Two dipolar α-helices within hormone-encoding regions of proglucagon are sorting signals to the regulated secretory pathway

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 14968-14980

  Guizzetti, Leonardo ^a   McGirr, Rebecca ^b   Dhanvantari, Savita ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDES;

CONTEXT DEPENDENT; SECRETORY GRANULES; SECRETORY PATHWAYS; SORTING SIGNALS;

ENCODING (SYMBOLS);

GLUCAGON LIKE PEPTIDE 1; PROGLUCAGON; SIGNAL PEPTIDE;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; L CELL LINE; NEUROSECRETORY CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN TARGETING; SECRETORY GRANULE; STRUCTURE ACTIVITY RELATION;

CONFOCAL MICROSCOPY; DIPOLAR Α-HELIX; GLP-1; GLUCAGON; INTRACELLULAR TRAFFICKING; PEPTIDE HORMONES; PROGLUCAGON; PROTEIN SECRETION; PROTEIN SORTING; SECRETORY GRANULES;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; MESOCRICETUS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PC12 CELLS; PEPTIDES; PROGLUCAGON; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RATS; SECRETORY PATHWAY; SECRETORY VESICLES; SIGNAL TRANSDUCTION;

EID: 84901457013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.563684     Document Type: Article

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