15-Deoxy-Δ-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism

Carcinogenesis

Volumn 26, Issue 1, 2005, Pages 81-92

  Pignatelli, Miguel ^a   Sánchez Rodríguez, Jinny ^a,b   Santos, Angel ^c   Perez Castillo, Ana ^a  

^a CSIC   (Spain)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ASCORBIC ACID; CASPASE; CYTOCHROME C; EBSELEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLSERINE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; ROTENONE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXYGEN CONSUMPTION; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN TARGETING; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; HUMANS; MICROSCOPY, CONFOCAL; MICROTUBULES; MITOCHONDRIA; OXYGEN CONSUMPTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROSTAGLANDINS; REACTIVE OXYGEN SPECIES;

EID: 13444292545     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh308     Document Type: Article

References (51)

1. Fitzpatrick,F.A. and Wynalda,M.A. (1983) Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J. Biol. Chem., 258, 11713-11718.
2. Straus,D.S. and Glass,C.K. (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med. Res. Rev., 21, 185-210.
3. Kersten,S., Desvergne,B. and Wahli,W. (2000) Roles of PPARS in health and disease. Nature, 405, 421-424.
4. Kliewer,S.A., Lenhard,J.M., Willson,T.M., Patel,I., Morris,D.C. and Lehmann,J.M. (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell, 83, 813-819.
5. Schoonjans,K., Staels,B. and Auwerx,J. (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta, 1302, 93-109.
6. Kliewer,S.A. and Willson,T.M. (1998) The nuclear receptor PPARgamma - bigger than fat. Curr. Opin. Genet. Dev., 8, 576-581.
7. Rosen,E.D. and Spiegelman,B.M. (2001) PPARgamma: a nuclear regulator of metabolism, differentiation and cell growth. J. Biol. Chem., 276, 37731-37734.
8. Debril,M.B., Renaud,J.P., Fajas,L. and Auwerx,J. (2001) The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J. Mol. Med., 79, 30-47.
9. Tontonoz,P., Singer,S., Forman,B.M. et al. (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc. Natl Acad. Sci. USA, 94, 237-241.
10. Sarraf,P., Mueller,E., Jones,D. et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nature Med., 4, 1046-52.
11. Elstner,E., Muller,C., Koshizuka,K., Williamson,E.A., Park,D., Asou,H., Shintaku,P., Said,J.W., Heber,D. and Koeffler,H.P. (1998) Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl Acad. Sci. USA, 95, 8806-8811.
12. Pignatelli,M., Cortes-Canteli,M., Lai,C., Santos,A. and Perez-Castillo,A. (2001) The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. J. Cell Sci., 114, 4117-4126.
13. Yin,F., Wakino,S., Liu,Z., Kim,S., Hsueh,W.A., Collins,A.R., Van Herle,A.J. and Law,R.E. (2001) Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators. Biochem. Biophys. Res. Commun., 286, 916-922.
14. Kawahito,Y., Kondo,M., Tsubouchi,Y., Hashiramoto,A., Bishop-Bailey,D., Inoue,K., Kohno,M., Yamada,R., Hla,T. and Sano,H. (2000) 15-Deoxy-delta (12,14)-PGJ (2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J. Clin. Invest., 106, 189-197.
15. Bishop-Bailey,D. and Hla,T. (1999) Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12, 14-prostaglandin J2. J. Biol. Chem., 274, 17042-17048.
16. Chinetti,G., Griglio,S., Antonucci,M., Torra,I.P., Delerive,P., Majd,Z., Fruchart,J.C., Chapman,J., Najib,J. and Staels,B. (1998) Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem., 273, 25573-23380.
17. Harris,S.G. and Phipps,R.P. (2002) Prostaglandin D (2), its metabolite 15-d-PGJ (2) and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. Immunology, 105, 23-34.
18. Padilla,J., Kaur,K., Cao,H.J., Smith,T.J. and Phipps,R.P. (2000) Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-delta (12,14) (12,14)-PGJ (2) induce apoptosis in normal and malignant B-lineage cells. J. Immunol., 165, 6941-6948.
19. Clay,C.E., Namen,A.M., Fonteh,A.N., Atsumi,G., High,K.P. and Chilton,F.H. (2000) 15-Deoxy-delta (12,14)PGJ (2) induces diverse biological responses via PPARgamma activation in cancer cells. Prostaglandins Other Lipid Mediat., 62, 23-32.
20. Clay,C.E., Atsumi,G.I., High,K.P. and Chilton,F.H. (2001) Early de novo gene expression is required for 15-deoxy-delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells. J. Biol. Chem., 276, 47131-47135.
21. Chawla,A., Barak,Y., Nagy,L., Liao,D., Tontonoz,P. and Evans,R.M. (2001) PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nature Med., 7, 48-52.
22. Castrillo,A., Diaz-Guerra,M.J., Hortelano,S., Martin-Sanz,P. and Bosca,L. (2000) Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-delta (12,14)-prostaglandin J (2) in activated murine macrophages. Mol. Cell. Biol., 20, 1692-1698.
23. Rossi,A., Kapahi,P., Natoli,G., Takahashi,T., Chen,Y., Karin,M. and Santoro,M.G. (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature, 403, 103-108.
24. Straus,D.S., Pascual,G., Li,M., Welch,J.S., Ricote,M., Hsiang,C.H., Sengchanthalangsy,L.L., Ghosh,G. and Glass,C.K. (2000) 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc. Natl Acad. Sci. USA, 97, 4844-4849.
25. Mullally,J.E., Moos,P.J., Edes,K. and Fitzpatrick,F.A. (2001) Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. J. Biol. Chem., 276, 30366-30373.
26. Hortelano,S., Castrillo,A., Alvarez,A.M. and Bosca,L. (2000) Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. J. Immunol., 165, 6525-6531.
27. Kondo,M., Oya-Ito,T., Kumagai,T., Osawa,T. and Uchida,K. (2001) Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J. Biol. Chem., 276, 12076-12083.
28. Li,L., Tao,J., Davaille,J., Feral,C., Mallat,A., Rieusset,J., Vidal,H. and Lotersztajn,S. (2001) 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J. Biol. Chem., 276, 38152-38158.
29. Lopez-Cabrera,M., Munoz,E., Blazquez,M.V., Ursa,M.A., Santis,A.G. and Sanchez-Madrid,F. (1995) Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. J. Biol. Chem., 270, 21545-21551.
30. Ruiz-Ruiz,C., Munoz-Pinedo,C. and Lopez-Rivas,A. (2000) Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program. Cancer Res., 60, 5673-5680.
31. Vayssiere,J.L., Petit,P.X., Risler,Y. and Mignotte,B. (1994) Commitment to apoptosis is associated with changes in mitochondrial bingenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc. Natl Acad. Sci. USA, 91, 11752-11756.
32. Mueller,E., Sarraf,P., Tontonoz,P., Evans,R.M., Martin,K.J., Zhang,M., Fletcher,C., Singer,S. and Spiegelman,B.M. (1998) Terminal differentiation of human breast cancer through PPAR gamma. Mol. Cell 1, 465-470.
33. Farrow,B. and Evers,B.M. (2003) Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. Biochem. Biophys. Res. Commun., 301, 50-53.
34. Altiok,S., Xu,M. and Spiegelman,B.M. (1997) PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev., 11, 1987-1998.
35. Morrison,R.F. and Farmer,S.R. (1999) Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18 (INK4c) and p21 (Waf1/Cip1), during adipogenesis. J. Biol. Chem. 274, 17088-17097.
36. Wang,P., Anderson,P.O., Chen,S., Paulsson,K.M., Sjogren,H.O. and Li,S. (2001) Inhibition of the transcription factors AP-1 and NF-kappaB in CD4 T cells by peroxisome proliferator-activated receptor gamma ligands. Int. Immunopharmacol., 1, 803-812.
37. Bureau,F., Desmet,C., Melotte,D., Jaspar,F., Volanti,C., Vanderplasschen,A., Pastoret,P.P., Piette,J. and Lekeux,P. (2002) A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition. J. Immunol., 168, 5318-5325.
38. Lennon,A.M., Ramauge,M., Dessouroux,A. and Pierre,M. (2002) MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-delta (12-14)-prostaglandin J (2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. J. Biol. Chem., 277, 29681-29685.
39. Huang,W.C., Chio,C.C., Chi,K.H., Wu,H.M. and Lin,W.W. (2002) Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta (12,14)-prostaglandin J (2), ciglitazone and GW1929. Exp. Cell Res. 277, 192-200.
40. Mates,J.M. and Sanchez-Jimenez,F.M. (2000) Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int. J. Biochem. Cell Biol., 32, 157-170.
41. Eng,C., Kiuru,M., Fernandez,M.J. and Aaltonen,L.A. (2003) A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat. Rev. Cancer, 3, 193-202.
42. Green,D.R. and Reed,J.C. (1998) Mitochondria and apoptosis. Science, 281, 1309-1312.
43. Wang,J., Silva,J.P., Gustafsson,C.M., Rustin,P. and Larsson,N.G. (2001) Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc. Natl Acad. Sci. USA, 98 4038-4043.
44. Djaldetti,M. (1982) Mitochondrial abnormalities in the cells of myeloma patients. Acta Haematol., 68, 241-248.
45. Ebneth,A., Godemann,R., Stamer,K., Illenberger,S., Trinczek,B. and Mandelkow,E. (1998) Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria and endoplasmic reticulum: implications for Alzheimer's disease. J. Cell Biol., 143, 777-794.
46. Nishino,I., Kobayashi,O., Goto,Y., Kurihara,M., Kumagai,K., Fujita,T., Hashimoto,K., Horai,S. and Nonaka,I. (1998) A new congenital muscular dystrophy with mitochondrial structural abnormalities. Muscle Nerve, 21, 40-47.
47. Dutcher,S.K. (2001) The tubulin fraternity: alpha to eta. Curr. Opin. Cell Biol., 13, 49-54.
48. Goncalves,A., Braguer,D., Kamath,K., Martello,L., Briand,C., Horwitz,S., Wilson,L. and Jordan,M.A. (2001) Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc. Natl Acad. Sci. USA, 98, 11737-11742.
49. Goncalves,A., Braguer,D., Carles,G., Andre,N., Prevot,C. and Briand,C. (2000) Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). Biochem. Pharmacol., 60, 1579-1584.
50. Pignatelli,M., Cocca,C., Santos,A. and Perez-Castillo,A. (2003) Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line. Oncogene, 22, 5446-5450.
51. Mullan,P.B., Quinn,J.E., Gilmore,P.M. et al. (2001) BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene, 20, 6123-6131.