Identification of nonproliferating but viable hypoxic tumor cells in vivo

Cancer Research

Volumn 58, Issue 16, 1998, Pages 3547-3550

  Durand, Ralph E ^a   Raleigh, James A ^b  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; HOE 33342; PIMONIDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL HYPOXIA; CELL LABELING; CELL PROLIFERATION; CELL SELECTION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA;

ANIMALS; BROMODEOXYURIDINE; CELL DIVISION; CELL HYPOXIA; CELL SEPARATION; FLOW CYTOMETRY; HUMANS; MICE; MICE, SCID; NEOPLASMS; NITROIMIDAZOLES; RADIATION-SENSITIZING AGENTS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0032529245     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Churchill-Davidson, I., Chir, B., Foster, C. A., Wiemik, G., Collins, C. D., Pizey, N. C. D., Skeggs, D. B. L., and Purser, P. R. The place of oxygen in radiotherapy. Br. J. Radiol., 39: 321-331, 1966.
2. Henk, J. M., Kunkler, P. B., and Smith, C. W. Radiotherapy and hyperbaric oxygen in head and neck cancer. Lancet, 2: 101-105, 1977.
3. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., and Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56: 4509-4515, 1996.
4. Gatenby, R. A., Kessler, H. B., Rosenblum, J. S., Coia, L. R., Moldofsky, R. J., Hartz, W. H., and Broder, G. J. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 14: 831-838, 1988.
5. Olive, P. L., Johnston, P. J., Banáth, J. P., and Durand, R. E. The comet assay: a new method to examine heterogeneity associated with solid tumors. Nat. Med., 4: 103-105, 1998.
6. Chapman, J. D., Franko, A. J., and Sharplin, J. A marker for hypoxic cells in tumors with potential clinical applicability. Br. J. Cancer, 43: 546-550, 1981.
7. Koh, W., Rasey, J. S., Evans, M. L., Grierson, J. R., Lewellen, T. K., Graham, M. M., Krohn, K. A., and Griffin, T. W. Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole. Int. J. Radiat. Oncol. Biol. Phys., 22: 199-212, 1992.
8. Urtasun, R. C., Parliament, M. B., McEwan, A. J., Mercer, J. R., Mannan, R. H., Wiebe, L. I., Morin, C., and Chapman, J. D. Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside. Br. J. Cancer, 74: S209-S212, 1996.
9. Raleigh, J. A., Miller, G. G., Franko, A. J., Koch, C. J., Fuciarelli, A. F., and Kelly, D. A. Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours. Br. J. Cancer, 56: 395-400, 1987.
10. Cline, J. M., Thrall, D. E., Rosner, G. L., and Raleigh, J. A. Distribution of the hypoxia marker CCI-103F in canine tumors. Int. J. Radiat. Oncol. Biol. Phys., 28: 921-933, 1994.
11. Arteel, G. E., Thurman, R. G., Yates, J. M., and Raleigh, J. A. Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer, 72: 889-895, 1995.
12. Koch, C. J., Evans, S. M., and Lord, E. M. Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-y1)-N-(2,2,3,3,3-pentafluoropropyl)acetamide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br. J. Cancer, 72: 869-874, 1995.
13. Kennedy, A. S., Raleigh, J. A., Perez, G. M., Calkins, D. P., Thrall, D. E., Novotny, D. B., and Varia, M. A. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int. J. Radiat. Oncol. Biol. Phys., 37: 897-905, 1997.
14. Durand, R. E. Use of a cell sorter for assays of cell clonogenicity. Cancer Res., 46: 2775-2778, 1986.
15. Durand, R. E., and LePard, N. E. Tumour blood flow influences combined radiation and doxorubicin treatments. Radiother. Oncol., 42: 171-179, 1997.
16. pot in heterogeneous systems: a new approach illustrated with multicell spheroids. Cytometry, 14: 527-534, 1993.
17. Chaplin, D. J., Olive, P. L., and Durand, R. E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res., 47: 597-601, 1987.
18. Coleman, C. N. Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity. J. Natl. Cancer Inst., 80: 310-317, 1988.
19. Webster, L., Hodgkiss, R. J., and Wilson, G. D. Simultaneous triple staining for hypoxia, proliferation, and DNA content in murine tumours. Cytometry, 21: 344-351, 1995.
20. Chaplin, D. J., and Horsman, M. R. Tumor blood flow changes induced by chemical modifiers of radiation response. Int. J. Radiat. Oncol. Biol. Phys., 22: 459-462, 1992.