15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ 2) induces cell death through caspase-independent mechanism in A172 human glioma cells

Neurochemical Research

Volumn 31, Issue 10, 2006, Pages 1247-1254

  Cho, W H ^a   Choi, C H ^a   Park, J Y ^a   Kang, S K ^a   Kim, Y K ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

15d PGJ2; Caspase independent apoptosis; Human A172 glioma cells; Mitochondrial depolarization; Reactive oxygen species

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ACETYLCYSTEINE; ANTIOXIDANT; APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN D2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; X LINKED INHIBITOR OF APOPTOSIS; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; DRUG DERIVATIVE;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; BRAIN TUMOR; DRUG ANTAGONISM; ENZYMOLOGY; GLIOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BRAIN NEOPLASMS; CASPASES; CELL DEATH; CELL LINE, TUMOR; GLIOMA; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN D2; REACTIVE OXYGEN SPECIES;

EID: 33750737034     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9157-0     Document Type: Article

References (52)

1. Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64(6):479-489
2. DeAngelis LM (2001) Brain tumors. N Engl J Med 344(2):114-123
3. Willson TM, Lambert MH, Kliewer SA (2001) Peroxisome proliferator- activated receptor gamma and metabolic disease. Annu Rev Biochem 70:341-367
4. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W (1992) Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68(5):879-887
5. Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347(6294):645-650
6. Guan Y, Breyer MD (2001) Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 60(1):14-30
7. Clay CE, Namen AM, Fonteh AN, Atsumi G, High KP, Chilton FH (2000) 15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. Prostaglandins Other Lipid Mediat 62(1):23-32
8. Nikitakis NG, Siavash H, Hebert C, Reynolds MA, Hamburger AW, Sauk JJ (2002) 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. Br J Cancer 87(12):1396-1403
9. Rosen ED, Spiegelman BM (2001) PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 276(41):37731-37734
10. Na HK, Surh YJ (2003) Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation. Biochem Pharmacol 66(8):1381-1391
11. Chen F, Wang M, O'Connor JP, He M, Tripathi T, Harrison LE (2003) Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. J Cell Biochem 90(4):732-744
12. Piva R, Gianferretti P, Ciucci A, Taulli R, Belardo G, Santoro MG (2005) 15-Deoxy-{Delta}12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-{kappa}B activity and downregulation of antiapoptotic proteins. Blood 105(4):1750-1758
13. Clay CE, Monjazeb A, Thorburn J, Chilton FH, High KP (2002) 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res 43(11):1818-1828
14. Grommes C, Landreth GE, Schlegel U, Heneka MT (2005) The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells. J Pharmacol Exp Ther 313(2):806-813
15. Yamakawa-Karakida N, Sugita K, Inukai T, Goi K, Nakamura M, Uno K, Sato H, Kagami K, Barker N, Nakazawa S (2002) Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity. Cell Death Differ 9(5):513-526
16. Zander T, Kraus JA, Grommes C, Schlegel U, Feinstein D, Klockgether T, Landreth G, Koenigsknecht J, Heneka MT (2002) Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. J Neurochem 81(5):1052-1060
17. Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C, Spiegelman BM (1998) Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 4(9):1046-1052
18. Strakova N, Ehrmann J, Bartos J, Malikova J, Dolezel J, Kolar Z (2005) Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors. Neoplasma 52(2):126-136
19. Akasaki Y, Liu G, Matundan HH, Ng H, Yuan X, Zeng Z, Black KL, Yu JS (2006) A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells. J Biol Chem 281(10):6165-6174
20. Houseknecht KL, Cole BM, Steele PJ (2002) Peroxisome proliferator- activated receptor gamma (PPARgamma) and its ligands: a review. Domest Anim Endocrinol 22(1):1-23
21. Fujiwara T, Horikoshi H (2000) Troglitazone and related compounds: therapeutic potential beyond diabetes. Life Sci 67(20):2405-2416
22. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83(5):803-812
23. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83(5):813-819
24. Bishop-Bailey D, Hla T (1999) Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. J Biol Chem 274(24):17042-17048
25. Kim EJ, Park KS, Chung SY, Sheen YY, Moon DC, Song YS, Kim KS, Song S, Yun YP, Lee MK, Oh KW, Yoon do Y, Hong JT (2003) Peroxisome proliferator- activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. J Pharmacol Exp Ther 307(2):505-517
26. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL (1998) The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 273(13):7770-7775
27. Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL (1993) Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem 268(19):13791-13798
28. Kroemer G, Dallaporta B, Resche-Rigon M (1998) The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60:619-642
29. Tatton WG, Olanow CW (1999) Apoptosis in neurodegenerative diseases: the role of mitochondria. Biochim Biophys Acta 1410(2):195-213
30. Castedo M, Ferri K, Roumier T, Metivier D, Zamzami N, Kroemer G (2002) Quantitation of mitochondrial alterations associated with apoptosis. J Immunol Methods 265(1-2):39-47
31. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16
32. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397(6718):441-446
33. Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1-15
34. Narayanan PK, Hart T, Elcock F, Zhang C, Hahn L, McFarland D, Schwartz L, Morgan DG, Bugelski P (2003) Troglitazone-induced intracellular oxidative stress in rat hepatoma cells: a flow cytometric assessment. Cytometry A 52(1):28-35
35. Perez-Ortiz JM, Tranque P, Vaquero CF, Domingo B, Molina F, Calvo S, Jordan J, Cena V, Llopis J (2004) Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J Biol Chem 279(10):8976-8985
36. Lennon AM, Ramauge M, Dessouroux A, Pierre M (2002) MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)- prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. J Biol Chem 277(33):29681-29685
37. Kondo M, Oya-Ito T, Kumagai T, Osawa T, Uchida K (2001) Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J Biol Chem 276(15):12076-12083
38. Li L, Tao J, Davaille J, Feral C, Mallat A, Rieusset J, Vidal H, Lotersztajn S (2001) 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J Biol Chem 276(41):38152-38158
39. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270(5240):1326-1331
40. Cobb MH (1999) MAP kinase pathways. Prog Biophys Mol Biol 71(3-4):479-500
41. Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103(2):239-252
42. Chana RS, Lewington AJ, Brunskill NJ (2004) Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. Kidney Int 65(6):2081-2090
43. Wilmer WA, Dixon C, Lu L, Hilbelink T, Rovin BH (2001) A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. Biochem Biophys Res Commun 281(1):57-62
44. Takeda K, Ichiki T, Tokunou T, Iino N, Takeshita A (2001) 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 276(52):48950-48955
45. Guo B, Koya D, Isono M, Sugimoto T, Kashiwagi A, Haneda M (2004) Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells. Diabetes 53(1):200-208
46. Straus DS, Glass CK (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21(3):185-210
47. Clay CE, Atsumi GI, High KP, Chilton FH (2001) Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells. J Biol Chem 276(50):47131-47135
48. Chen YC, Shen SC, Tsai SH (2005) Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. Biochim Biophys Acta 1743(3):291-304
49. Ray DM, Akbiyik F, Bernstein SH, Phipps RP (2005) CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism. J Immunol 174(7):4060-4069
50. Pignatelli M, Sanchez-Rodriguez J, Santos A, Perez-Castillo A (2005) 15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism. Carcinogenesis 26(1):81-92
51. Ni T, Li W, Zou F (2005) The ubiquitin ligase ability of IAPs regulates apoptosis. IUBMB Life 57(12):779-785
52. Liston P, Young SS, Mackenzie AE, Korneluk RG (1997) Life and death decisions: the role of the IAPs in modulating programmed cell death. Apoptosis 2(5):423-441