15-Deoxy-Δ(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53

Journal of Biological Chemistry

Volumn 283, Issue 44, 2008, Pages 30273-30288

  Ho, Tsung Chuan ^a   Chen, Show Li ^b   Yang, Yuh Cheng ^a,c,d   Chen, Chia Yi ^a   Feng, Fang Ping ^a   Hsieh, Jui Wen ^a,c   Cheng, Huey Chuan ^a   Tsao, Yeou Ping ^a,e  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BLOOD VESSEL PROSTHESES; CELL DEATH; CHEMICAL REACTIONS; CYTOLOGY; NUCLEIC ACIDS; OXYGEN; PHOSPHORYLATION; RNA; SELF ASSEMBLY; SULFUR COMPOUNDS;

AMPHIPATHIC PEPTIDES; ANGIOGENESIS; ANGIOGENIC FACTORS; ANTI-OXIDANTS; APOPTOSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IN VITRO; IN-VIVO; INDUCED APOPTOSIS; MOUSE MODELS; NEOVASCULARIZATION; NUCLEAR FACTORS; P38 MAPK; P53 PROTEINS; PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS; PRETREATMENT; REACTIVE OXYGEN SPECIES; SEQUENTIAL ACTIVATIONS; VASCULAR ENDOTHELIAL CELLS;

ENDOTHELIAL CELLS;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIN DEPENDENT KINASE INHIBITOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PROSTAGLANDIN J2; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SERINE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NF-KAPPA B; PHOSPHORYLATION; PROSTAGLANDIN D2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 57649178299     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804196200     Document Type: Article

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