Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A

International Immunology

Volumn 25, Issue 1, 2013, Pages 45-52

  Yamakawa, Natsuko ^a   Ohto, Umeharu ^a   Akashi Takamura, Sachiko ^a   Takahashi, Koichiro ^a   Saitoh, Shin Ichiroh ^a   Tanimura, Natsuko ^a   Suganami, Takayoshi ^b   Ogawa, Yoshihiro ^b   Shibata, Takuma ^a   Shimizu, Toshiyuki ^a   Miyake, Kensuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Human TLR4; MPL; Polymorphism

Indexed keywords

ASPARAGINE; BACTERIUM LIPOPOLYSACCHARIDE; GLYCINE; ISOLEUCINE; MONOCLONAL ANTIBODY; PHOSPHORYL LIPID A; PROTEIN MD 2; RECEPTOR ANTIBODY; THREONINE; TOLL LIKE RECEPTOR 4;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL IMMUNITY; CELL STIMULATION; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIPID A; LUCIFERASES; LYMPHOCYTE ANTIGEN 96; MICE; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84872149610     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs084     Document Type: Article

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