The crystal structure of dynamin

Nature

Volumn 477, Issue 7366, 2011, Pages 561-566

  Ford, Marijn G J ^a   Jenni, Simon ^b   Nunnari, Jodi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; DYNAMIN; DYNAMIN I; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; MEMBRANE; PHYLOGENETICS; PROTEIN; SIGNALING;

ARTICLE; CRYSTAL STRUCTURE; HUMAN; MUTATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAT; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS; YEAST;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DYNAMIN I; GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RATS;

HARNESS; MAMMALIA;

EID: 80053376521     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10441     Document Type: Article

References (43)

1. Praefcke, G. J. & McMahon, H. T. The dynamin superfamily: universal membrane tubulation and fission molecules? Nature Rev. Mol. Cell Biol. 5, 133-147 (2004). (Pubitemid 38160256)
2. Hoppins, S., Lackner, L. & Nunnari, J. The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 76, 751-780 (2007).
3. Marks, B. et al. GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature 410, 231-235 (2001). (Pubitemid 32216598)
4. Stowell, M. H. B., Marks, B., Wigge, P. & McMahon, H. T. Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring. Nature Cell Biol. 1, 27-32 (1999). (Pubitemid 129495006)
5. Mears, J. A. et al. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nature Struct. Mol. Biol. 18, 20-26 (2011).
6. Warnock, D. E., Hinshaw, J. E.& Schmid, S. L. Dynamin self-assembly stimulates its GTPase activity. J. Biol. Chem. 271, 22310-22314 (1996). (Pubitemid 26304660)
7. Danino, D., Moon, K. H. & Hinshaw, J. E. Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin. J. Struct. Biol. 147, 259-267 (2004). (Pubitemid 39140733)
8. Pucadyil, T. J. & Schmid, S. L. Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell 135, 1263-1275 (2008).
9. Chappie, J. S. et al. An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol. Biol. Cell 20, 3561-3571 (2009).
10. Chappie, J. S., Acharya, S., Leonard, M., Schmid, S. L. & Dyda, F. G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature 465, 435-440 (2010).
11. Timm, D. et al. Crystal structure of the pleckstrin homology domain fromdynamin. Nature Struct. Biol. 1, 782-788 (1994).
12. Achiriloaie, M., Barylko, B. & Albanesi, J. P. Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis. Mol. Cell. Biol. 19, 1410-1415 (1999). (Pubitemid 29046882)
13. Ferguson, K. M., Lemmon, M. A., Schlessinger, J. & Sigler, P. B. Crystal structure at 2.2A? resolution of the pleckstrin homology domain fromhumandynamin. Cell 79, 199-209 (1994).
14. Ramachandran, R. et al. Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol. Biol. Cell 20, 4630-4639 (2009).
15. Hinshaw, J. E. & Schmid, S. L. Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature 374, 190-192 (1995).
16. Ingerman, E. et al. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J. Cell Biol. 170, 1021-1027 (2005). (Pubitemid 41362634)
17. Mears, J. A., Ray, P. & Hinshaw, J. E. A corkscrew model for dynamin constriction. Structure 15, 1190-1202 (2007). (Pubitemid 47539167)
18. Gao, S. et al. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465, 502-506 (2010).
19. Low, H. H., Sachse, C., Amos, L. A. & Lowe, J. Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving. Cell 139, 1342-1352 (2009).
20. Low, H. H. & Lowe, J. A bacterial dynamin-like protein. Nature 444, 766-769 (2006). (Pubitemid 44949606)
21. Prakash, B., Praefcke, G. J., Renault, L., Wittinghofer, A.& Herrmann, C. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature 403, 567-571 (2000). (Pubitemid 30082205)
22. Ghosh, A., Praefcke, G. J., Renault, L., Wittinghofer, A. & Herrmann, C. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature 440, 101-104 (2006). (Pubitemid 43336275)
23. Bian, X. et al. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc. Natl Acad. Sci. USA 108, 3976-3981 (2011).
24. Byrnes, L. J. & Sondermann, H. Structural basis for the nucleotide-dependent dimerization of the largeGprotein atlastin-1/SPG3A. Proc.NatlAcad. Sci.USA108, 2216-2221 (2011).
25. Zhang, P. & Hinshaw, J. E. Three-dimensional reconstruction of dynamin in the constricted state. Nature Cell Biol. 3, 922-926 (2001). (Pubitemid 32952258)
26. Siegel, L. M.& Monty, K. J. Determination ofmolecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. Biochim. Biophys. Acta 112, 346-362 (1966).
27. Ramachandran, R. et al. The dynamin middle domain is critical for tetramerization and higher-order self-assembly. EMBO J. 26, 559-566 (2007). (Pubitemid 46160955)
28. Gao, S. et al. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465, 502-506 (2010).
29. Song, B. D., Yarar, D.&Schmid, S. L. An assembly-incompetentmutant establishes a requirement for dynaminself-assembly in clathrin-mediated endocytosis in vivo. Mol. Biol. Cell 15, 2243-2252 (2004). (Pubitemid 38580642)
30. Reubold, T. F. et al. Crystal structure of the GTPase domain of rat dynamin 1. Proc. Natl Acad. Sci. USA 102, 13093-13098 (2005). (Pubitemid 41324984)
31. Sweitzer, S. M. & Hinshaw, J. E. Dynamin undergoes a GTP-dependent conformational change causing vesiculation. Cell 93, 1021-1029 (1998). (Pubitemid 28280795)
32. Bashkirov, P. V. et al. GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell 135, 1276-1286 (2008).
33. Kenniston, J. A. & Lemmon, M. A. Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients. EMBO J. 29, 3054-3067 (2010).
34. Niemann, H. H., Knetsch, M. L., Scherer, A., Manstein, D. J. & Kull, F. J. Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms. EMBO J. 20, 5813-5821 (2001). (Pubitemid 33049257)
35. Barylko, B. et al. The proline/arginine-rich domain is a major determinant of dynamin self-activation. Biochemistry 49, 10592-10594 (2010).
36. Vallis, Y., Wigge, P., Marks, B., Evans, P. R. & McMahon, H. T. Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis. Curr. Biol. 9, 257-263 (1999).
37. Durieux, A. C., Prudhon, B., Guicheney, P. & Bitoun, M. Dynamin 2 and human diseases. J. Mol. Med. 88, 339-350 (2010).
38. Lackner, L. L.,Horner, J. S.&Nunnari, J.Mechanistic analysis of a dynamin effector. Science 325, 874-877 (2009).
39. Gandre-Babbe, S.&van der Bliek, A. M. Thenovel tail-anchoredmembrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19, 2402-2412 (2008).
40. Kosaka, T. & Ikeda, K. Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single genemutation in Drosophila. J. Neurobiol. 14, 207-225 (1983). (Pubitemid 13058761)
41. Ramaswami, M., Rao, S., van der Bliek, A., Kelly, R. B. & Krishnan, K. S. Genetic studies on dynamin function in Drosophila. J. Neurogenet. 9, 73-87 (1993). (Pubitemid 2030649)
42. Narayanan, R., Leonard, M., Song, B. D., Schmid, S. L.& Ramaswami, M. An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J. Cell Biol. 169, 117-126 (2005). (Pubitemid 40562919)
43. Ingerman, E. & Nunnari, J. A continuous, regenerative coupled GTPase assay for dynamin-related proteins. Methods Enzymol. 404, 611-619 (2005). (Pubitemid 43082019)