Structural requirements for imidazobenzodiazepine binding to GABAA receptors

Molecular Pharmacology

Volumn 63, Issue 2, 2003, Pages 289-296

  Kucken, Amy M ^a   Teissére, Jeremy A ^b   Seffinga Clark, James ^a   Wagner, David A ^a   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; FLUMAZENIL; FLUNITRAZEPAM; IMIDAZOBENZODIAZEPINE; MIDAZOLAM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; STRUCTURE ANALYSIS;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELLS, CULTURED; FLUMAZENIL; GABA MODULATORS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037308866     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.2.289     Document Type: Article

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