Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 2, 2010, Pages 186-195

  Jansen, Thomas ^a   Hortmann, Marcus ^a   Oelze, Matthias ^a   Opitz, Benjamin ^a   Steven, Sebastian ^a   Schell, Richard ^a   Knorr, Maike ^a   Karbach, Susanne ^a   Schuhmacher, Swenja ^a   Wenzel, Philip ^a   Münzel, Thomas ^a   Daiber, Andreas ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Bilirubin; Biliverdin; Biliverdin reductase; Heme oxygenase 1; Hemin; Human umbilical vein endothelial cells; Hydrogen peroxide; Lipopolysaccharide; Peroxynitrite; Superoxide

Indexed keywords

BILIRUBIN; BILIVERDIN; BILIVERDIN REDUCTASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEME OXYGENASE 1; HEMIN; LIPOPOLYSACCHARIDE; OXIDOREDUCTASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME SYNTHESIS; GENE EXPRESSION; GENE SILENCING; HEART PROTECTION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANGIOTENSIN II; ANTIOXIDANTS; BILIRUBIN; BILIVERDINE; CYTOPROTECTION; ENDOTHELIAL CELLS; FREE RADICAL SCAVENGERS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HEME OXYGENASE-1; HUMANS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MITOCHONDRIA; MODELS, BIOLOGICAL; NEUTROPHILS; NITROSATION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST; TYROSINE; UMBILICAL VEINS; XANTHINE OXIDASE;

EID: 77953704443     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.04.011     Document Type: Article

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