The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane

International Immunology

Volumn 26, Issue 6, 2014, Pages 307-314

  Tanimura, Natsuko ^a,b   Saitoh, Shin Ichiroh ^a   Ohto, Umeharu ^a   Akashi Takamura, Sachiko ^a   Fujimoto, Yukari ^c   Fukase, Koichi ^c   Shimizu, Toshiyuki ^a   Miyake, Kensuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

CD14; LBP; MPL; TLR4 MD 2

Indexed keywords

BETA INTERFERON; CD14 ANTIGEN; CD86 ANTIGEN; LIPID A; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYL LIPID A; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; ACUTE PHASE PROTEIN; BLOCKING ANTIBODY; CARRIER PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN; TICAM1 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DIMERIZATION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM;

ACUTE-PHASE PROTEINS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD14; ANTIGENS, CD86; CARRIER PROTEINS; CELL MEMBRANE; CELLS, CULTURED; DENDRITIC CELLS; DIMERIZATION; INFLAMMATION; LIPID A; LYMPHOCYTE ANTIGEN 96; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84901488030     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt071     Document Type: Article

References (27)

1. Perera, P. Y., Vogel, S. N., Detore, G. R., Haziot, A. and Goyert, S. M. 1997. CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol. J. Immunol. 158:4422.
2. Jiang, Z., Georgel, P., Du, X. et al. 2005. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6:565.
3. Jack, R. S., Fan, X., Bernheiden, M. et al. 1997. Lipopolysaccharidebinding protein is required to combat a murine gram-negative bacterial infection. Nature 389:742.
4. Wurfel, M. M., Monks, B. G., Ingalls, R. R. et al. 1997. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J. Exp. Med. 186:2051.
5. Ohto, U., Fukase, K., Miyake, K. and Satow, Y. 2007. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316:1632.
6. Park, B. S., Song, D. H., Kim, H. M., Choi, B. S., Lee, H. and Lee, J. O. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458:1191.
7. Kobayashi, M., Saitoh, S., Tanimura, N. et al. 2006. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J. Immunol. 176:6211.
8. Kim, H. M., Park, B. S., Kim, J. I. et al. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906.
9. Kagan, J. C. and Medzhitov, R. 2006. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125:943.
10. Aksoy, E., Taboubi, S., Torres, D. et al. 2012. The p110d isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat. Immunol. 13:1045.
11. Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S. and Medzhitov, R. 2008. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 9:361.
12. Tanimura, N., Saitoh, S., Matsumoto, F., Akashi-Takamura, S. and Miyake, K. 2008. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem. Biophys. Res. Commun. 368:94.
13. Yamamoto, M., Sato, S., Hemmi, H. et al. 2003. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301:640.
14. Saitoh, S., Akashi, S., Yamada, T. et al. 2004. Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int. Immunol. 16:961.
15. Zanoni, I., Ostuni, R., Marek, L. R. et al. 2011. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147:868.
16. Mata-Haro, V., Cekic, C., Martin, M., Chilton, P. M., Casella, C. R. and Mitchell, T. C. 2007. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 316:1628.
17. Cekic, C., Casella, C. R., Eaves, C. A., Matsuzawa, A., Ichijo, H. and Mitchell, T. C. 2009. Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J. Biol. Chem. 284:31982.
18. Casella, C. R. and Mitchell, T. C. 2013. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS One 8:e62622.
19. Yamakawa, N., Ohto, U., Akashi-Takamura, S. et al. 2013. Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. Int. Immunol. 25:45.
20. Moore, K. J., Andersson, L. P., Ingalls, R. R. et al. 2000. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J. Immunol. 165:4272.
21. Nagai, Y., Akashi, S., Nagafuku, M. et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667.
22. Le Roy, D., Di Padova, F., Tees, R. et al. 1999. Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14. J. Immunol. 162:7454.
23. Hailman, E., Lichenstein, H. S., Wurfel, M. M. et al. 1994. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J. Exp. Med. 179:269.
24. West, A. P., Brodsky, I. E., Rahner, C. 2011. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472:476.
25. Vicinanza, M., D'Angelo, G., Di Campli, A. and De Matteis, M. A. 2008. Function and dysfunction of the PI system in membrane trafficking. EMBO J. 27:2457.
26. Núñez Miguel, R., Wong, J., Westoll, J. F. et al. 2007. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One 2:e788.
27. Legat, A., Thomas, S., Hermand, P., Van Mechelen, M., Goldman, M. and De Wit, D. 2010. CD14-independent responses induced by a synthetic lipid A mimetic. Eur. J. Immunol. 40:797.