P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy

Journal of Neuro-Oncology

Volumn 72, Issue 3, 2005, Pages 255-260

  Oberndorfer, Stefan ^a   Piribauer, Maria ^a   Marosi, Christine ^b   Lahrmann, Heinz ^a   Hitzenberger, Peter ^a   Grisold, Wolfgang ^a  

^a KAISER FRANZ JOSEF HOSPITAL   (Austria)

^b University Clinic   (Austria)

Author keywords

Antiepileptic drugs; CCNU; Cytochrome P450; Glioblastoma; Haematotoxicity

Indexed keywords

ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; CARBAMAZEPINE; CYTOCHROME P450; DACARBAZINE; ETIRACETAM; FOTEMUSTINE; LAMOTRIGINE; LOMUSTINE; PHENYTOIN; PROCARBAZINE; TEMOZOLOMIDE; VALPROIC ACID; VINCRISTINE;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG METABOLISM; GLIOBLASTOMA; HUMAN; MAJOR CLINICAL STUDY; RETROSPECTIVE STUDY; SEIZURE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; ANTINEOPLASTIC AGENTS; BLOOD CELL COUNT; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; GLIOBLASTOMA; HUMANS; LOMUSTINE; MALE; MIDDLE AGED; NEUROSURGICAL PROCEDURES; RETROSPECTIVE STUDIES; SEIZURES; SURVIVAL; SURVIVAL ANALYSIS;

EID: 20944451523     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-004-2338-2     Document Type: Article

References (45)

1. AA Brandes F Vistola U Basso F Berti G Pinna A Rotilio M Gardiman R Scienza S Monfardini M. Ermani 2003 A prospective study on glioblastoma in the elderly Cancer 1 657-662 10.1002/cncr.11097
2. EL Chang W Yi PK Allen VA Levin RE Sawaya MH. Maor 2003 Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: Outcome and prognostic factors Int J Radiat Oncol Biol Phys 56 519-528 10.1016/S0360-3016(02)04522-4 12738329
3. X Durando JJ Lemaire J Tortochaux I Van-Praagh F Kwiatkowski C Vincent C Bailly P Vergelle B Irthum J Chazal JO. Bay 2003 High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: A retrospective analysis of 114 patients Bone Marrow Transplant 3 559-564 10.1038/sj.bmt.1703889
4. SA Grossman A O'Neil M Grunnet M Mehta JL Pearlman H Wagner M Gilbert HB Newton R. Hellman 2003 Eastern Cooperative Oncology Group. Phase III study comparing three cycles of infusional carmustine and cisplatin followed by radiation therapy with radiation therapy and concurrent carmustine in patients with newly diagnosed supratentorial glioblastoma multiforme: Eastern Cooperative Oncology Group Trial 2394. J Clin Oncol 15 1485-1491 10.1200/JCO.2003.10.035
5. IV Pech K Peterson JG. Cairncross 1998 Chemotherapy for brain tumors Oncology. 12 537-543 1:STN:280:DyaK1c3js1Cnsg%3D%3D 9575527
6. S Trippoli F Pelagotti A Messori F Vacca M Vaiani S. Maltoni 2003 Survival of patients with recurrent malignant glioma treated with temozolomide: A retrospective observational study Drugs R D 4 285-291 1:CAS:528:DC%2BD3sXosFChtro%3D 12952497
7. R Stupp PY Dietrich S Kraljevic A Pica I Maillard P Maeder R Meuli R Panzer G Pizzolato R Miralbell F Porchet L Regli N Tribolet de RO Mirimanoff S. Leyvraz 2002 Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide J Clin Oncol 1 1375-1382 10.1200/JCO.20.5.1375
8. M Westphal DC Hilt E Bortey P Delavault R Olivares PC Warnke IR Whittle J Jaaskelainen Z. Ram 2003 A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma Neuro-oncol 5 79-88 1:CAS:528:DC%2BD3sXjtVKltL4%3D 12672279
9. PL Moots RJ Maciunas DR Eisert RA Parker K Laporte B. Abou-Khalil 1995 The course of seizure disorders in patients with malignant gliomas Arch Neuro 52 717-724 1:STN:280:ByqA2cvjsVQ%3D 7619029
10. Greenberg HS, Chandler WF, Sandler HM. (1999). Brain Tumors. Contemporary Neurology Series. Oxford University Press. 299-317.
11. K Lote AE Stenwig K Skullerud H. Hirschberg 1998 Prevalence and prognostic significance of epilepsy in patients with gliomas Eur J Cancer 34 98-102 10.1016/S0959-8049(97)00374-2 1:STN:280:DyaK1c3oslejuw%3D%3D 9624245
12. S Oberndorfer T Schmal H Lahrmann S Urbanits K Lindner W. Grisold 2002 The frequency of seizures in patients with primary brain tumors or cerebral metastasis Wien Klin Wochenschr 30 911-916
13. PN Patsalos E. Perucca 2003 Clinically important drug interactions in epilepsy: General features and interactions between antiepileptic drugs Lancet Neurol 2 347-356 10.1016/S1474-4422(03)00409-5 1:CAS:528:DC%2BD3sXms1yrtbw%3D 12849151
14. PN Patsalos E. Perucca 2003 Clinically important drug interactions in epilepsy: Interactions between antiepileptic drugs and other drugs Lancet Neurol 2 473-481 10.1016/S1474-4422(03)00483-6 1:CAS:528:DC%2BD3sXmslamtbs%3D 12878435
15. KT Kivisto HK Kroemer M. Eichelbaum 1995 The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: Implications for drug interactions Br J Clin Pharmacol 40 523-530 1:STN:280:BymB2cjgt1E%3D 8703657
16. CJ Vecht GL Wagner EB. Wilms 2003 Interactions between antiepileptic and chemotherapeutic drugs Lancet Neurol 2 404-409 10.1016/ S1474-4422(03)00435-6 1:CAS:528:DC%2BD3sXms1yhsLk%3D 12849118
17. MG Neuman NH Shear PM Jacobson-Brown GG Katz HK Neilson IM Malkiewicz RG Cameron F. Abbott 2001 CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity Clin Biochem 34 211-218 10.1016/ S0009-9120(01)00217-X 1:CAS:528:DC%2BD3MXltl2hu74%3D 11408019
18. PN Patsalos W Froscher F Pisani CM. Rijn van 2002 The importance of drug interactions in epilepsy therapy Epilepsia 43 365-385 10.1046/ j.1528-1157.2002.13001.x 1:CAS:528:DC%2BD38XjtlSlur8%3D 11952767
19. V Bourg C Lebrun RM Chichmanian P Thomas M. Frenay 2001 Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity Ann Oncol 12 217-219 10.1023/ A:1008331708395 1:STN:280:DC%2BD3M3gvFantA%3D%3D 11300327
20. VA Levin J Stearns A Byrd A Finn RJ. Weinkam 1979 The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU J Pharmacol Exp Ther 208 1-6 1:CAS:528:DyaE1MXhtlarsbk%3D 759602
21. PJ Muller CH Tator ML. Bloom 1983 Use of phenobarbital and high doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the treatment of brain tumor-bearing mice Cancer Res 43 2068-2071 1:CAS:528:DyaL3sXktVShsbs%3D 6831437
22. World Health Organization: International Histological Classification of Toumors. Histological Typing of Tumours of the Central Nervous Sysrem. Geneva, WHO, No 2, 1979
23. JC Buckner JM Reid K Wright SH Kaufmann C Erlichman M Ames S Cha JR O'Fallon LJ Schaaf LL. Miller 2003 Irinotecan in the treatment of glioma patients: Current and future studies on the north central cancer treatment group Cancer 97 2352-2358 10.1002/cncr.11304 1:CAS:528:DC%2BD3sXjvVSgsrg%3D 12712456
24. TF Cloughesy E Filka J Kuhn G Nelson F Kabbinavar H Friedman LL Miller GL. Elfring 2003 Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen Cancer 97 2381-2386 10.1002/cncr.11306 1:CAS:528:DC%2BD3sXjvVSgs74%3D 12712460
25. MR Fetell SA Grossman JD Fisher B Erlanger E Rowinsky J Stockel S. Piantadosi 1997 Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions New Approaches to Brain Tumor Therapy Central Nervous System Consortium. J Clin Oncol 15 3121-3128 1:CAS:528:DyaK2sXmt1Sqtrs%3D 9294475
26. HS Friedman WP Petros AH Friedman LJ Schaaf T Kerby J Lawyer M Parry PJ Houghton S Lovell K Rasheed T Cloughsey ES Stewart OM Colvin JM Provenzale RE McLendon DD Bigner I Cokgor M Haglund J Rich D Ashley J Malczyn GL Elfring LL. Miller 1999 Irinotecan therapy in adults with recurrent or progressive malignant glioma J Clin Oncol 17 1516-1525 1:CAS:528:DyaK1MXjsF2ms7o%3D 10334539
27. SA Grossman F Hochberg J Fisher TL Chen L Kim R Gregory LB Grochow S. Piantadosi 1998 Increased 9-aminocamptothecin dose requirements in patients on anticonvulsants NABTT CNS Consortium. The new approaches to brain tumor therapy. Cancer Chemother Pharmacol 42 118-126 10.1007/ s002800050794 1:CAS:528:DyaK1cXjslWmur0%3D 9654111
28. RA. Kramer 1999 Cytochrome P450-inducing antiepileptics increase the clearence of vincristine in patients with brain tumors Clin Pharmocol Ther 66 589-593
29. JG. Kuhn 2002 Influence of anticonvulsants on the metabolism and elimination of irinotecan A North American Brain Tumor Consortium preliminary report. Oncology 16 33-40
30. E Raymond M Fabbro V Boige O Rixe M Frenay G Vassal S Faivre E Sicari C Germa JM Rodier L Vernillet JP. Armand 2003 Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naive patients with glioblastoma Ann Oncol 14 603-614 1:STN:280:DC%2BD3s7jsVSisw%3D%3D 12649109
31. Hildebrand J, Michael Brada (eds). Epileptic seizures. In: Differential Diagnosis in Neuro-oncology. Oxford University Press, 2001, pp 47-58
32. MJ. Van den Bent 2003 The role of chemotherapy in brain metastases Eur J Cancer 39 2114-2120 1:CAS:528:DC%2BD3sXns1KlsLs%3D 14522368
33. DF Smith JL Hutton D Sandemann PM Foy MD Shaw IR Williams DW. Chadwick 1991 The prognosis of primary intracerebral tumours presenting with epilepsy: The outcome of medical and surgical management J Neurol Neurosurg Psychiatry 54 915-920 1:STN:280:By2D2sfpsVQ%3D 1744647
34. K Villikka KT Kivisto H Maenpaa H Joensuu PJ. Neuvonen 1999 Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors Clin Pharmacol Ther 66 589-593
35. AE Ahmed M Grissom R El-Azhary A Haque PJ Boor J. Costanzi 1987 Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital Cancer Chemother Pharmacol 19 103-108 1:CAS:528:DyaL1cXjtFCrtQ%3D%3D 3105904
36. PJ McKee J Blacklaw E Butler RA Gillham MJ. Brodie 1992 Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients Epilepsy Res 11 193-198 1:STN:280:ByyD3M%2FptFE%3D 1396534
37. E. Perucca 2001 Clinical pharmacology and therapeutic use of the new antiepileptic drugs Fundam Clin Pharmacol 15 405-417 1:CAS:528:DC%2BD38Xht1Kqt7w%3D 11860529
38. E Perucca S Hebdige GM Frigo G Gatti S Lecchini A. Crema 1980 Interaction between phenytoin and valproic acid: Plasma protein binding and metabolic effects Clin Pharmacol Ther 28 779-789 1:CAS:528:DyaL3MXns1Gjuw%3D%3D 6777108
39. E Perucca O Dulac S Shorvon T. Tomson 2001 Harnessing the clinical potential of antiepileptic drug therapy: Dosage optimisation CNS Drugs 15 609-621 1:CAS:528:DC%2BD3MXntlant70%3D 11524033
40. EE Samara RG Granneman GF Witt JH. Cavanaugh 1997 Effect of valproate on the pharmacokinetics and pharmacodynamics of lorazepam J Clin Pharmacol 37 442-450 1:CAS:528:DyaK2sXjs1Cnsbs%3D 9156377
41. TK Chang H Chen DJ. Waxman 1994 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosurea (CCNU modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 C11 messenger RNA levels Drug Metab Dispos 22 673-679 1:CAS:528:DyaK2cXmsVGntr0%3D 7835216
42. CL. Litterst 1981 Prolonged depression of hepatic microsomal drug metabolism and hemoprotein levels following a single dose of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Biochem Pharmacol 30 1014-1016 1:CAS:528:DyaL3MXkvFSqsbo%3D 7236311
43. S Tong Y Hirokata CL Litterst TE. Gram 1984 Interaction of the oncolytic drug, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea with the mixed-function oxidase system in rats Chem Biol Interact 49 105-119 1:CAS:528:DyaL2cXktlaqsL0%3D 6722931
44. C Liddle BJ Goodwin J George M Tapner GC. Farrell 1998 Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes J Clin Endocrinol Meta 83 2411-2416 1:CAS:528:DyaK1cXksVSisr8%3D
45. TE. Lackner 1991 Interaction of dexamethasone with phenytoin Pharmacotherapy 11 344-347 1:STN:280:By2D38%2FjsVw%3D 1923918