-
1
-
-
0023736971
-
UKCCCR guidelines for the welfare of animals in experimental neoplasia
-
Anon
-
Anon (1988) UKCCCR guidelines for the welfare of animals in experimental neoplasia. Br J Cancer 58: 109-113
-
(1988)
Br J Cancer
, vol.58
, pp. 109-113
-
-
-
2
-
-
0026786660
-
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: Implications for vascular collapse
-
Boucher Y, Jain RK (1992) Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res 52: 5110-5114
-
(1992)
Cancer Res
, vol.52
, pp. 5110-5114
-
-
Boucher, Y.1
Jain, R.K.2
-
3
-
-
0025334830
-
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy
-
Boucher Y, Baxter LT, Jain RK (1990) Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 50: 4478-4484
-
(1990)
Cancer Res
, vol.50
, pp. 4478-4484
-
-
Boucher, Y.1
Baxter, L.T.2
Jain, R.K.3
-
4
-
-
0028968622
-
Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
-
Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, Lydon NB (1995) Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci USA 92: 2558-2562
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2558-2562
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
Meyer, T.4
Muller, M.5
Regenass, U.6
Lydon, N.B.7
-
5
-
-
0022256289
-
Method for determination of 4′-deoxydoxorubicin, 4′-deoxydoxorubicinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography
-
Cummings J (1985) Method for determination of 4′-deoxydoxorubicin, 4′-deoxydoxorubicinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography. J Chromatogr 341: 401-409
-
(1985)
J Chromatogr
, vol.341
, pp. 401-409
-
-
Cummings, J.1
-
6
-
-
16544382996
-
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
-
Furuhashi M, Sjoblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A (2004) Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res 64: 2725-2733
-
(2004)
Cancer Res
, vol.64
, pp. 2725-2733
-
-
Furuhashi, M.1
Sjoblom, T.2
Abramsson, A.3
Ellingsen, J.4
Micke, P.5
Li, H.6
Bergsten-Folestad, E.7
Eriksson, U.8
Heuchel, R.9
Betsholtz, C.10
Heldin, C.H.11
Ostman, A.12
-
7
-
-
0141645497
-
Targeting PDGF receptors in cancer - rationales and proof of concept clinical trials
-
George D (2003) Targeting PDGF receptors in cancer - rationales and proof of concept clinical trials. Adv Exp Med Biol 532: 141-151
-
(2003)
Adv Exp Med Biol
, vol.532
, pp. 141-151
-
-
George, D.1
-
8
-
-
0042342564
-
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer
-
George DJ, Kaelin Jr WG (2003) The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 349: 419-421
-
(2003)
N Engl J Med
, vol.349
, pp. 419-421
-
-
George, D.J.1
Kaelin Jr, W.G.2
-
9
-
-
0033178578
-
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: Clinical implications
-
Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK (1999) Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res 59: 3776-3782
-
(1999)
Cancer Res
, vol.59
, pp. 3776-3782
-
-
Griffon-Etienne, G.1
Boucher, Y.2
Brekken, C.3
Suit, H.D.4
Jain, R.K.5
-
10
-
-
4944266313
-
High interstitial fluid pressure - an obstacle in cancer therapy
-
Heldin CH, Rubin K, Pietras K, Ostman A (2004) High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 4: 806-813
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 806-813
-
-
Heldin, C.H.1
Rubin, K.2
Pietras, K.3
Ostman, A.4
-
11
-
-
0033613119
-
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling
-
Heuchel R, Berg A, Tallquist M, Ahlen K, Reed RK, Rubin K, Claesson-Welsh L, Heldin CH, Soriano P (1999) Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling. Proc Natl Acad Sci USA 96: 11410-11415
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11410-11415
-
-
Heuchel, R.1
Berg, A.2
Tallquist, M.3
Ahlen, K.4
Reed, R.K.5
Rubin, K.6
Claesson-Welsh, L.7
Heldin, C.H.8
Soriano, P.9
-
12
-
-
0030198988
-
1995 Whitaker Lecture: Delivery of molecules, particles, and cells to solid tumors
-
Jain RK (1996) 1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors. Ann Biomed Eng 24: 457-473
-
(1996)
Ann Biomed Eng
, vol.24
, pp. 457-473
-
-
Jain, R.K.1
-
13
-
-
0035291243
-
Delivery of molecular and cellular medicine to solid tumors
-
Jain RK (2001) Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev 46: 149-168
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 149-168
-
-
Jain, R.K.1
-
14
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
15
-
-
0024232289
-
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
-
Jain RK, Baxter LT (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 48: 7022-7032
-
(1988)
Cancer Res
, vol.48
, pp. 7022-7032
-
-
Jain, R.K.1
Baxter, L.T.2
-
16
-
-
0030725954
-
Expression in lung carcinomas of platelet-derived growth factor and its receptors
-
Kawai T, Hiroi S, Torikata C (1997) Expression in lung carcinomas of platelet-derived growth factor and its receptors. Lab Invest 77: 431-436
-
(1997)
Lab Invest
, vol.77
, pp. 431-436
-
-
Kawai, T.1
Hiroi, S.2
Torikata, C.3
-
17
-
-
3042523539
-
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice
-
Kim SJ, Uehara H, Yazici S, Langley RR, He J, Tsan R, Fan D, Killion JJ, Fidler IJ (2004) Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Cancer Res 64: 4201-4208
-
(2004)
Cancer Res
, vol.64
, pp. 4201-4208
-
-
Kim, S.J.1
Uehara, H.2
Yazici, S.3
Langley, R.R.4
He, J.5
Tsan, R.6
Fan, D.7
Killion, J.J.8
Fidler, I.J.9
-
18
-
-
0034671219
-
Efficacy of liposomes and hyperthermia in a human tumor xenograft model: Importance of triggered drug release
-
Kong G, Anyarambhatla G, Petros WP, Braun RD, Colvin OM, Needham D, Dewhirst MW (2000) Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res 60: 6950-6957
-
(2000)
Cancer Res
, vol.60
, pp. 6950-6957
-
-
Kong, G.1
Anyarambhatla, G.2
Petros, W.P.3
Braun, R.D.4
Colvin, O.M.5
Needham, D.6
Dewhirst, M.W.7
-
19
-
-
0842311601
-
Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation
-
Matei D, Chang DD, Jeng MH (2004) Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation. Clin Cancer Res 10: 681-690
-
(2004)
Clin Cancer Res
, vol.10
, pp. 681-690
-
-
Matei, D.1
Chang, D.D.2
Jeng, M.H.3
-
20
-
-
13044292648
-
Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
-
Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK (1999) Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci USA 96: 3137-3142
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3137-3142
-
-
Netti, P.A.1
Hamberg, L.M.2
Babich, J.W.3
Kierstead, D.4
Graham, W.5
Hunter, G.J.6
Wolf, G.L.7
Fischman, A.8
Boucher, Y.9
Jain, R.K.10
-
21
-
-
2942670180
-
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
-
Ostman A (2004) PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15: 275-286
-
(2004)
Cytokine Growth Factor Rev
, vol.15
, pp. 275-286
-
-
Ostman, A.1
-
22
-
-
0035297541
-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K, Ostman A, Sjoquist M, Buchdunger E, Reed RK, Heldin CH, Rubin K (2001) Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 61: 2929-2934
-
(2001)
Cancer Res
, vol.61
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.H.6
Rubin, K.7
-
23
-
-
85047686581
-
Magnetic resonance imaging of temperature-sensitive liposome release: Drug dose painting and antitumor effects
-
Ponce AM, Viglianti BL, Yu D, Yarmolenko PS, Michelich CR, Woo J, Bally MB, Dewhirst MW (2007) Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. J Natl Cancer Inst 99: 53-63
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 53-63
-
-
Ponce, A.M.1
Viglianti, B.L.2
Yu, D.3
Yarmolenko, P.S.4
Michelich, C.R.5
Woo, J.6
Bally, M.B.7
Dewhirst, M.W.8
-
24
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346: 92-98
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
Langer, C.4
Sandler, A.5
Krook, J.6
Zhu, J.7
Johnson, D.H.8
-
25
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK (2004) Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64: 3731-3736
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
27
-
-
2942753811
-
In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: Illustration of targeted delivery
-
Viglianti BL, Abraham SA, Michelich CR, Yarmolenko PS, MacFall JR, Bally MB, Dewhirst MW (2004) In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn Reson Med 51: 1153-1162
-
(2004)
Magn Reson Med
, vol.51
, pp. 1153-1162
-
-
Viglianti, B.L.1
Abraham, S.A.2
Michelich, C.R.3
Yarmolenko, P.S.4
MacFall, J.R.5
Bally, M.B.6
Dewhirst, M.W.7
-
28
-
-
33750209783
-
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation
-
Vlahovic G, Rabbani ZN, Herndon II JE, Dewhirst MW, Vujaskovic Z (2006) Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation. Br J Cancer 95: 1013-1019
-
(2006)
Br J Cancer
, vol.95
, pp. 1013-1019
-
-
Vlahovic, G.1
Rabbani, Z.N.2
Herndon II, J.E.3
Dewhirst, M.W.4
Vujaskovic, Z.5
-
29
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10: 145-147
-
(2004)
Nat Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
di Tomaso, E.3
Duda, D.G.4
Munn, L.L.5
Tong, R.T.6
Chung, D.C.7
Sahani, D.V.8
Kalva, S.P.9
Kozin, S.V.10
Mino, M.11
Cohen, K.S.12
Scadden, D.T.13
Hartford, A.C.14
Fischman, A.J.15
Clark, J.W.16
Ryan, D.P.17
Zhu, A.X.18
Blaszkowsky, L.S.19
Chen, H.X.20
Shellito, P.C.21
Lauwers, G.Y.22
Jain, R.K.23
more..
-
30
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK (2004) Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6: 553-563
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
Xu, L.7
Hicklin, D.J.8
Fukumura, D.9
di Tomaso, E.10
Munn, L.L.11
Jain, R.K.12
-
31
-
-
0031903379
-
Transvascular drug delivery in solid tumors
-
Yuan F (1998) Transvascular drug delivery in solid tumors. Semin Radiat Oncol 8: 164-175
-
(1998)
Semin Radiat Oncol
, vol.8
, pp. 164-175
-
-
Yuan, F.1
-
32
-
-
0029150245
-
Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
-
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK (1995) Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 55: 3752-3756
-
(1995)
Cancer Res
, vol.55
, pp. 3752-3756
-
-
Yuan, F.1
Dellian, M.2
Fukumura, D.3
Leunig, M.4
Berk, D.A.5
Torchilin, V.P.6
Jain, R.K.7
-
33
-
-
0028304405
-
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
-
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK (1994) Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res 54: 3352-3356
-
(1994)
Cancer Res
, vol.54
, pp. 3352-3356
-
-
Yuan, F.1
Leunig, M.2
Huang, S.K.3
Berk, D.A.4
Papahadjopoulos, D.5
Jain, R.K.6
|