Immunohistochemical staining of human islet cells with region-specific antibodies against secretogranins II and III

Journal of Anatomy

Volumn 212, Issue 3, 2008, Pages 229-234

  Stridsberg, Mats ^a   Grimelius, L ^a   Portela Gomes, G M ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

Antibodies; Co localization; Immunostaining; Peptides; Secretogranin; Secretoneurin

Indexed keywords

EPITOPE; GLUCAGON; INSULIN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; POLYPEPTIDE; PROTEIN DERIVATIVE; SECRETOGRANIN II; SECRETOGRANIN III; SECRETONEURIN; SOMATOSTATIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL TYPE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 40149096514     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2008.00857.x     Document Type: Article

References (23)

1. Dunzendorfer S, Schratzberger P, Reinisch N, Kähler CM, Wiedermann CJ (1998) Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils. Blood 91, 1527–1532.
2. Helle KB (2004) The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects. Biol Rev Camb Philos Soc 79, 769–794.
3. Holthuis JCM, Martens GJM (1996) The neuroendocrine proteins secretogranin II and III are regionally conserved and coordinately expressed with proopiomelanocortin in Xenopus intermediate pituitary. Journal of Neurochemistry 66, 2248–2256.
4. Hosaka M, Watanabe T, Sakai Y, et al. (2002) Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta‐cells. Mol Biol Cell 13, 3388–3399.
5. Ischia R, Gasser RW, Fischer‐Colbrie R, Uchiyama Y, Takeuchi T (2000) Levels and molecular properties of secretoneurin‐immunoreactivity in the serum and urine of control and neuroendocrine tumor patients. J Clin Endocrinol Metab 85, 355–360.
6. Kahler CM, Schratzberger P, Wiedermann CJ (1997) Response of vascular smooth muscle cells to the neuropeptide secretoneurin. A functional role for migration and proliferation in vitro. Arterioscler Thromb Vasc Biol 17, 2029–2035.
7. Kingsley DM, Rinchik EM, Russell LB, Ottiger HP, Sutcliffe JG, Copeland NG, et al. (1990) Genetic ablation of a mouse gene expressed specifically in brain. EMBO J 9, 395–400.
8. Kirchmair R, Hogue Angeletti R, Gutierrez J, Fischer Colbrie R, Winkler H (1993) Secretoneurin–a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C). Neuroscience 53, 359–365.
9. Marksteiner J, Kirchmair R, Mahata SK, Mahata M, Fischer‐Colbrie R, Hogue‐Angeletti R, et al. (1993) Distribution of secretoneurin, a peptide derived from secretogranin II, in rat brain: an immunocytochemical and radioimmunological study. Neuroscience 54, 923–944.
10. Ottiger HP, Battenberg EF, Tsou AP, Bloom FE, Sutcliffe JG (1990) 1B1075: A brain‐ and pituitary‐specific messenger RNA that encodes a novel chromogranin‐secretogranin‐like component of intracellular vesicles. J Neuroscience 10, 3135–3147.
11. Portela‐Gomes GM, Stridsberg M (2001) Selective processing of chromogranin A in the different islet cells in human pancreas. J Histochem Cytochem 49, 483–490.
12. Portela‐Gomes GM, Stridsberg M (2002) Region‐specific antibodies against chromogranin B display different immunoreactivity in the human pancreatic islet cell types. Ann NY Acad Sci 971, 341–344.
13. Portela‐Gomes GM, Stridsberg M, Johansson H, Grimelius L (1997) Complex co‐localization of chromogranins and neurohormones in the human gastrointestinal tract. J Histochem Cytochem 45, 815–822.
14. Portela‐Gomes GM, Stridsberg M, Grimelius L, Falkmer UG, Falkmer S (2004) Expression of chromogranins A, B, and C (secretogranin II) in human adrenal medulla and in benign and malignant pheochromocytomas An immunohistochemical study with region‐specific antibodies. APMIS 112, 663–673.
15. Reinisch N, Kirchmair R, Kähler CM, Hogure‐Angeletti R, Fischer‐Colbrie R, Wnkler H, et al. (1993) Attraction of human monocytes by the neuropeptide secretoneurin. FEBS Lett 334, 41–44.
16. Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T (2004) Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats. Arch Histol Cytol 67, 57–64.
17. Schmid KW, Brink M, Freytag G, Kirchmair R, Böcker W, Fischer‐Colbrie R, et al. (1994) Expression of chromogranin A and B and secretoneurin immunoreactivity in neoplastic and nonneoplastic pancreatic alpha cells. Virchows Arch 425, 127–132.
18. Schmid KW, Kunk B, Kirchmair R, Tötsch M, Böcker W, Fischer‐Colbrie R (1995) Immunohistochemical detection of secretoneurin, a novel neuropeptide endoproteolytically processed from secretogranin II, in normal human endocrine and neuronal tissues. Histochem J 27, 473–481.
19. Stridsberg M, Öberg K, Li Q, Engström U, Lundqvist G (1995) Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours. J Endocrinol 144, 49–59.
20. Stridsberg M, Eriksson B, Oberg K, Janson ET (2004) A panel of 11 region‐specific radioimmunoassays for measurements of human chromogranin A. Regul Pept 117, 219–227.
21. Stridsberg M, Eriksson B, Oberg K, Janson ET (2005) A panel of 13 region‐specific radioimmunoassays for measurements of human chromogranin B. Regul Pept 125, 193–199.
22. Taupenot L, Harper KL, O’Connor DT (2003) The chromogranin‐secretogranin family. N Engl J Med 348, 1134–1149.
23. You ZB, Saria A, Fischer‐Colbrie R, Terenius L, Goiny M, Herrera‐Marschitz M (1996) Effects of secretogranin II‐derived peptides on the release of neurotransmitters monitored in the basal ganglia of the rat with in vivo microdialysis. Naunyn-Schmiedebergs Arch Pharmacol 354, 717–724.