Physiology and pharmacology of alcohol: The imidazobenzodiazepine alcohol antagonist site on subtypes of GABA A receptors as an opportunity for drug development?

British Journal of Pharmacology

Volumn 154, Issue 2, 2008, Pages 288-298

  Wallner, M ^a   Olsen, R W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

carboline; Alcohol; Alcohol antagonist; Ro15 4513; Synthehol; Tonic GABA current

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 METHYLPYRAZOLE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ACETALDEHYDE; ALCOHOL; BETA CARBOLINE; BICUCULLINE; DRUG METABOLITE; FLUMAZENIL; INWARDLY RECTIFYING POTASSIUM CHANNEL; PICROTOXIN; RY 023; RY 024; RY 080; TRITIUM;

ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ALCOHOLISM; ANESTHESIA; BINDING AFFINITY; BINDING SITE; CEREBROVASCULAR ACCIDENT; CONCENTRATION (PARAMETERS); DRUG HALF LIFE; DRUG STRUCTURE; EMERGENCY WARD; HUMAN; HYPOTHERMIA; ISCHEMIC HEART DISEASE; METHANOL POISONING; MOTOR DYSFUNCTION; NONHUMAN; OXIDATIVE STRESS; PLEIOTROPY; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; REVIEW;

ACETALDEHYDE; ALCOHOLISM; ANIMALS; AZIDES; BEHAVIOR, ADDICTIVE; BENZODIAZEPINES; BINDING, COMPETITIVE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ETHANOL; GABA ANTAGONISTS; HUMANS; PROTEIN BINDING; RECEPTORS, GABA-A;

EID: 43449093743     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.32     Document Type: Review

References (131)