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Volumn 31, Issue 6, 2014, Pages

Histone deacetylase inhibitors in glioblastoma: Pre-clinical and clinical experience

Author keywords

Glioblastoma; Histone deacetylase inhibitors; Romidepsin; Valproic acid; Vorinostat

Indexed keywords

4 PHENYLBUTYRIC ACID; BEVACIZUMAB; CEDIRANIB; CILENGITIDE; COSITECAN; DACINOSTAT; DOXORUBICIN; ENTINOSTAT; ENZASTAURIN; ERLOTINIB; ETIRACETAM; ETOPOSIDE; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; ISOTRETINOIN; LOMUSTINE; PANOBINOSTAT; PROCARBAZINE; ROMIDEPSIN; TEMOZOLOMIDE; TRICHOSTATIN A; TUBACIN; VALPROIC ACID; VINCRISTINE; VORINOSTAT; DEPSIPEPTIDE; HISTONE DEACETYLASE; HYDROXAMIC ACID;

EID: 84901523040     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0985-5     Document Type: Review
Times cited : (86)

References (156)
  • 2
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27:4733-40.
    • (2009) J Clin Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 3
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of singleagent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Lyndon K, Moore K, et al. Phase II trial of singleagent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27:740-5.
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Lyndon, K.2    Moore, K.3
  • 4
    • 77954720781 scopus 로고    scopus 로고
    • Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    • Batchelor TT, Duda DG, di Tomaso E, et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010;28:2817-23.
    • (2010) J Clin Oncol , vol.28 , pp. 2817-2823
    • Batchelor, T.T.1    Duda, D.G.2    Di Tomaso, E.3
  • 5
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • Batchelor TT, Mulholland P, Neyns B, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol. 2013;31:3212-8.
    • (2013) J Clin Oncol , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3
  • 6
    • 63449086968 scopus 로고    scopus 로고
    • Epigenetic mechanisms in glioblastoma multiforme
    • Nagarajan RP, Costello JF. Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol. 2009;19:188-97.
    • (2009) Semin Cancer Biol , vol.19 , pp. 188-197
    • Nagarajan, R.P.1    Costello, J.F.2
  • 8
    • 34547890019 scopus 로고    scopus 로고
    • Functions of site-specific histone acetylation and deacetylation
    • Shahbazian MD, Grunstein M. Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem. 2007;76: 75-100.
    • (2007) Annu Rev Biochem , vol.76 , pp. 75-100
    • Shahbazian, M.D.1    Grunstein, M.2
  • 9
    • 69449102464 scopus 로고    scopus 로고
    • Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    • Wang Z, Zang C, Cui K, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell. 2009;138:1019-31.
    • (2009) Cell , vol.138 , pp. 1019-1031
    • Wang, Z.1    Zang, C.2    Cui, K.3
  • 10
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • DOI 10.1038/sj.onc.1210620, PII 1210620
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007;26: 5541-52. (Pubitemid 47255934)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 11
    • 1842578986 scopus 로고    scopus 로고
    • Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
    • DOI 10.1016/j.jmb.2004.02.006, PII S0022283604001408
    • Gregoretti IV, Lee YM, Goodson HV. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. 2004;338:17-31. (Pubitemid 38429783)
    • (2004) Journal of Molecular Biology , vol.338 , Issue.1 , pp. 17-31
    • Gregoretti, I.V.1    Lee, Y.-M.2    Goodson, H.V.3
  • 12
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C, Kumar C, Gnad F, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009;325:834-40.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3
  • 13
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • DOI 10.1158/1541-7786.MCR-07-0324
    • Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res. 2007;5: 981-9. (Pubitemid 350080267)
    • (2007) Molecular Cancer Research , vol.5 , Issue.10 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 15
    • 34547897023 scopus 로고    scopus 로고
    • Histone deacetylases and cancer
    • DOI 10.1038/sj.onc.1210610, PII 1210610
    • Glozak MA, Seto E. Histone deacetylases and cancer. Oncogene. 2007;26:5420-32. (Pubitemid 47255924)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5420-5432
    • Glozak, M.A.1    Seto, E.2
  • 17
    • 49349098483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy
    • Carew JS, Giles FJ, Nawrocki ST. Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy. Cancer Lett. 2008;269:7-17.
    • (2008) Cancer Lett , vol.269 , pp. 7-17
    • Carew, J.S.1    Giles, F.J.2    Nawrocki, S.T.3
  • 19
    • 4644364508 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
    • DOI 10.1158/0008-5472.CAN-04-0540
    • Qian DZ, Wang X, Kachhap SK, et al. The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 2004;64:6626-34. (Pubitemid 39297923)
    • (2004) Cancer Research , vol.64 , Issue.18 , pp. 6626-6634
    • Qian, D.Z.1    Wang, X.2    Kachhap, S.K.3    Kato, Y.4    Wei, Y.5    Zhang, L.6    Atadja, P.7    Pili, R.8
  • 20
    • 84860135029 scopus 로고    scopus 로고
    • Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death
    • Gammoh N, Lam D, Puente C, Ganley I, Marks PA, Jiang X. Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci USA. 2012;109:6561-5.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 6561-6565
    • Gammoh, N.1    Lam, D.2    Puente, C.3    Ganley, I.4    Marks, P.A.5    Jiang, X.6
  • 21
    • 58149390639 scopus 로고    scopus 로고
    • Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation
    • Watanabe M, Adachi S, Matsubara H, et al. Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation. Int J Cancer. 2009;124:55-67.
    • (2009) Int J Cancer , vol.124 , pp. 55-67
    • Watanabe, M.1    Adachi, S.2    Matsubara, H.3
  • 22
    • 77953170728 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage
    • Conti C, Leo E, Eichler GS, et al. Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage. Cancer Res. 2010; 70:4470-80.
    • (2010) Cancer Res , vol.70 , pp. 4470-4480
    • Conti, C.1    Leo, E.2    Eichler, G.S.3
  • 23
    • 78650575875 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
    • Namdar M, Perez G, Ngo L, Marks PA. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci USA. 2010;107:20003-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20003-20008
    • Namdar, M.1    Perez, G.2    Ngo, L.3    Marks, P.A.4
  • 24
    • 77957091318 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
    • Lee JH, Choy ML, Ngo L, Foster SS, Marks PA. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci USA. 2010;107:14639-44.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14639-14644
    • Lee, J.H.1    Choy, M.L.2    Ngo, L.3    Foster, S.S.4    Marks, P.A.5
  • 25
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol. 2009;27:5459-68.
    • (2009) J Clin Oncol , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 30
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2009;27:5410-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3
  • 31
    • 77954879663 scopus 로고    scopus 로고
    • Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
    • Whittaker SJ, Demierre M-F, Kim EJ, et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J Clin Oncol. 2010;28: 4485-91.
    • (2010) J Clin Oncol , vol.28 , pp. 4485-4491
    • Whittaker, S.J.1    Demierre, M.-F.2    Kim, E.J.3
  • 33
    • 33847372445 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: Effects on gene expression and growth of glioma cells in vitro and in vivo
    • DOI 10.1158/1078-0432.CCR-06-1261
    • Yin D, Ong JM, Hu J, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clin Cancer Res. 2007;13:1045-52. (Pubitemid 46340384)
    • (2007) Clinical Cancer Research , vol.13 , Issue.3 , pp. 1045-1052
    • Yin, D.1    Ong, J.M.2    Hu, J.3    Desmond, J.C.4    Kawamata, N.5    Konda, B.M.6    Black, K.L.7    Koeffler, H.P.8
  • 34
    • 82955237437 scopus 로고    scopus 로고
    • Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures
    • Xu J, Sampath D, Lang FF, et al. Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures. J Neurooncol. 2011;105:241-51.
    • (2011) J Neurooncol , vol.105 , pp. 241-251
    • Xu, J.1    Sampath, D.2    Lang, F.F.3
  • 35
    • 21044449385 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    • Eyüpoglu IY, Hahnen E, Buslei R, et al. Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo. J Neurochem. 2005;93:992-9.
    • (2005) J Neurochem , vol.93 , pp. 992-999
    • Eyüpoglu, I.Y.1    Hahnen, E.2    Buslei, R.3
  • 36
    • 34250761428 scopus 로고    scopus 로고
    • Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model
    • DOI 10.1007/s11060-007-9337-z
    • Ugur HC, Ramakrishna N, Bello L, et al. Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model. J Neurooncol. 2007;83:267-75. (Pubitemid 46952237)
    • (2007) Journal of Neuro-Oncology , vol.83 , Issue.3 , pp. 267-275
    • Ugur, H.C.1    Ramakrishna, N.2    Bello, L.3    Menon, L.G.4    Kim, S.-K.5    Black, P.M.6    Carroll, R.S.7
  • 37
    • 79959416877 scopus 로고    scopus 로고
    • Enhancer of zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells
    • Orzan F, Pellegatta S, Poliani PL, et al. Enhancer of zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. Neuropathol Appl Neurobiol. 2011;37:381-94.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 381-394
    • Orzan, F.1    Pellegatta, S.2    Poliani, P.L.3
  • 38
    • 79952105934 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2: A potential target for tumor therapy
    • Xiao Y. Enhancer of zeste homolog 2: a potential target for tumor therapy. Int J Biochem Cell Biol. 2011;43:474-7.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 474-477
    • Xiao, Y.1
  • 39
    • 57649124289 scopus 로고    scopus 로고
    • Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    • Cao Q, Yu J, Dhanasekaran SM, et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene. 2008;27:7274-84.
    • (2008) Oncogene , vol.27 , pp. 7274-7284
    • Cao, Q.1    Yu, J.2    Dhanasekaran, S.M.3
  • 40
    • 77951931604 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture
    • An Z, Gluck CB, Choy ML, Kaufman LI. Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture. Cancer Lett. 2010;292:215-27.
    • (2010) Cancer Lett , vol.292 , pp. 215-227
    • An, Z.1    Gluck, C.B.2    Choy, M.L.3    Kaufman, L.I.4
  • 41
    • 44449135127 scopus 로고    scopus 로고
    • HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin
    • Svechnikova I, Almqvist PM, Ekström TJ. HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. Int J Oncol. 2008;32:821-7. (Pubitemid 351780592)
    • (2008) International Journal of Oncology , vol.32 , Issue.4 , pp. 821-827
    • Svechnikova, I.1    Almqvist, P.M.2    Ekstrom, T.J.3
  • 42
    • 0025190642 scopus 로고
    • CNS stem cells express a new class of intermediate filament protein
    • Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell. 1990;60:585-95.
    • (1990) Cell , vol.60 , pp. 585-595
    • Lendahl, U.1    Zimmerman, L.B.2    McKay, R.D.3
  • 43
    • 70449604638 scopus 로고    scopus 로고
    • The 10q 25.3-26.1G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas
    • Boulay J-L, Ionescu M-CS, Sivasankaran B, et al. The 10q 25.3-26.1G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Int J Oncol. 2009;35:1123-31.
    • (2009) Int J Oncol , vol.35 , pp. 1123-1131
    • Boulay, J.-L.1    Ionescu, M.-C.S.2    Sivasankaran, B.3
  • 44
    • 0036935895 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide induces astrocyte differentiation of precursor cells from developing cerebral cortex
    • DOI 10.1006/mcne.2002.1189
    • Vallejo I, Vallejo M. Pituitary adenylate cyclase-activating polypeptide induces astrocyte differentiation of precursor cells from developing cerebral cortex. Mol Cell Neurosci. 2002;21:671-83. (Pubitemid 36062723)
    • (2002) Molecular and Cellular Neuroscience , vol.21 , Issue.4 , pp. 671-683
    • Vallejo, I.1    Vallejo, M.2
  • 45
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signalling in development and disease
    • Clevers H. Wnt/beta-catenin signalling in development and disease. Cell. 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 46
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • DOI 10.1038/nrc2389, PII NRC2389
    • Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387-98. (Pubitemid 351589714)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 47
    • 79952823258 scopus 로고    scopus 로고
    • Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme
    • Foltz G, Yoon JG, Lee H, et al. Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme. Genes Cancer. 2010;1:81-90.
    • (2010) Genes Cancer , vol.1 , pp. 81-90
    • Foltz, G.1    Yoon, J.G.2    Lee, H.3
  • 48
    • 33745634864 scopus 로고    scopus 로고
    • Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer
    • DOI 10.1093/carcin/bgi379
    • Ai L, Tao Q, Zhong S, et al. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis. 2006;27:1341-8. (Pubitemid 43985409)
    • (2006) Carcinogenesis , vol.27 , Issue.7 , pp. 1341-1348
    • Ai, L.1    Tao, Q.2    Zhong, S.3    Fields, C.R.4    Kim, W.-J.5    Lee, M.W.6    Cui, Y.7    Brown, K.D.8    Robertson, K.D.9
  • 51
    • 18344377028 scopus 로고    scopus 로고
    • Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
    • DOI 10.1038/sj.onc.1208511
    • He B, Reguart N, You L, et al. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene. 2005;24:3054-8. (Pubitemid 40675537)
    • (2005) Oncogene , vol.24 , Issue.18 , pp. 3054-3058
    • He, B.1    Reguart, N.2    You, L.3    Mazieres, J.4    Xu, Z.5    Lee, A.Y.6    Mikami, I.7    McCormick, F.8    Jablons, D.M.9
  • 52
    • 0344431240 scopus 로고    scopus 로고
    • FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
    • DOI 10.1006/excr.1998.4027
    • Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res. 1998;241:126-33. (Pubitemid 28366586)
    • (1998) Experimental Cell Research , vol.241 , Issue.1 , pp. 126-133
    • Nakajima, H.1    Kim, Y.B.2    Terano, H.3    Yoshida, M.4    Horinouchi, S.5
  • 53
    • 0033822112 scopus 로고    scopus 로고
    • P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
    • Sandor V, Senderowicz A, Mertins S, et al. P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer. 2000;83:817-25.
    • (2000) Br J Cancer , vol.83 , pp. 817-825
    • Sandor, V.1    Senderowicz, A.2    Mertins, S.3
  • 57
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • DOI 10.1038/sj.leu.2403910, PII 2403910
    • Bradbury CA, Khanim FL, Hayden R, et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that change selectively in response to deacetylase inhibitors. Leukemia. 2005;19:1751-9. (Pubitemid 41486152)
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6    Craddock, C.7    Turner, B.M.8
  • 58
    • 0842325787 scopus 로고    scopus 로고
    • Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
    • DOI 10.1158/0008-5472.CAN-03-0799
    • Gurvich N, Tsygankova OM, Meinkoth JL, Klein PS. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res. 2004;64:1079-86. (Pubitemid 38176913)
    • (2004) Cancer Research , vol.64 , Issue.3 , pp. 1079-1086
    • Gurvich, N.1    Tsygankova, O.M.2    Meinkoth, J.L.3    Klein, P.S.4
  • 59
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Göttlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001;20:6969-78.
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Göttlicher, M.1    Minucci, S.2    Zhu, P.3
  • 61
    • 33645071947 scopus 로고    scopus 로고
    • Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
    • Chavez-Blanco A, Perez-Plasencia C, Perez-Cardenas E, et al. Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines. Cancer Cell Int. 2006;6:2.
    • (2006) Cancer Cell Int , vol.6 , pp. 2
    • Chavez-Blanco, A.1    Perez-Plasencia, C.2    Perez-Cardenas, E.3
  • 64
    • 77950543254 scopus 로고    scopus 로고
    • Epigenetic modifiers as anticancer drugs: Effectiveness of valproic acid in neural crest-derived tumor cells
    • Papi A, Ferreri AM, Rocchi P, Guerra F, Orlandi M. Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. Anticancer Res. 2010;30: 535-40.
    • (2010) Anticancer Res , vol.30 , pp. 535-540
    • Papi, A.1    Ferreri, A.M.2    Rocchi, P.3    Guerra, F.4    Orlandi, M.5
  • 65
    • 3042859183 scopus 로고    scopus 로고
    • The activity of antiepileptic drugs as histone deacetylase inhibitors
    • DOI 10.1111/j.0013-9580.2004.00104.x
    • Eyal S, Yagen B, Sobol E, Altschuler Y, Shmuel M, Bialer M. The activity of antiepileptic drugs as histone deacetylase inhibitors. Epilepsia. 2004;45:737-44. (Pubitemid 38890970)
    • (2004) Epilepsia , vol.45 , Issue.7 , pp. 737-744
    • Eyal, S.1    Yagen, B.2    Sobol, E.3    Altschuler, Y.4    Shmuel, M.5    Bialer, M.6
  • 66
    • 78650101872 scopus 로고    scopus 로고
    • Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide
    • Bobustuc GC, Baker CH, Limaye A, et al. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol. 2010;12:917-27.
    • (2010) Neuro Oncol , vol.12 , pp. 917-927
    • Bobustuc, G.C.1    Baker, C.H.2    Limaye, A.3
  • 67
    • 33745073751 scopus 로고    scopus 로고
    • Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    • Eyüpoglu IY, Hahnen E, Tränkle C, et al. Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275. Mol Cancer Ther. 2006;5:1248-55.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1248-1255
    • Eyüpoglu, I.Y.1    Hahnen, E.2    Tränkle, C.3
  • 69
    • 68049121594 scopus 로고    scopus 로고
    • DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation
    • Sun P, Xia S, Lal B, et al. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009;27:1473-86.
    • (2009) Stem Cells , vol.27 , pp. 1473-1486
    • Sun, P.1    Xia, S.2    Lal, B.3
  • 70
    • 1942485780 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells
    • DOI 10.1016/j.ejca.2003.11.034, PII S0959804904001005
    • Asklund T, Appelskog IB, Ammerpohl O, Ekström TJ, Almqvist PM. Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells. Eur J Cancer. 2004;40:1073-81. (Pubitemid 38496266)
    • (2004) European Journal of Cancer , vol.40 , Issue.7 , pp. 1073-1081
    • Asklund, T.1    Appelskog, I.B.2    Ammerpohl, O.3    Ekstrom, T.J.4    Almqvist, P.M.5
  • 72
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • DOI 10.1038/nrd2133, PII NRD2133
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006;5: 769-84. (Pubitemid 44348499)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 77
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 80
    • 84861666362 scopus 로고    scopus 로고
    • Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition
    • Clark PA, Iida M, Treisman DM, et al. Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia. 2012;14:420-8.
    • (2012) Neoplasia , vol.14 , pp. 420-428
    • Clark, P.A.1    Iida, M.2    Treisman, D.M.3
  • 81
    • 0043016178 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    • Nimmanapalli R, Fuino L, Bali P, et al. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res. 2003;63:5126-35. (Pubitemid 37022654)
    • (2003) Cancer Research , vol.63 , Issue.16 , pp. 5126-5135
    • Nimmanapalli, R.1    Fuino, L.2    Bali, P.3    Gasparetto, M.4    Glozak, M.5    Tao, J.6    Moscinski, L.7    Smith, C.8    Wu, J.9    Jove, R.10    Atadja, P.11    Bhalla, K.12
  • 82
    • 26944440597 scopus 로고    scopus 로고
    • Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells
    • DOI 10.1038/sj.leu.2403868, PII 2403868
    • Yu C, Dasmahapatra G, Dent P, Grant S. Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells. Leukemia. 2005;19:1579-89. (Pubitemid 43090402)
    • (2005) Leukemia , vol.19 , Issue.9 , pp. 1579-1589
    • Yu, C.1    Dasmahapatra, G.2    Dent, P.3    Grant, S.4
  • 83
    • 33947242973 scopus 로고    scopus 로고
    • Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation
    • DOI 10.1158/1078-0432.CCR-06-1751
    • Yu C, Friday BB, Lai JP, et al. Abrogation of MAPK and Akt signalling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation. Clin Cancer Res. 2007;13:1140-8. (Pubitemid 46424053)
    • (2007) Clinical Cancer Research , vol.13 , Issue.4 , pp. 1140-1148
    • Yu, C.1    Friday, B.B.2    Lai, J.-P.3    McCollum, A.4    Atadja, P.5    Roberts, L.R.6    Adjei, A.A.7
  • 85
    • 70349329440 scopus 로고    scopus 로고
    • Abrogation of mitogen-activated protein kinase and Akt signalling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells
    • Jane EP, Premkumar DR, Addo-Yobo SO, Pollack IF. Abrogation of mitogen-activated protein kinase and Akt signalling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. J Pharmacol Exp Ther. 2009;331:327-37.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 327-337
    • Jane, E.P.1    Premkumar, D.R.2    Addo-Yobo, S.O.3    Pollack, I.F.4
  • 86
    • 79960557142 scopus 로고    scopus 로고
    • Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models
    • Marino AM, Sofiadis A, Baryawno N, et al. Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models. Biochem Biophys Res Commun. 2011;411:208-12.
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 208-212
    • Marino, A.M.1    Sofiadis, A.2    Baryawno, N.3
  • 87
    • 84905585531 scopus 로고    scopus 로고
    • Addition of erlotinib changes gene expression in glioblastoma cell lines treated with vorinostat
    • Bezecny P, Wong F, Sang NJPX, Pieri C, Mulholland PJ, Sheer D. Addition of erlotinib changes gene expression in glioblastoma cell lines treated with vorinostat. Eur J Cancer. 2011; 47(Suppl 1):S578.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL. 1
    • Bezecny, P.1    Wong, F.2    Sang, N.J.P.X.3    Pieri, C.4    Mulholland, P.J.5    Sheer, D.6
  • 88
    • 77951708371 scopus 로고    scopus 로고
    • CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor, and human epidermal growth factor receptor 2, exerts potent anticancer activity
    • Lai CJ, Bao R, Tao X, et al. CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor, and human epidermal growth factor receptor 2, exerts potent anticancer activity. Cancer Res. 2010;70:3647-56.
    • (2010) Cancer Res , vol.70 , pp. 3647-3656
    • Lai, C.J.1    Bao, R.2    Tao, X.3
  • 89
    • 13244262655 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
    • DOI 10.1038/sj.onc.1208225
    • Yin D, Zhou H, Kumagai T, et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene. 2005;24:344-54. (Pubitemid 40188583)
    • (2005) Oncogene , vol.24 , Issue.3 , pp. 344-354
    • Yin, D.1    Zhou, H.2    Kumagai, T.3    Liu, G.4    Ong, J.M.5    Black, K.L.6    Koeffler, H.P.7
  • 90
    • 4444250842 scopus 로고    scopus 로고
    • Effects of the proteasome inhibitor ritonavir on glioma growth in vitro and in vivo
    • Laurent N, de Boüard S, Guillamo JS, et al. Effects of the proteasome inhibitor ritonavir on glioma growth in vitro and in vivo. Mol Cancer Ther. 2004;3:129-36.
    • (2004) Mol Cancer Ther , vol.3 , pp. 129-136
    • Laurent, N.1    De Boüard, S.2    Guillamo, J.S.3
  • 91
    • 52949083797 scopus 로고    scopus 로고
    • Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells
    • Yu C, Friday BB, Yang L, et al. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol. 2008;10:309-19.
    • (2008) Neuro Oncol , vol.10 , pp. 309-319
    • Yu, C.1    Friday, B.B.2    Yang, L.3
  • 92
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • DOI 10.1016/j.cell.2004.12.012, PII S0092867404011997
    • Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004;119: 941-53. (Pubitemid 40037608)
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6    Casero, R.A.7    Shi, Y.8
  • 93
    • 80052743686 scopus 로고    scopus 로고
    • Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors
    • Singh MM, Manton CA, Bhat KP, et al. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011;13:894-903.
    • (2011) Neuro Oncol , vol.13 , pp. 894-903
    • Singh, M.M.1    Manton, C.A.2    Bhat, K.P.3
  • 96
    • 49649114803 scopus 로고    scopus 로고
    • Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death
    • Egler V, Korur S, Failly M, et al. Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. Clin Cancer Res. 2008;14:3132-40.
    • (2008) Clin Cancer Res , vol.14 , pp. 3132-3140
    • Egler, V.1    Korur, S.2    Failly, M.3
  • 97
    • 77956059770 scopus 로고    scopus 로고
    • Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines
    • Sarcar B, Kahali S, Chinnaiyan P. Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines. J Neurooncol. 2010;99:201-7.
    • (2010) J Neurooncol , vol.99 , pp. 201-207
    • Sarcar, B.1    Kahali, S.2    Chinnaiyan, P.3
  • 98
    • 23044487814 scopus 로고    scopus 로고
    • It's about time: Scheduling alters effect of histone deacetylase inhibitors on camptothecin-treated cells
    • DOI 10.1158/0008-5472.CAN-05-0836
    • Bevins RL, Zimmer SG. It's about time: scheduling alters effect of histone deacetylase inhibitors on camptothecin-treated cells. Cancer Res. 2005;65:6957-66. (Pubitemid 41060736)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6957-6966
    • Bevins, R.L.1    Zimmer, S.G.2
  • 99
    • 65249131145 scopus 로고    scopus 로고
    • Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: Translational and phase I/II clinical trial
    • Daud AI, Dawson J, DeConti RC, et al. Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial. Clin Cancer Res. 2009;15:2479-87.
    • (2009) Clin Cancer Res , vol.15 , pp. 2479-2487
    • Daud, A.I.1    Dawson, J.2    DeConti, R.C.3
  • 100
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • DOI 10.1038/nrc1977, PII NRC1977
    • Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006;6:789-802. (Pubitemid 44450467)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.10 , pp. 789-802
    • Pommier, Y.1
  • 101
    • 0242610850 scopus 로고    scopus 로고
    • Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA
    • Kim MS, Blake M, Baek JH, Kohlhagen G, Pommier Y, Carrier F. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 2003;63:7291-300. (Pubitemid 37413470)
    • (2003) Cancer Research , vol.63 , Issue.21 , pp. 7291-7300
    • Kim, M.S.1    Blake, M.2    Baek, J.H.3    Kohlhagen, G.4    Pommier, Y.5    Carrier, F.6
  • 102
    • 35448999681 scopus 로고    scopus 로고
    • Valproic acid induces p21 and topoisomerase-II (a/b) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
    • DOI 10.1007/s11060-007-9402-7
    • Das CM, Aguilera D, Vasquez H, et al. Valproic acid induces p21 and topoisomerase-II (a /b) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. J Neurooncol. 2007;85:159-70. (Pubitemid 47629397)
    • (2007) Journal of Neuro-Oncology , vol.85 , Issue.2 , pp. 159-170
    • Das, C.M.1    Aguilera, D.2    Vasquez, H.3    Prasad, P.4    Zhang, M.5    Wolff, J.E.6    Gopalakrishnan, V.7
  • 103
    • 38149069545 scopus 로고    scopus 로고
    • Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines
    • Ciusani E, Balzarotti M, Calatozzolo C, et al. Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. Oncol Res. 2007;16:453-63.
    • (2007) Oncol Res , vol.16 , pp. 453-463
    • Ciusani, E.1    Balzarotti, M.2    Calatozzolo, C.3
  • 104
    • 16544379283 scopus 로고    scopus 로고
    • Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid
    • Marchion DC, Bicaku E, Daud AI, Richon V, Sullivan DM, Munster PN. Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid. J Cell Biochem. 2004;92:223-37.
    • (2004) J Cell Biochem , vol.92 , pp. 223-237
    • Marchion, D.C.1    Bicaku, E.2    Daud, A.I.3    Richon, V.4    Sullivan, D.M.5    Munster, P.N.6
  • 105
    • 28544432910 scopus 로고    scopus 로고
    • Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta
    • DOI 10.1158/1078-0432.CCR-05-1073
    • Marchion DC, Bicaku E, Turner JG, Daud AI, Sullivan DM, Munster PN. Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. Clin Cancer Res. 2005;11:8467-75. (Pubitemid 41746962)
    • (2005) Clinical Cancer Research , vol.11 , Issue.23 , pp. 8467-8475
    • Marchion, D.C.1    Bicaku, E.2    Turner, J.G.3    Daud, A.I.4    Sullivan, D.M.5    Munster, P.N.6
  • 106
    • 79958254773 scopus 로고    scopus 로고
    • Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275
    • Bangert A, Häcker S, Cristofanon S, Debatin KM, Fulda S. Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275. Anticancer Drug. 2011;22:494-9.
    • (2011) Anticancer Drug , vol.22 , pp. 494-499
    • Bangert, A.1    Häcker, S.2    Cristofanon, S.3    Debatin, K.M.4    Fulda, S.5
  • 107
    • 23044440043 scopus 로고    scopus 로고
    • Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)- ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6] -tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines
    • DOI 10.1124/jpet.105.083956
    • Xiao JJ, Huang Y, Dai Z, et al. Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8, 20,23-tetraazabicyclo[8,7,6]-tricos- 16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. J Pharmacol Exp Ther. 2005;314:467-75. (Pubitemid 41058285)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.314 , Issue.1 , pp. 467-475
    • Xiao, J.J.1    Huang, Y.2    Dai, Z.3    Sadee, W.4    Chen, J.5    Liu, S.6    Marcucci, G.7    Byrd, J.8    Covey, J.M.9    Wright, J.10    Grever, M.11    Chan, K.K.12
  • 108
    • 32644438678 scopus 로고    scopus 로고
    • Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells
    • DOI 10.1182/blood-2004-10-4126
    • Tabe Y, Konopleva M, Contractor R, et al. Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood. 2006;107:1546-54. (Pubitemid 43242393)
    • (2006) Blood , vol.107 , Issue.4 , pp. 1546-1554
    • Tabe, Y.1    Konopleva, M.2    Contractor, R.3    Munsell, M.4    Schober, W.D.5    Jin, L.6    Tsutsumi-Ishii, Y.7    Nagaoka, I.8    Igari, J.9    Andreeff, M.10
  • 109
    • 40049111860 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor apicidin-mediated drug resistance: Involvement of Pglycoprotein
    • Kim YK, Kim NH, Hwang JW, et al. Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of Pglycoprotein. Biochem Biophys Res Commun. 2008;368:959-64.
    • (2008) Biochem Biophys Res Commun , vol.368 , pp. 959-964
    • Kim, Y.K.1    Kim, N.H.2    Hwang, J.W.3
  • 110
    • 66349104315 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induction of P-glycoprotein transcription requires both histone deacetylase 1 dissociation and recruitment of CAAT/enhancer binding protein beta and pCAF to the promoter region
    • Kim SN, Kim NH, Lee W, Seo DW, Kim YK. Histone deacetylase inhibitor induction of P-glycoprotein transcription requires both histone deacetylase 1 dissociation and recruitment of CAAT/enhancer binding protein beta and pCAF to the promoter region. Mol Cancer Res. 2009;7:735-44.
    • (2009) Mol Cancer Res , vol.7 , pp. 735-744
    • Kim, S.N.1    Kim, N.H.2    Lee, W.3    Seo, D.W.4    Kim, Y.K.5
  • 111
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci
    • DOI 10.1158/1535-7163.MCT-06-0022
    • Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006;5:1967-74. (Pubitemid 44336568)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.8 , pp. 1967-1974
    • Munshi, A.1    Tanaka, T.2    Hobbs, M.L.3    Tucker, S.L.4    Richon, V.M.5    Meyn, R.E.6
  • 112
    • 34748877735 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation: A strategy for tumor radiosensitization
    • DOI 10.1200/JCO.2007.11.6202
    • Camphausen K, Tofilon PJ. Inhibition of histone deacetylation: a strategy for tumor radiosensitization. J Clin Oncol. 2007;25: 4051-6. (Pubitemid 47492949)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.26 , pp. 4051-4056
    • Camphausen, K.1    Tofilon, P.J.2
  • 115
    • 34548564426 scopus 로고    scopus 로고
    • Attenuated DNA damage repair by trichostatin a through BRCA1 suppression
    • DOI 10.1667/RR0811.1
    • Zhang Y, Carr T, Dimtchev A, Zaer N, Dritschilo A, Jung M. Attenuated DNA damage repair by trichostatin a through BRCA1 suppression. Radiat Res. 2007;168:115-24. (Pubitemid 351292932)
    • (2007) Radiation Research , vol.168 , Issue.1 , pp. 115-124
    • Zhang, Y.1    Carr, T.2    Dimtchev, A.3    Zaer, N.4    Dritschilo, A.5    Jung, M.6
  • 117
    • 53049089057 scopus 로고    scopus 로고
    • Postradiation sensitization of the histone deacetylase inhibitor valproic acid
    • Chinnaiyan P, Cerna D, Burgan WE, et al. Postradiation sensitization of the histone deacetylase inhibitor valproic acid. Clin Cancer Res. 2008;14:5410-5.
    • (2008) Clin Cancer Res , vol.14 , pp. 5410-5415
    • Chinnaiyan, P.1    Cerna, D.2    Burgan, W.E.3
  • 119
    • 3042568739 scopus 로고    scopus 로고
    • Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor
    • DOI 10.1016/j.ijrobp.2004.03.001, PII S0360301604003827
    • Kim JH, Shin JH, Kim IH. Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. Int J Radiat Oncol Biol Phys. 2004;59:1174-80. (Pubitemid 38834312)
    • (2004) International Journal of Radiation Oncology Biology Physics , vol.59 , Issue.4 , pp. 1174-1180
    • Kim, J.H.1    Shin, J.H.2    Kim, I.H.3
  • 121
    • 69249209745 scopus 로고    scopus 로고
    • Vorinostat in solid and hematologic malignancies
    • Siegel D, Hussein M, Belani C, et al. Vorinostat in solid and hematologic malignancies. J Hematol Oncol. 2009;2:31.
    • (2009) J Hematol Oncol , vol.2 , pp. 31
    • Siegel, D.1    Hussein, M.2    Belani, C.3
  • 125
    • 38149140216 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer
    • Blumenschein GR Jr, Kies MS, Papadimitrakopoulou VA, et al. Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer. Invest New Drugs. 2008;26:81-7.
    • (2008) Invest New Drugs , vol.26 , pp. 81-87
    • Blumenschein Jr., G.R.1    Kies, M.S.2    Papadimitrakopoulou, V.A.3
  • 127
    • 58149242889 scopus 로고    scopus 로고
    • A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: A California cancer consortium study
    • Luu TH, Morgan RJ, Leong L, et al. A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California cancer consortium study. Clin Cancer Res. 2008;14:7138-42.
    • (2008) Clin Cancer Res , vol.14 , pp. 7138-7142
    • Luu, T.H.1    Morgan, R.J.2    Leong, L.3
  • 128
    • 67649399669 scopus 로고    scopus 로고
    • Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: A Wisconsin oncology network phase II study
    • Traynor AM, Dubey S, Eickhoff JC, et al. Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin oncology network phase II study. J Thorac Oncol. 2009;4:522-6.
    • (2009) J Thorac Oncol , vol.4 , pp. 522-526
    • Traynor, A.M.1    Dubey, S.2    Eickhoff, J.C.3
  • 129
    • 50249095068 scopus 로고    scopus 로고
    • Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal or non-small cell lung cancer
    • Vansteenkiste J, Van Cutsem E, Dumez H, et al. Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal or non-small cell lung cancer. Invest New Drugs. 2008;26: 483-8.
    • (2008) Invest New Drugs , vol.26 , pp. 483-488
    • Vansteenkiste, J.1    Van Cutsem, E.2    Dumez, H.3
  • 130
    • 43049091153 scopus 로고    scopus 로고
    • A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
    • Gynecologic Oncology Group
    • Modesitt SC, Sill M, Hoffman JS, Bender DP, Gynecologic Oncology Group. A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. Gynecol Oncol. 2008;109:182-6.
    • (2008) Gynecol Oncol , vol.109 , pp. 182-186
    • Modesitt, S.C.1    Sill, M.2    Hoffman, J.S.3    Bender, D.P.4
  • 131
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: A north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ, et al. Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol. 2009;27:2052-8.
    • (2009) J Clin Oncol , vol.27 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3
  • 132
    • 80053579502 scopus 로고    scopus 로고
    • Phase I study of vorinostat in combination with temozolomide in patients with malignant gliomas
    • abstr 2032
    • Wen PY, Puduvalli VK, Kuhn JG, et al. Phase I study of vorinostat in combination with temozolomide in patients with malignant gliomas. 2011; J Clin Oncol 29(suppl): abstr 2032.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Wen, P.Y.1    Puduvalli, V.K.2    Kuhn, J.G.3
  • 133
    • 84891500057 scopus 로고    scopus 로고
    • Apediatric phase I trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: A children's oncology group phase I consortium study
    • abstr 9579
    • Hummel TR,Wagner LM, Ahern CH, et al. Apediatric phase I trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a children's oncology group phase I consortium study. 2011; J Clin Oncol 29(suppl): abstr 9579.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Hummel, T.R.1    Wagner, L.M.2    Ahern, C.H.3
  • 134
    • 84856238982 scopus 로고    scopus 로고
    • Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma
    • Chinnaiyan P, Chowdhary S, Potthast L, et al. Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro Oncol. 2012;14:93-100.
    • (2012) Neuro Oncol , vol.14 , pp. 93-100
    • Chinnaiyan, P.1    Chowdhary, S.2    Potthast, L.3
  • 135
    • 84905579157 scopus 로고    scopus 로고
    • Phase I study of vorinostat combined with isotretinoin and carboplatin in adults with recurrent malignant gliomas
    • Puduvalli VK, Penas-Prado M, Gilbert MR, et al. Phase I study of vorinostat combined with isotretinoin and carboplatin in adults with recurrent malignant gliomas. Neuro Oncol. 2010;12(suppl 4):iv69-78.
    • (2010) Neuro Oncol , vol.12 , Issue.SUPPL. 4
    • Puduvalli, V.K.1    Penas-Prado, M.2    Gilbert, M.R.3
  • 136
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study
    • Friday BB, Anderson SK, Buckner J, et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro Oncol. 2012;14:215-21.
    • (2012) Neuro Oncol , vol.14 , pp. 215-221
    • Friday, B.B.1    Anderson, S.K.2    Buckner, J.3
  • 137
    • 84905588306 scopus 로고    scopus 로고
    • A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A children's oncology group study
    • abstr 9522
    • Muscal JA, Thompson PA, Horton TM, et al. A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a children's oncology group study. J Clin Oncol 29(suppl): abstr 9522, 2011.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Muscal, J.A.1    Thompson, P.A.2    Horton, T.M.3
  • 138
    • 79959956310 scopus 로고    scopus 로고
    • A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American brain tumor consortium study 03-03
    • Iwamoto FM, Lamborn KR, Kuhn JG, et al. A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American brain tumor consortium study 03-03. Neuro Oncol. 2011;13:509-16.
    • (2011) Neuro Oncol , vol.13 , pp. 509-516
    • Iwamoto, F.M.1    Lamborn, K.R.2    Kuhn, J.G.3
  • 140
    • 80054705372 scopus 로고    scopus 로고
    • Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma
    • Weller M, Gorlia T, Cairncross JG, et al. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology. 2011;77:1156-64.
    • (2011) Neurology , vol.77 , pp. 1156-1164
    • Weller, M.1    Gorlia, T.2    Cairncross, J.G.3
  • 141
    • 0035107070 scopus 로고    scopus 로고
    • Nitroso-urea-cisplatin-based chemotherapy associated with valproate: Increase of haematologic toxicity
    • DOI 10.1023/A:1008331708395
    • Bourg V, Lebrun C, Chichmanian RM, Thomas P, Frenay M. Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. Ann Oncol. 2001;12:217-9. (Pubitemid 32223871)
    • (2001) Annals of Oncology , vol.12 , Issue.2 , pp. 217-219
    • Bourg, V.1    Lebrun, C.2    Chichmanian, R.M.3    Thomas, P.4    Frenay, M.5
  • 142
    • 20944451523 scopus 로고    scopus 로고
    • P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy
    • DOI 10.1007/s11060-004-2338-2
    • Oberndorfer S, Piribauer M, Marosi C, Lahrmann H, Hitzenberger P, Grisold W. P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy. J Neurooncol. 2005;72:255-60. (Pubitemid 40867409)
    • (2005) Journal of Neuro-Oncology , vol.72 , Issue.3 , pp. 255-260
    • Oberndorfer, S.1    Piribauer, M.2    Marosi, C.3    Lahrmann, H.4    Hitzenberger, P.5    Grisold, W.6
  • 143
    • 79551691082 scopus 로고    scopus 로고
    • Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: A children's oncology group report
    • Su JM, Li X-N, Thompson P, et al. Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report. Clin Cancer Res. 2011;17:589-97.
    • (2011) Clin Cancer Res , vol.17 , pp. 589-597
    • Su, J.M.1    Li, X.-N.2    Thompson, P.3
  • 144
    • 56249124221 scopus 로고    scopus 로고
    • Valproic acid was well tolerated in heavily pretreated pediatric patients with highgrade glioma
    • Wolff JEA, Kramm C, Kortmann R-D, et al. Valproic acid was well tolerated in heavily pretreated pediatric patients with highgrade glioma. J Neurooncol. 2008;90:309-14.
    • (2008) J Neurooncol , vol.90 , pp. 309-314
    • Wolff, J.E.A.1    Kramm, C.2    Kortmann, R.-D.3
  • 145
    • 48849103965 scopus 로고    scopus 로고
    • Influence of valproic acid on outcome of high-grade gliomas in children
    • Masoudi A, Elopre M, Amini E, et al. Influence of valproic acid on outcome of high-grade gliomas in children. Anticancer Res. 2008;28:2437-42.
    • (2008) Anticancer Res , vol.28 , pp. 2437-2442
    • Masoudi, A.1    Elopre, M.2    Amini, E.3
  • 146
    • 73649123907 scopus 로고    scopus 로고
    • An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell. 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 149
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycineaspartic acid peptide, in recurrent glioblastoma multiforme
    • Reardon DA, Fink KL, Mikkelsen T, et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycineaspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol. 2008;26:5610-7.
    • (2008) J Clin Oncol , vol.26 , pp. 5610-5617
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3
  • 150
    • 68949085460 scopus 로고    scopus 로고
    • Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma
    • Clarke JL, Iwamoto FM, Sul J, et al. Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma. J Clin Oncol. 2009;27:3861-7.
    • (2009) J Clin Oncol , vol.27 , pp. 3861-3867
    • Clarke, J.L.1    Iwamoto, F.M.2    Sul, J.3
  • 151
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • Wick W, Puduvalli VK, Chamberlain MC, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol. 2010;28: 1168-74.
    • (2010) J Clin Oncol , vol.28 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3
  • 152
    • 78049515473 scopus 로고    scopus 로고
    • Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma
    • Brada M, Stenning S, Gabe R, et al. Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. J Clin Oncol. 2010;28:4601-8.
    • (2010) J Clin Oncol , vol.28 , pp. 4601-4608
    • Brada, M.1    Stenning, S.2    Gabe, R.3
  • 153
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
    • Wick W, Platten M, Meisner C, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012;13:707-15.
    • (2012) Lancet Oncol , vol.13 , pp. 707-715
    • Wick, W.1    Platten, M.2    Meisner, C.3
  • 154
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
    • Malmström A, Grønberg BH, Marosi C, et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol. 2012;13:916-26.
    • (2012) Lancet Oncol , vol.13 , pp. 916-926
    • Malmström, A.1    Grønberg, B.H.2    Marosi, C.3
  • 155
    • 84891785971 scopus 로고    scopus 로고
    • Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
    • Gilbert MR, Wang M, Aldape KD, et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol. 2013;31:4085-91.
    • (2013) J Clin Oncol , vol.31 , pp. 4085-4091
    • Gilbert, M.R.1    Wang, M.2    Aldape, K.D.3
  • 156
    • 84905576854 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov/.


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