Selective GABAA α5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 8, 2005, Pages 1390-1401

  Cook, Jason B ^a   Foster, Katrina L ^a   Eiler II, William J A ^a   McKay, Peter F ^a   Woods II, James ^a   Harvey, Scott C ^b   Garcia, Marin ^a   Grey, Collette ^a   McCane, Shannan ^a   Mason, Dynesha ^a   Cummings, Rancia ^a   Li, Xiaoyan ^c   Cook, James M ^c   June, Harry L ^a  

^a INDIANA UNIVERSITY   (United States)

^b ACADIA PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Alcohol Reinforcement; Alcohol Sedation; Alcohol Preferring Rat; GABAA 5 receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5 ISOPROPOXY 4 METHYL BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; RY 023; SACCHARIN; TERT BUTYL 8 (TRIMETHYLSILYL)ACETYLENE 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLATE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; DRUGS USED IN THE TREATMENT OF ADDICTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT; REWARD; SEDATION; TASK PERFORMANCE; XENOPUS; ANIMAL; AROUSAL; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; MOTOR ACTIVITY; RAT STRAIN;

ALCOHOL DETERRENTS; ANIMALS; AROUSAL; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GABA ANTAGONISTS; HIPPOCAMPUS; MOTOR ACTIVITY; RATS; RATS, INBRED STRAINS; RECEPTORS, GABA-A;

EID: 24144486503     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000175073.94575.86     Document Type: Article

References (50)

1. Amaral DG, Witter, MP (1995) Hippocampal formation, in The Rat Central Nervous System, 2nd edition (Paxinos G, ed). pp. 443-494. Academic Press, San Diego, CA.
2. A receptor α3 and α4 subunits mRNAs in the rat brain. Mol Brain Res 12:295-314.
3. Barnard EA, Skolnick P, Olsen RW, Möhler W, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) International union of pharmacology, XV: Subtypes of γ-aminobutyric acid receptors: Classification on the basic of subunit structure and receptor function. Pharmacol Rev 50:291-313.
4. Canteras NS, Swanson LW (1992) Projection of the ventral subiculum to the amygdala, septum, hypothalamus: A PHA-L anterograde tract-tracing study in the rat. J Com. Neurol 324:180-194.
5. Carroll ME, Carmona G, May SA (1991) Modifying drug-reinforced behavior by altering the economics conditions of the drug and non-reinforcer. J Exp Anal Behav 56:361-376.
6. Dar MS. (1992) Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice. Pharmacol Biochem Behav 42:473-479.
7. Draski LJ, Deitrich RA (1996) Initial effects of ethanol on the central nervous system. In: Deitrich RA, Erwin VG (eds). Pharmacological Effects of Ethanol on the Nervous System, pp. 277-244. Boca Raton, FL: CRC Press.
8. Duka T, Stephens DN, Krause W, Dorow R (1987) Human studies on the benzodiazepine receptor antagonist beta-carboline, ZK 93 426: Preliminary observations on psychotropic activity. Psychopharmacology 93:421-427.
9. A receptors in the rat brain. Neuroscience 4:1113-1128.
10. A-α5-subunit ligand attenuates responding maintained by ethanol following microinjection into the CA1 and CA3 hippocampal areas. Alcohol Clin Exp Res 22:16A.
11. A-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
12. Groenewegen HJ, Vermeulen-Van Der Zee HE, Te Kortschot A, Witter MP (1987) Organization of the projections to the ventral striatum in the rat: A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience 23:103-120.
13. A receptors. Neuropharmacology 35:1307-1314.
14. Haefely W (1983) Antagonists of benzodiazepine: functional aspects. In: Biggio G, Costa E (eds). Benzodiazepine Site Ligands: Biochemistry and Pharmacology, pp. 22-34. New York, NY: Raven.
15. A-benzodiazepine receptor: Biology and pharmacology. In: Burrows GD, Roth M, Noyes R Jr (eds). Handbook of Anxiety, pp. 165-188. Amsterdam: Elsevier Science Publishers.
16. Harvey SC, McIntosh JM, Cartier GE, Maddox FN (1997) Determinants of alpha-conotoxin MII on a3b2 neuronal nicotinic receptors. Mol Pharmacol 51:336-342.
17. Jackson HC, Nutt DJ (1995) Inverse agonists and alcohol. In: Sarter M, Nutt DJ, Lister RG (eds). Benzodiazepine receptor inverse agonists, pp. 113-118. New York, NY: Wiley-Liss.
18. Jensen LH, Petersen EN, Braestrup C, Honore T, Kehr W, Stephens DN, Schneider H, Seidelmann D, Schmiechen R (1984) Evaluation of the beta-carboline ZK93 426 as a benzodiazepine receptor antagonist. Psychopharmacology 83:249-256.
19. June HL (2002) Preclinical models to evaluate potential pharmacotherapeutic agents in treating alcoholism and studying the neuropharmacological bases of alcohol-seeking behaviors in rats. In: Crawley J, Gerfen C, McKay R, Rogawski M, Sibley D, Skolnick P (eds). Current Protocols in Neuroscience. Unit 9.12, pp. 1-23. New York, NY: John Wiley & Sons, Inc.
20. A-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats. Brain Res 794:103-118.
21. June HL, Duemler S, Greene TL, Williams J, Lin M, Chen SHA, Lewis MJ, Murphy JM (1995) Effects of R019-4603 on the maintenance of tolerance to a single dose of ethanol. J Pharmacol Exp Ther 247:1105-1112.
22. June HL, Foster KL, McKay PF, Seyoum R, Woods JE II, Harvey SC, Eiler WJA II, Grey C, Carroll MR, McCane S, Jones CM, Wenyuan Y, Mason D, Cummings R, Garcia M, Chunrong M, Sarma PVVS, Cook JM, Skolnick P (2003) The reinforcing properties of alcohol are mediated by GABAAI receptors in the ventral pallidum. Neuropsychopharmacology 28:2124-2137.
23. A-receptors containing α5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: An extended ethanol reward circuitry. J Neurosci 21:2166-2177.
24. June HL, Zucarclli D, Craig KS, DeLong J, Cason CR, Torres L, Murphy JM (1998a) High affinity benzodiazepine antagonists reduce responding maintained by EtOH presentation in ethanol-preferring (P) rats. J Pharmacol Exp Ther 284:1006-1014.
25. Kelley A, Domesick VB (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience 7:2321-2335.
26. Koob GF, Braestrup C, Britton KT (1986) The effects of Ro-15-4513 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat. Psychopharmacology (Berlin) 90:173-178.
27. A receptor in the actions of alcohol and alcoholism. Alcohol Alcohol 29:115-129.
28. Lal H, Harris CM (1988) Central nervous system effects of Ro15-4513. Drug Dev Res 13:187-203.
29. Le AD, Israel Y (1994) A simple technique for quantifying intoxication-induced by low doses of ethanol. Pharmacol Biochem Behav 48:229-234.
30. A benzodiazepine receptors containing α1 and α5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology (Berlin) 161:180-188.
31. Liljequist S, Engel J (1982) Effects of GABAergic agonists and antagonists on various ethanol- induced behavioral changes. Psychopharmacology 64:61-65.
32. A receptors. J Med Med 39:1928-1934.
33. A receptor subtype. Med Chem Res 5:700-709.
34. Lumeng L, Murphy JM, McBride WJ, Li T-K (1995) Genetic influences on alcohol preference in animals. In: Begleiter H, Kissin B (eds). The Genetics of Alcoholism, pp. 165-201. New York, NY: Oxford University Press.
35. McBride WJ, Li T-K (1998) Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12: 339-369.
36. Meng Z, Dar MS (1994) Intrastriatal Ro 15-4513 functionally antagonizes ethanol-induced motor incoordination and striatal adenosinergic modulation of ethanol-induced motor incoordination in rats. J Pharmacol Exp Ther 271:524-534.
37. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates. Sydney: Academic Press.
38. Petry NM, Heyman GM (1995) Behavioral economic analysis of concurrent ethanol/sucrose and sucrose reinforcement in the rat: Effects of altering variable-ratio requirements. J Exp Anal Behav 64:331-359.
39. Phillipson OT, Griffiths AC (1985) Topographical order of inputs to the nucleus accumbens in the rat. Neuroscience 16:275-296.
40. Puia G, Stafano V, Seeburg PH, Costa E (1991) Influence of recombinant GABAa receptor subunit composition on the action of allosteric modulators of GABA-gated Cl- currents. Mol Pharmacol 39:691-696.
41. A receptor subtypes. Nature 401:796-800.
42. Samson HH (1987) Initiation of ethanol-maintained behavior: A comparison of animals models and their implication to human drinking. In: Thompson T, Dews PB, Barret J (eds). Advances in Behavioral Pharmacology: Neurobehavioral Pharmacology. Vol. 6, pp. 221-248. Academic Press, New York.
43. Samson HH, Haraguchi M, Tolliver GA, Sadeghi KG (1989) Antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonists RO15-4513 and FG 7142: relationship to sucrose reinforcement. Pharmacol Biochem Behav 33:601-608.
44. A receptors containing alpha-5 subunits. J Pharmacol Exp Ther 283:488-493.
45. A receptor in rat brain. Brain Res 822:265-270.
46. Suzdak P, Glowa JR, Crawley JN, Schwartz RD, Skolnick P, Paul SM (1986) A selective imidazodiazepine antagonist of ethanol in the rat. Science 234:1243-1247.
47. Turner JD, Bodewitz G, Thompson CL, Stephenson FA (1993) Immunohistochemical mapping of gamma-aminobutyric acid type-A receptor alpha subunits in rat central nervous system. In: Stephens DN (eds). Anxiolytic β-Carbolines: From Molecular Biology to the Clinic, pp. 29-49. New York, NY: Springer-Verlag.
48. Van Groen T, Wyss JM (1990) Extrinsic projections from Area CA1 of the rat hippocampus: olfactory, cortical, subcortical, and bilateral hippocampal formation projections. J Comp Neurol 302:515-528.
49. A/benzodiazepine receptors. Mol Pharmacol 44:437-442.
50. A receptor subunit mRNAs in the rat brain 1 Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062.