemid 43259668)
63. E.M. Brunoldi, G. Zanoni, and G. Vidari et al. Cyclopentenone prostaglandin, 15-deoxy-Δ12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione Chem Res Toxicol 20 2007 1528 1535 (Pubitemid 350057223)
64. B.S. Wung, C.C. Wu, M.C. Hsu, and C.W. Hsieh 15-Deoxy-Δ12,14- prostaglandin J2 suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells Life Sci 78 2006 3035 3042
65. G. Olmos, I. Conde, and I. Arenas et al. Accumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism Cell Signal 19 2007 2098 2105 (Pubitemid 47353813)
66. R. Kim, M. Emi, and K. Tanabe Role of mitochondria as the gardens of cell death Cancer Chemother Pharmacol 57 2006 545 553 (Pubitemid 43237837)
67. D.H. Kim, E.H. Kim, H.K. Na, and Y.J. Surh Effects of 15-deoxy-Δ12,14-prostaglandin J2 on the expression of p53 in MCF-7 cells Ann NY Acad Sci 1171 2009 202 209
68. P.J. Moos, K. Edes, P. Cassidy, E. Massuda, and F.A. Fitzpatrick Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase J Biol Chem 278 2003 745 750 (Pubitemid 36790745)
69. J.E. Mullally, P.J. Moos, K. Edes, and F.A. Fitzpatrick Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway J Biol Chem 276 2001 30366 30373
70. D.H. Kim, E.H. Kim, H.K. Na, Y. Sun, and Y.J. Surh 15-Deoxy-Δ12,14- prostaglandin J2 stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue Oncogene 29 2010 2560 2576
71. T. Shibata, T. Yamada, and M. Kondo et al. An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Δ12,14-prostaglandin J2 on proteasome Biochemistry 42 2003 13960 13968 (Pubitemid 37466621)