A prohormone convertase cleavage site within a predicted α-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway

Journal of Biological Chemistry

Volumn 280, Issue 50, 2005, Pages 41595-41608

  Garcia, Angelo L ^a   Han, Shan Kuo ^a   Janssen, William G ^a   Khaing, Zin Z ^a   Ito, Timothy ^a   Glucksman, Marc J ^b   Benson, Deanna L ^a   Salton, Stephen R J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ENZYME KINETICS; MOLECULAR DYNAMICS; NEUROLOGY; POLYPEPTIDES;

DELETIONAL ANALYSIS; ENDOCRINE POLYPEPTIDE; SOLUBLE PROTEINS; VESICLE MEMBRANES;

ENZYMES;

EPITOPE; FURIN; HORMONE PRECURSOR; NERVE PROTEIN; POLYPEPTIDE; UNCLASSIFIED DRUG; VALYLGLYCYLPHENYLALANINE;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CLINICAL PATHWAY; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; LIPID RAFT; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROHORMONE CONVERTASE CLEAVAGE SITE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; RAT; REGULATORY MECHANISM; SECRETORY VESICLE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; CENTRIFUGATION, DENSITY GRADIENT; CHROMOGRANINS; DETERGENTS; EPITOPES; GENE DELETION; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LIPIDS; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; NEURONS; NEUROPEPTIDES; PC12 CELLS; PEPTIDES; PLASMIDS; PROPROTEIN CONVERTASES; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 29244470261     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509122200     Document Type: Article

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