Alcohol selectivity of β3-containing GABAA receptors: Evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAa receptors

Neurochemical Research

Volumn 39, Issue 6, 2014, Pages 1118-1126

  Wallner, M ^a   Hanchar, H J ^a   Olsen, R W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol; Alcohol antagonist; Benzodiazepine; Tonic current

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA6; 4 AMINOBUTYRIC ACID A RECEPTOR BETA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; AMINO ACID; AZIDE; BENZODIAZEPINE DERIVATIVE; GABRB3 PROTEIN, RAT; PROTEIN SUBUNIT;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOL SENSITIVITY; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; NONHUMAN; OOCYTE; PHYSICAL SENSITIVITY; POINT MUTATION; PRIORITY JOURNAL; RAT; SEQUENCE ALIGNMENT; XENOPUS LAEVIS; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EXTRACELLULAR FLUID; FEMALE; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN SUBUNIT;

MUS; RATTUS;

ANIMALS; AZIDES; BENZODIAZEPINES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXTRACELLULAR FLUID; FEMALE; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 84901424344     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-014-1243-0     Document Type: Article

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