Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7454-7460

  Le Roy, Didier ^a   Di Padova, Franco ^b   Tees, Reet ^b   Lengacher, Sylvain ^c   Landmann, Regine ^d   Glauser, Michel Pierre ^a   Calandra, Thierry ^a   Heumann, Didier ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD14 ANTIGEN; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CELL PROTECTION; CELLULAR IMMUNITY; COMPLEX FORMATION; CYTOKINE PRODUCTION; ENDOTOXEMIA; HOST RESISTANCE; LIPID TRANSPORT; MEMBRANE BINDING; MOLECULAR CLONING; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING;

EID: 0033564345     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ulevitch, R. J., and P. S. Tobias. 1994. Recognition of endotoxin by cells leading to transmembrane signaling. Curr. Biol. 6:125.
2. Heumann, D., P. Gallay, C. Barras, P. Zaech, R. J. Ulevitch, P. S. Tobias, M. P. Glauser, and J. D. Baumgartner. 1992. Control of LPS binding and LPS-induced TNF secretion in human peripheral blood monocytes. J. Immunol. 148: 3505.
3. Wurfel, M. M., E. Hailman, and S. D. Wright. 1995. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. J. Exp. Med. 181:1743.
4. Yu, B., E. Hailman, and S. D. Wright. 1997. Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids. J. Clin. Invest. 99:315.
5. Park, C. T., and S. D. Wright. 1996. Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. J. Biol. Chem. 271:18054.
6. Wurfel, M. M., and S. D. Wright. 1997. Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid. J. Immunol. 158:3925.
7. Yu, B., and S. D. Wright. 1996. Catalytic properties of lipopolysaccharide (LPS) binding protein. J. Biol. Chem. 271:4100.
8. Wurfel, M. M., S. T. Kunitake, H. Lichenstein, J. P. Kane, and S. D. Wright. 1994. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J. Exp. Med. 180:1025.
9. Schumann, R. R., S. R. Leong, G. W. Flaggs, P. W. Gray, S. D. Wright, J. C. Mathison, P. S. Tobias, and R. J. Ulevitch. 1990. Structure and function of lipopolysaccharide binding protein. Science 249:1429.
10. Gallay, P., D. Heumann, D. Le Roy, C. Barras, and M. P. Glauser. 1993. Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock. Proc. Natl. Acad. Sci. USA 90:9935.
11. Gallay, P., D. Heumann, D. Le Roy, C. Barras, and M. P. Glauser. 1994. Mode of action of anti-lipopolysaccharide binding protein (LBP) antibodies for prevention of endotoxemic shock in mice. Proc. Natl. Acad. Sci. USA 91:7922.
12. Jack, R. S., X. L. Fan, M. Bernheiden, G. Rune, M. Ehlers, A. Weber, G. Kirsch, R. Mentel, B. Furll, M. Freudenberg, et al. 1997. Lipopolysaccharide-binding protein is required to combat a Gram-negative bacterial infection. Nature 389:742.
13. Wurfel, M. M., B. G. Monks, R. R. Ingalls, R. L. Dedrick, R. Delude, D. Zhou, N. Lamping, R. R. Schumann, R. Thieringer, M. J. Fenton, S. D. Wright, and D. Golenbock. 1997. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J. Exp. Med. 186:2051.
14. Lamping, N., R. Dettmer, W. J. Schröder, D. Pfeil, W. Hallatschek, and R. R. Schumann. 1998. LPS-binding protein protects mice from septic shock caused by LPS or Gram-negative bacteria. J. Clin. Invest. 101:2065.
15. Lengacher, S., C. V. Jongeneel, D. Le Roy, J. D. Lee, V. Kravtchenko, R. J. Ulevitch, M. P. Glauser, and D. Heumann. 1996. Reactivity of murine and human recombinant LPS-binding protein (LBP) with LPS and Gram negative bacteria. J. Inflamm. 47:165.
16. Theofan, G., A. H. Horwitz, R. E. Williams, P. S. Liu, I. Chan, C. Birr, S. F. Carroll, K. Meszaros, J. B. Parent, H. Kasler, et al. 1994. An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J. Immunol. 152:3623.
17. Gegner, J. A., R. J. Ulevitch, and P. S. Tobias. 1995. Lipopolysaccharide (LPS) signal transduction and clearance. J. Biol. Chem. 270:5320.
18. Stocker, J. W., H. K. Forster, V. Miggiano, C. Stahli, G. Stalger, B. Takavcs, and T. Staehlin. 1982. Research Disclosure, May 1982-Nr.21713. Ciba-Geigy.
19. Delude, R. L., M. J. Fenton, R. Savedra, P. Y. Perera, S. N. Vogel, R. Thieringer, and D. T. Golenbock. 1994. CD14-mediated translocation of nuclear factor-κB induced by lipopolysaccharide does not require tyrosine kinase activity. J. Biol. Chem. 269:22253.
20. Tobias, P. S., K. Soldau, and R. J. Ulevitch. 1989. Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J. Biol. Chem. 264:10867.
21. Skelly, R. R., P. Munkenbeck, and D. C. Morrison. 1979. Stimulation of T-independent antibody responses by hapten-lipopolysaccharides without repeating polymeric structure. Infect. Immun. 23:287.
22. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431.
23. Beamer, L. J., S. F. Carroll, and D. Eisenberg. 1998. The BPI/LBP family of proteins: a structural analysis of conserved regions. Protein Sci. 7:906.
24. Amura, C. R., L. C. Chen, N. Hirohashi, M. G. Lei, and D. C. Morrison. 1998. Functionally independent pathways for lipopolysaccharide-dependent activation of mouse peritoneal macrophages. J. Immunol. 159:5079.
25. Perera, P. Y., N. Qureshi, W. J. Christ, P. Stütz, and S. N. Vogel. 1998. Lipopolysaccharide and its analog antagonists display differential factor dependencies for induction of cytokine in murine macrophages. Infect. Immun. 66:2562.