The 10q25.3-26.1 G protein-coupled receptor geneGPR26 is epigenetically silenced in human gliomas

International Journal of Oncology

Volumn 35, Issue 5, 2009, Pages 1123-1131

  Boulay, Jean Louis ^a   Ionescu, Mihai Constantin S ^a   Sivasankaran, Balasubramanian ^a   Labuhn, Martin ^a   Dolder Schlienger, Béatrice ^a   Taylor, Elisabeth ^a   Morin Jr , Pier ^b   Hemmings, Brian A ^b   Lino, Maria Maddalena ^a   Jones, Graham ^a   Maier, Daniel ^a   Merlo, Adrian ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

10q25.3 26.1; Cyclic AMP; Epigenetic silencing; G protein coupled receptor; Malignant glioma

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; COMPLEMENTARY DNA; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 26; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; EPIGENETICS; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE MAPPING; GENE OVEREXPRESSION; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, NORTHERN; BRAIN NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 10; FLOW CYTOMETRY; GENE SILENCING; GLIOMA; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70449604638     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000428     Document Type: Article

References (39)

1. Knobbe CB, Merlo A and Reifenberger G: Pten signaling in gliomas. Neurooncology 4: 196-211, 2002.
2. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH and Parsons R: Pten, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947, 1997.
3. Maier D, Zhang Z, Taylor E, Hamou MF, Gratzl O, van Meir EG, Scott RJ and Merlo A: Somatic deletion mapping on chromosome 10 and sequence analysis of pten/mmac1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Oncogene 16: 3331-3335, 1998. (Pubitemid 28330433)
4. Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, Hess KR, Myers JN, Hong YK, Yung WK and Steck PA: Differential expression of mmac/pten in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res 59: 1820-1824, 1999.
5. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH and Tavtigian SV: Identification of a candidate tumour suppressor gene, mmac1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362, 1997. (Pubitemid 27147102)
6. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R and Yamada KM: Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor pten. Science 280: 1614-1617, 1998. (Pubitemid 28277707)
7. Albarosa R, Colombo BM, Roz L, Magnani I, Pollo B, Cirenei N, Giani C, Conti AM, DiDonato S and Finocchiaro G: Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cm interval on chromosome 10q. Am J Hum Genet 58: 1260-1267, 1996. (Pubitemid 26153838)
8. Fults D and Pedone C: Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme. Genes Chromosomes Cancer 7: 173-177, 1993. (Pubitemid 23194428)
9. Maier D, Comparone D, Taylor E, Zhang Z, Gratzl O, van Meir EG, Scott RJ and Merlo A: New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26. Oncogene 15: 997-1000, 1997. (Pubitemid 27399561)
10. Moschonas NK, Spurr NK and Mao J: Report of the first international workshop on human chromosome 10 mapping 1995. Cytogenet Cell Genet 72: 100-112, 1996.
11. Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD and Bigner SH: Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene 10: 2243-2246, 1995.
12. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A and Poustka A: Dmbt1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 17: 32-39, 1997. (Pubitemid 27377529)
13. Wu W, Kemp BL, Proctor ML, Gazdar AF, Minna JD, Hong WK and Mao L: Expression of dmbt1, a candidate tumor suppressor gene, is frequently lost in lung cancer. Cancer Res 59: 1846-1851, 1999.
14. Sasaki H, Betensky RA, Cairncross JG and Louis DN: Dmbt1 polymorphisms: relationship to malignant glioma tumorigenesis. Cancer Res 62: 1790-1796, 2002. (Pubitemid 34408504)
15. 6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci USA 71: 639-643, 1974.
16. Inoue R, Isono M, Abe M, Abe T and Kobayashi H: A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. Neurol Res 25: 875-879, 2003.
17. Costello JF, Futscher BW, Tano K, Graunke DM and Pieper RO: Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with mgmt expression in human glioma cells. J Biol Chem 269: 17228-17237, 1994. (Pubitemid 24204047)
18. Hegi ME, Diserens AC, Gorlia T, Hamou MF, De Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC and Stupp R: Mgmt gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352: 997-1003, 2005. (Pubitemid 40349502)
19. 6-methylguanine DNA methyltransferase (MGMT) CPG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 17: 5612-5619, 1997.
20. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF and Marchese A: Cloning and characterization of additional members of the g protein-coupled receptor family. Biochim Biophys Acta 1490: 311-323, 2000. (Pubitemid 30103804)
21. Ohgaki H and Kleihues P: Genetic pathways to primary and secondary glioblastoma. Am J Pathol 170: 1445-1453, 2007. (Pubitemid 47339290)
22. Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC and Van Meir EG: Frequent co-alterations of tp53, p16/cdkn2a, p14arf, pten tumor suppressor genes in human glioma cell lines. Brain Pathol 9: 469-479, 1999. (Pubitemid 29316287)
23. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CPG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996. (Pubitemid 26296693)
24. Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA and Clark SJ: Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 38: 540-549, 2006.
25. Bresnick JN, Skynner HA, Chapman KL, Jack AD, Zamiara E, Negulescu P, Beaumont K, Patel S and McAllister G: Identification of signal transduction pathways used by orphan g protein-coupled receptors. Assay Drug Dev Technol 1: 239-249, 2003.
26. Vallejo I and Vallejo M: Pituitary adenylate cyclase-activating polypeptide induces astrocyte differentiation of precursor cells from developing cerebral cortex. Mol Cell Neurosci 21: 671-683, 2002. (Pubitemid 36062723)
27. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE and Baylin SB: E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55: 5195-5199, 1995.
28. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D and Baylin SB: Inactivation of the cdkn2/p16/mts1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530, 1995.
29. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA and Baylin SB: Incidence and functional consequences of hmlh1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95: 6870-6875, 1998. (Pubitemid 28278073)
30. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB and Sidransky D: 5' CPG island methylation is associated with transcriptional silencing of the tumour suppressor p16/cdkn2/mts1 in human cancers. Nat Med 1: 686-692, 1995.
31. Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC and Herman JG: Socs-1, a negative regulator of the jak/stat pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28: 29-35, 2001. (Pubitemid 32405812)
32. Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428, 2002.
33. Yoshida M, Furumai R, Nishiyama M, Komatsu Y, Nishino N and Horinouchi S: Histone deacetylase as a new target for cancer chemotherapy. Cancer Chemother Pharmacol 48 (Suppl. 1): S20-S26, 2001. (Pubitemid 33738367)
34. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN and Bird A: Transcriptional repression by the methyl-CPG-binding protein MECP2 involves a histone deacetylase complex. Nature 393: 386-389, 1998. (Pubitemid 28269714)
35. Cameron EE, Bachman KE, Myohanen S, Herman JG and Baylin SB: Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21: 103-107, 1999. (Pubitemid 29036293)
36. Carter AN, Cole CL, Playle AG, Ramsay EJ and Shervington AA: Gpr26: A marker for primary glioblastoma? Mol Cell Probes 22: 133-137, 2008.
37. Park PS, Filipek S, Wells JW and Palczewski K: Oligomerization of g protein-coupled receptors: past, present, and future. Biochemistry 43: 15643-15656, 2004. (Pubitemid 39665065)
38. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G and Guest PC: Oligomerization of g-protein-coupled receptors shown by selective co-immunoprecipitation. J Biol Chem 277: 15482-15485, 2002. (Pubitemid 34967814)
39. Prasad KN, Cole WC, Yan XD, Nahreini P, Kumar B, Hanson A and Prasad JE: Defects in camp-pathway may initiate carcinogenesis in dividing nerve cells: A review. Apoptosis 8: 579-586, 2003. (Pubitemid 37411742)