Accumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism

Cellular Signalling

Volumn 19, Issue 10, 2007, Pages 2098-2105

  Olmos, Gemma ^a   Conde, Isabel ^a   Arenas, Isabel ^a   Del Peso, Luis ^b   Castellanos, Carmen ^c   Landazuri, Manuel O ^c   Lucio Cazana, Javier ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

15 deoxy 12,14 prostaglandin J2; Electrophilic; Hypoxia inducible factor; Proximal tubular cells; Reactive oxygen species; Thiol groups

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 9,10 DIHYDRO 15D PROSTAGLANDIN J2; ACETYLCYSTEINE; ACROLEIN; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CIGLITAZONE; DITHIOTHREITOL; GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PROSTAGLANDIN A2; PROTEASOME; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHILIC STRESS; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; REDUCTION;

ANTIOXIDANTS; CELL LINE; CELL NUCLEUS; GLUTATHIONE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; KIDNEY TUBULES, PROXIMAL; PPAR GAMMA; PROSTAGLANDIN D2; PROTEASOME ENDOPEPTIDASE COMPLEX; REACTIVE OXYGEN SPECIES; REDUCING AGENTS; SULFHYDRYL COMPOUNDS; TRANSCRIPTION, GENETIC;

EID: 34548418008     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2007.06.004     Document Type: Article

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