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Volumn 43, Issue 4, 2011, Pages 474-477

Enhancer of zeste homolog 2: A potential target for tumor therapy

Author keywords

Cancer therapy; Enhancer of zeste homolog 2; H3K27; Methylation; Phosphorylation

Indexed keywords

TRANSCRIPTION FACTOR EZH2;

EID: 79952105934     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.01.005     Document Type: Short Survey
Times cited : (35)

References (29)
  • 1
    • 39449104311 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 regulates actin polymerization in human prostate cancer cells
    • DOI 10.1002/pros.20705
    • R.J. Bryant, S.J. Winder, S.S. Cross, F.C. Hamdy, and V.T. Cunliffe The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells Prostate 68 3 2008 255 263 (Pubitemid 351273054)
    • (2008) Prostate , vol.68 , Issue.3 , pp. 255-263
    • Bryant, R.J.1    Winder, S.J.2    Cross, S.S.3    Hamdy, F.C.4    Cunliffe, V.T.5
  • 2
    • 67650511419 scopus 로고    scopus 로고
    • Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2
    • S. Burdach, S. Plehm, R. Unland, U. Dirksen, A. Borkhardt, and M.S. Staege Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2 Cell Cycle 8 13 2009 1991 1996
    • (2009) Cell Cycle , vol.8 , Issue.13 , pp. 1991-1996
    • Burdach, S.1    Plehm, S.2    Unland, R.3    Dirksen, U.4    Borkhardt, A.5    Staege, M.S.6
  • 3
    • 57649124289 scopus 로고    scopus 로고
    • Repression of E-cadherin by the Polycomb group protein EZH2 in cancer
    • Q. Cao, J. Yu, S.M. Dhanasekaran, J.H. Kim, R.S. Mani, and S.A. Tomlins Repression of E-cadherin by the Polycomb group protein EZH2 in cancer Oncogene 27 58 2008 7274 7284
    • (2008) Oncogene , vol.27 , Issue.58 , pp. 7274-7284
    • Cao, Q.1    Yu, J.2    Dhanasekaran, S.M.3    Kim, J.H.4    Mani, R.S.5    Tomlins, S.A.6
  • 4
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in polycomb-group silencing
    • DOI 10.1126/science.1076997
    • R. Cao, L. Wang, H. Wang, L. Xia, H. Erdjument-Bromage, and P. Tempst Role of histone H3 lysine 27 methylation in Polycomb-group silencing Science 298 5595 2002 1039 1043 (Pubitemid 35247314)
    • (2002) Science , vol.298 , Issue.5595 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6    Jones, R.S.7    Zhang, Y.8
  • 5
    • 0034070298 scopus 로고    scopus 로고
    • The human EZH2 gene: Genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders
    • DOI 10.1038/sj.ejhg.5200439
    • C. Cardoso, C. Mignon, G. Hetet, B. Grandchamps, M. Fontes, and L. Colleaux The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders Eur J Hum Genet 8 3 2000 174 180 (Pubitemid 30189860)
    • (2000) European Journal of Human Genetics , vol.8 , Issue.3 , pp. 174-180
    • Cardoso, C.1    Mignon, C.2    Hetet, G.3    Grandchamps, B.4    Fontes, M.5    Colleaux, L.6
  • 6
    • 0031922879 scopus 로고    scopus 로고
    • Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein
    • DOI 10.1093/hmg/7.4.679
    • C. Cardoso, S. Timsit, L. Villard, M. Khrestchatisky, M. Fontes, and L. Colleaux Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein Hum Mol Genet 7 4 1998 679 684 (Pubitemid 28152267)
    • (1998) Human Molecular Genetics , vol.7 , Issue.4 , pp. 679-684
    • Cardoso, C.1    Timsit, S.2    Villard, L.3    Khrestchatisky, M.4    Fontes, M.5    Colleaux, L.6
  • 7
    • 26844520965 scopus 로고    scopus 로고
    • Molecular biology: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    • DOI 10.1126/science.1118947
    • T.L. Cha, B.P. Zhou, W. Xia, Y. Wu, C.C. Yang, and C.T. Chen Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 Science 310 5746 2005 306 310 (Pubitemid 41457195)
    • (2005) Science , vol.310 , Issue.5746 , pp. 306-310
    • Cha, T.-L.1    Zhou, B.P.2    Xia, W.3    Wu, Y.4    Yang, C.-C.5    Chen, C.-T.6    Ping, B.7    Otte, A.P.8    Hung, M.-C.9
  • 8
    • 0030588658 scopus 로고    scopus 로고
    • Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2
    • DOI 10.1006/geno.1996.0588
    • H. Chen, C. Rossier, and S.E. Antonarakis Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2 Genomics 38 1 1996 30 37 (Pubitemid 26423910)
    • (1996) Genomics , vol.38 , Issue.1 , pp. 30-37
    • Chen, H.1    Rossier, C.2    Antonarakis, S.E.3
  • 9
    • 34547487035 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin
    • DOI 10.1002/hep.21668
    • Y. Chen, M.C. Lin, H. Yao, H. Wang, A.Q. Zhang, and J. Yu Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin Hepatology 46 1 2007 200 208 (Pubitemid 47171937)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 200-208
    • Chen, Y.1    Lin, M.C.2    Yao, H.3    Wang, H.4    Zhang, A.-Q.5    Yu, J.6    Hui, C.-K.7    Lau, G.K.8    He, M.-L.9    Sung, J.10    Kung, H.-F.11
  • 10
    • 78149285100 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
    • S. Chen, L.R. Bohrer, A.N. Rai, Y. Pan, L. Gan, and X. Zhou Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 Nat Cell Biol 12 11 2010 1108 1114
    • (2010) Nat Cell Biol , vol.12 , Issue.11 , pp. 1108-1114
    • Chen, S.1    Bohrer, L.R.2    Rai, A.N.3    Pan, Y.4    Gan, L.5    Zhou, X.6
  • 11
    • 34548392803 scopus 로고    scopus 로고
    • Epigenetic control of hematopoietic stem cell aging: The case of Ezh2
    • DOI 10.1196/annals.1392.008, Hematopoietic Stem Cells VI
    • G. De Haan, and A. Gerrits Epigenetic control of hematopoietic stem cell aging the case of EZH2 Ann N Y Acad Sci 1106 2007 233 239 (Pubitemid 47443044)
    • (2007) Annals of the New York Academy of Sciences , vol.1106 , pp. 233-239
    • De Haan, G.1    Gerrits, A.2
  • 13
    • 35148822835 scopus 로고    scopus 로고
    • Structural Basis of EZH2 Recognition by EED
    • DOI 10.1016/j.str.2007.08.007, PII S0969212607003140
    • Z. Han, X. Xing, M. Hu, Y. Zhang, P. Liu, and J. Chai Structural basis of EZH2 recognition by EED Structure 15 10 2007 1306 1315 (Pubitemid 47539160)
    • (2007) Structure , vol.15 , Issue.10 , pp. 1306-1315
    • Han, Z.1    Xing, X.2    Hu, M.3    Zhang, Y.4    Liu, P.5    Chai, J.6
  • 15
    • 39049185212 scopus 로고    scopus 로고
    • Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma
    • Y. Komohara, M. Harada, Y. Arima, S. Suekane, M. Noguchi, and A. Yamada Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma Int J Oncol 29 6 2006 1555 1560
    • (2006) Int J Oncol , vol.29 , Issue.6 , pp. 1555-1560
    • Komohara, Y.1    Harada, M.2    Arima, Y.3    Suekane, S.4    Noguchi, M.5    Yamada, A.6
  • 16
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle CDKs and cancer: A changing paradigm
    • M. Malumbres, and M. Barbacid Cell cycle CDKs and cancer: a changing paradigm Nat Rev Cancer 9 3 2009 153 166
    • (2009) Nat Rev Cancer , vol.9 , Issue.3 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 17
    • 55949132133 scopus 로고    scopus 로고
    • EZH1 and EZH2 maintain repressive chromatin through different mechanisms
    • R. Margueron, G. Li, K. Sarma, A. Blais, J. Zavadil, and C.L. Woodcock EZH1 and EZH2 maintain repressive chromatin through different mechanisms Mol Cell 32 4 2008 503 518
    • (2008) Mol Cell , vol.32 , Issue.4 , pp. 503-518
    • Margueron, R.1    Li, G.2    Sarma, K.3    Blais, A.4    Zavadil, J.5    Woodcock, C.L.6
  • 19
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • R.D. Morin, N.A. Johnson, T.M. Severson, A.J. Mungall, J. An, and R. Goya Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Nat Genet 42 2 2010 181 185
    • (2010) Nat Genet , vol.42 , Issue.2 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 21
    • 29344445843 scopus 로고    scopus 로고
    • Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder
    • DOI 10.1158/1078-0432.CCR-05-1047
    • J.D. Raman, N.P. Mongan, S.K. Tickoo, S.A. Boorjian, D.S. Scherr, and L.J. Gudas Increased expression of the Polycomb group gene, EZH2, in transitional cell carcinoma of the bladder Clin Cancer Res 11 24 Pt 1 2005 8570 8576 (Pubitemid 43005902)
    • (2005) Clinical Cancer Research , vol.11 , Issue.24 , pp. 8570-8576
    • Raman, J.D.1    Mongan, N.P.2    Tickoo, S.K.3    Boorjian, S.A.4    Scherr, D.S.5    Gudas, L.J.6
  • 22
    • 0037846472 scopus 로고    scopus 로고
    • Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer
    • D.R. Rhodes, M.G. Sanda, A.P. Otte, A.M. Chinnaiyan, and M.A. Rubin Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer J Natl Cancer Inst 95 9 2003 661 668 (Pubitemid 36603722)
    • (2003) Journal of the National Cancer Institute , vol.95 , Issue.9 , pp. 661-668
    • Rhodes, D.R.1    Sanda, M.G.2    Otte, A.P.3    Chinnaiyan, A.M.4    Rubin, M.A.5
  • 23
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of Polycomb gene silencing: Knowns and unknowns
    • J.A. Simon, and R.E. Kingston Mechanisms of Polycomb gene silencing: knowns and unknowns Nat Rev Mol Cell Biol 10 10 2009 697 708
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 24
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • DOI 10.1038/nrc1991, PII NRC1991
    • A. Sparmann, and M. van Lohuizen Polycomb silencers control cell fate, development and cancer Nat Rev Cancer 6 11 2006 846 856 (Pubitemid 44629896)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 27
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • S. Varambally, Q. Cao, R.S. Mani, S. Shankar, X. Wang, and B. Ateeq Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer Science 322 5908 2008 1695 1699
    • (2008) Science , vol.322 , Issue.5908 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3    Shankar, S.4    Wang, X.5    Ateeq, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.