Oncogenes and the coagulation system - Forces that modulate dormant and aggressive states in cancer

Thrombosis Research

Volumn 133, Issue SUPPL. 2, 2014, Pages

  Magnus, Nathalie ^a   D'Asti, Esterina ^a   Meehan, Brian ^a   Garnier, Delphine ^a   Rak, Janusz ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Cancer; Coagulation; Dormancy; Glioma; Microparticles; Oncogenes; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LOW MOLECULAR WEIGHT HEPARIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE ACTIVATED RECEPTOR 1; PROTHROMBIN; SCATTER FACTOR RECEPTOR; VASCULOTROPIN; TRANSCRIPTOME;

ANGIOGENESIS; ANTICOAGULANT THERAPY; ARTICLE; BED REST; BLOOD CLOTTING; CANCER CELL; CELL GROWTH; CELL TRANSFORMATION; DISEASE COURSE; DNA METHYLATION; GENETIC REGULATION; GLIOBLASTOMA; HEMOSTASIS; HUMAN; INFLAMMATION; LIVER CELL CARCINOMA; MEDULLOBLASTOMA; METASTASIS; MITOGENESIS; NEOPLASM; NONHUMAN; ONCOGENE; ONCOGENE K RAS; ONCOGENE RAS; ONSET AGE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; VENOUS THROMBOEMBOLISM; ANIMAL; BLOOD; BRAIN TUMOR; CEREBELLUM TUMOR; GENETICS; GLIOMA; PATHOLOGY; PHYSIOLOGY; SECONDARY;

ANIMALS; BLOOD COAGULATION; BRAIN NEOPLASMS; CEREBELLAR NEOPLASMS; GLIOMA; HUMANS; MEDULLOBLASTOMA; ONCOGENES; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 84901391378     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/S0049-3848(14)50001-1     Document Type: Article

References (114)

1. H.F. Dvorak Tumors: wounds that do not heal N Engl J Med 315 1986 1650 1659
2. T. Browder, J. Folkman, and S. Pirie-Shepherd The haemostatic system as a regulator of angiogenesis J Biol Chem 275 2000 1521 1524
3. B. Dahlback Coagulation and inflammation - close allies in health and disease Semin Immunopathol 34 2012 1 3
4. V. Van Hinsbergh Endothelium - role in regulation of coagulation and inflammation Semin Immunopathol 34 2012 93 106
5. B.M. Mueller, R.A. Reisfeld, T.S. Edgington, and W. Ruf Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis Proc Natl Acad Sci U S A 89 1992 11832 11836 (Pubitemid 23004738)
6. W. Ruf Tissue factor and cancer Thromb Res 130 Suppl 1 2012 S84 S87
7. R.S. Kasthuri, M.B. Taubman, and N. Mackman Role of tissue factor in cancer J Clin Oncol 27 2009 4834 4838
8. F.R. Rickles Cancer and thrombosis in women - molecular mechanisms Thromb Res 123 Suppl 2 2009 S16 S20
9. B. Engelmann, and S. Massberg Thrombosis as an intravascular effector of innate immunity Nat Rev Immunol 13 2013 34 45
10. W. Ruf, J. Disse, T.C. Carneiro-Lobo, N. Yokota, and F. Schaffner Tissue factor and cell signalling in cancer progression and thrombosis J Thromb Haemost 9 Suppl 1 2011 306 315
11. C.T. Esmon Structure and functions of the endothelial cell protein C receptor Crit Care Med 32 2004 S298 S301
12. N. Mackman Triggers, targets and treatments for thrombosis Nature 451 2008 914 918 (Pubitemid 351301746)
13. M.T. Wiiger, and H. Prydz The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells Thromb Haemost 92 2004 13 22 (Pubitemid 39010864)
14. G. Lemke Biology of the TAM Receptors Cold Spring Harb Perspect Biol 5 2013 a009076
15. E. Camerer, E. Gjernes, M. Wiiger, S. Pringle, and H. Prydz Binding of factor VIIa to tissue factor on keratinocytes induces gene expression J Biol Chem 275 2000 6580 6585 (Pubitemid 30129959)
16. T. Albrektsen, B.B. Sorensen, G.M. Hjorto, J. Fleckner, L.V. Rao, and L.C. Petersen Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells J Thromb Haemost 5 2007 1588 1597 (Pubitemid 47091396)
17. K. Abe, M. Shoji, J. Chen, A. Bierhaus, I. Danave, and C. Micko et al. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor Proc Natl Acad Sci U S A 96 1999 8663 8668 (Pubitemid 29354848)
18. M.E. Bromberg, R. Sundaram, R.J. Homer, A. Garen, and W.H. Konigsberg Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule Thromb Haemost 82 1999 88 92 (Pubitemid 29368778)
19. T.A. McEachron, R. Pawlinski, K.L. Richards, F.C. Church, and N. Mackman Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis Blood 116 2010 5037 5044
20. A. Falanga, M. Marchetti, and A. Vignoli Coagulation and cancer: biological and clinical aspects J Thromb Haemost 11 2013 223 233
21. F.R. Rickles Mechanisms of cancer-induced thrombosis in cancer Pathophysiol Haemost Thromb 35 2006 103 110
22. A.A. Khorana, C.W. Francis, E. Culakova, N.M. Kuderer, and G.H. Lyman Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy J Thromb Haemost 5 2007 632 634 (Pubitemid 46680709)
23. H.T. Sorensen, L. Mellemkjaer, J.H. Olsen, and J.A. Baron Prognosis of cancers associated with venous thromboembolism N Engl J Med 343 2000 1846 1850 (Pubitemid 32104130)
24. J.R. Perry Thromboembolic disease in patients with high-grade glioma Neuro Oncol 14 Suppl 4 2012 iv73 iv80
25. J.L. Degen, and J.S. Palumbo Haemostatic factors, innate immunity and malignancy Thromb Res 129 Suppl 1 2012 S1 S5
26. J.E. Geddings, and N. Mackman Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients Blood 122 2013 1873 1880
27. F. Elice, F. Rodeghiero, A. Falanga, and F.R. Rickles Thrombosis associated with angiogenesis inhibitors Best Pract Res Clin Haematol 22 2009 115 128
28. J. Rak, C. Milsom, and J. Yu Tissue factor in cancer Curr Opin Hematol 15 2008 522 528
29. R. Beroukhim, C.H. Mermel, D. Porter, G. Wei, S. Raychaudhuri, and J. DonoVan et al. The landscape of somatic copy-number alteration across human cancers Nature 463 2010 899 905
30. T.H. Hwang, G. Atluri, R. Kuang, V. Kumar, T. Starr, and K.A. Silverstein et al. Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers BMC Genomics 14 2013 440
31. L. Omberg, K. Ellrott, Y. Yuan, C. Kandoth, C. Wong, and M.R. Kellen et al. Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas Nat Genet 45 2013 1121 1126
32. R.G. Verhaak, K.A. Hoadley, E. Purdom, V. Wang, Y. Qi, and M.D. Wilkerson et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 2010 98 110
33. K.T. Flaherty, F.S. Hodi, and D.E. Fisher From genes to drugs: targeted strategies for melanoma Nat Rev Cancer 12 2012 349 361
34. J. Folkman Angiogenesis: An organizing principle for drug discovery? Nat Rev Drug Discov 6 2007 273 286 (Pubitemid 46505878)
35. J. Rak, and G. Klement Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer Cancer Metastasis Rev 19 2000 93 96 (Pubitemid 32004698)
36. A. Alcalay, T. Wun, V. Khatri, H.K. Chew, D. Harvey, and H. Zhou et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival J Clin Oncol 24 2006 1112 1118 (Pubitemid 46638808)
37. T. Wun, and R.H. White Epidemiology of cancer-related venous thromboembolism Best Pract Res Clin Haematol 22 2009 9 23
38. P.D. Stein, A. Beemath, F.A. Meyers, E. Skaf, J. Sanchez, and R.E. Olson Incidence of venous thromboembolism in patients hospitalized with cancer Am J Med 119 2006 60 68 (Pubitemid 43117468)
39. B. Vogelstein, N. Papadopoulos, V.E. Velculescu, S. Zhou, L.A. Diaz Jr., and K.W. Kinzler Cancer genome landscapes Science 339 2013 1546 1558
40. J. Rak Ras oncogenes and tumor vascular interface A. Thomas-Tikhonenko, Cancer Genome and Tumor Microenvironment 2009 Springer New York 133 165
41. R.K. Jain, E. di Tomaso, D.G. Duda, J.S. Loeffler, A.G. Sorensen, and T.T. Batchelor Angiogenesis in brain tumors Nat Rev Neurosci 8 2007 610 622
42. J. Contrino, G. Hair, D.L. Kreutzer, and F.R. Rickles In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease Nat Med 2 1996 209 215 (Pubitemid 26054985)
43. F.H. Dvorak, and F.R. Rickles Malignancy and Hemostasis R.B. Coleman, V.J. Marder, A.W. Clowes, J.N. George, S.Z. Goldhaber, Hemostasis and Thrombosis: Basic Principles and Clinical Practice 2006 Lippincott Company Williams & Wilkins Philadelphia 851 873
44. K. Al-Nedawi, B. Meehan, and J. Rak Microvesicles: messengers and mediators of tumor progression Cell Cycle 8 2009 2014 2018
45. J. Rak, Y. Mitsuhashi, L. Bayko, J. Filmus, T. Sasazuki, and R.S. Kerbel Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis Cancer Res 55 1995 4575 4580
46. N. Bouck, V. Stellmach, and S.C. Hsu How tumors become angiogenic Adv Cancer Res 69 1996 135 174 (Pubitemid 26274885)
47. M. Relf, S. LeJeune, P.A. Scott, S. Fox, K. Smith, and R. Leek et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis Cancer Res 57 1997 963 969 (Pubitemid 27098025)
48. J. Rak, J. Filmus, and R.S. Kerbel Reciprocal paracrine interactions between tumor cells and endothelial cells. The "angiogenesis progression" hypothesis Eur J Cancer 32A 1996 2438 2450
49. D.J. Brat, and E.G. Van Meir Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma Lab Invest 84 2004 397 405 (Pubitemid 41656467)
50. A.M. Buccoliero, F. Castiglione, D.D. Rossi, A. Franchi, M. Paglierani, and M. Sanzo et al. Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation Neuropathology 30 2010 84 91
51. A. Sparmann, and D. Bar-Sagi Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis Cancer Cell 6 2004 447 458 (Pubitemid 39469981)
52. V.T. Phan, X. Wu, J.H. Cheng, R.X. Sheng, A.S. Chung, and G. Zhuang et al. Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment Proc Natl Acad Sci U S A 110 2013 6079 6084
53. I. Del Conde, C.N. Shrimpton, P. Thiagarajan, and J.A. Lopez Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation Blood 106 2005 1604 1611 (Pubitemid 41208572)
54. M. Demers, D.S. Krause, D. Schatzberg, K. Martinod, J.R. Voorhees, and T.A. Fuchs et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis Proc Natl Acad Sci U S A 109 2012 13076 13081
55. S. Koizume, N. Yokota, E. Miyagi, F. Hirahara, y. Nakamura, and Y. Sakuma et al. Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases Mol Cancer Res 7 2009 1928 1936
56. N. Magnus, D. Garnier, and J. Rak Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells Blood 116 2010 815 818
57. N. Magnus, N. Gerges, N. Jabado, and J. Rak Coagulation-related gene expression profile in glioblastoma is defined by molecular disease subtype J Thromb Haemost 11 2013 1197 1200
58. D. Garnier, N. Magnus, T.H. Lee, V. Bentley, B. Meehan, and C. Milsom et al. Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor J Biol Chem 287 2012 43565 43572
59. J.L. Yu, L. May, V. Lhotak, S. Shahrzad, S. Shirasawa, and J.I. Weitz et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis Blood 105 2005 1734 1741 (Pubitemid 40223697)
60. R. Avraham, and Y. Yarden Feedback regulation of EGFR signalling: decision making by early and delayed loops Nat Rev Mol Cell Biol 12 2011 104 117
61. C.C. Milsom, J.L. Yu, N. Mackman, J. Micallef, G.M. Anderson, and A. Guha et al. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis Cancer Res 68 2008 10068 10076
62. Y. Rong, D.E. Post, R.O. Pieper, D.L. Durden, E.G. Van Meir, and D.J. Brat PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma Cancer Res 65 2005 1406 1413 (Pubitemid 40270169)
63. Y. Rong, F. Hu, R. Huang, N. Mackman, J.M. Horowitz, and R.L. Jensen et al. Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms Cancer Res 66 2006 7067 7074 (Pubitemid 44197683)
64. Y. Rong, V.E. Belozerov, C. Tucker-Burden, G. Chen, D.L. Durden, and J.J. Olson et al. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity Cancer Res 69 2009 2540 2549
65. D. Jahner, and T. Hunter The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes Oncogene 6 1991 1259 1268 (Pubitemid 21924216)
66. M. Provencal, N. Berger-Thibault, D. Labbe, R. Veitch, D. Boivin, and G.E. Rivard et al. Tissue factor mediates the HGF/Met-induced anti-apoptotic pathway in DAOY medulloblastoma cells J Neurooncol 97 2010 365 372
67. C. Boccaccio, G. Sabatino, E. Medico, F. Girolami, A. Follenzi, and G. Reato et al. The MET oncogene drives a genetic programme linking cancer to haemostasis Nature 434 2005 396 400 (Pubitemid 40469184)
68. E. D'Asti, A. Huang, and J. Rak Downregulation of tissue factor (TF) in medulloblastoma cells expressing miR-520g Presented at: Keystone Symposia, Snowmass, CO, March 30 2012
69. M.S. Tallman, P. Lefebvre, R.M. Baine, M. Shoji, I. Cohen, and D. Green et al. Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia J Thromb Haemost 2 2004 1341 1350 (Pubitemid 40186131)
70. A. Falanga, M. Marchetti, A. Vignoli, D. Balducci, L. Russo, and V. Guerini et al. V617F JAK-2 mutation in patients with essential thrombocythemia: relation to platelet, granulocyte, and plasma haemostatic and inflammatory molecules Exp Hematol 35 2007 702 711 (Pubitemid 46601748)
71. R.W. Colman, V.J. Marder, and A.W. Clowes Overview of Coagulation, Fibrynolysis, and their Regulation R.B. Coleman, V.J. Marder, A.W. Clowes, J.N. George, S.Z. Goldhaber, Hemostasis and Thrombosis: Basic Principles and Clinical Practice 2006 Lippincott Company Williams & Wilkins Philadelphia 17 20
72. S. Koizume, M.S. Jin, E. Miyagi, F. Hirahara, Y. Nakamura, and J.H. Piao et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII Cancer Res 66 2006 9453 9460 (Pubitemid 44623642)
73. E.B. Schulze, B.D. Hedley, D. Goodale, C.O. Postenka, W. Al-Katib, and A.B. Tuck et al. The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms Breast Cancer Res Treat 112 2008 243 254
74. E. D'Asti, M. Kool, A. Korshunov, A. Huang, S. Pfister, and J. Rak Molecular subtypes define the composition of coagulome in medulloblastoma 2014 Manuscript in preparation
75. J. Rak, J.L. Yu, J. Luyendyk, and N. Mackman Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans Cancer Res 66 2006 10643 10646 (Pubitemid 44876956)
76. D.W. Parsons, S. Jones, X. Zhang, J.C. Lin, R.J. Leary, and P. Angenendt et al. An integrated genomic analysis of human glioblastoma multiforme Science 321 2008 1807 1812
77. M. Kool, A. Korshunov, M. Remke, D.T. Jones, M. Schlanstein, and P.A. Northcott et al. Molecular subgroups of medulloblastoma: An international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas Acta Neuropathol 123 2012 473 484
78. H. Ohgaki, and P. Kleihues Genetic profile of astrocytic and oligodendroglial gliomas Brain Tumor Pathol 28 2011 177 183
79. D. Sturm, H. Witt, V. Hovestadt, D.A. Khuong-Quang, D.T. Jones, and C. Konermann et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma Cancer Cell 22 2012 425 437
80. U. Athale, S. Siciliano, L. Thabane, N. Pai, S. Cox, and A. Lathia et al. Epidemiology and clinical risk factors predisposing to thromboembolism in children with cancer Pediatr Blood Cancer 51 2008 792 797
81. R.J. Gilbertson, and D.W. Ellison The origins of medulloblastoma subtypes Annu Rev Pathol 3 2008 341 365 (Pubitemid 351488285)
82. P.A. Northcott, A. Korshunov, S.M. Pfister, and M.D. Taylor The clinical implications of medulloblastoma subgroups Nat Rev Neurol 8 2012 340 351
83. J. Thaler, C. Ay, N. Mackman, R.M. Bertina, A. Kaider, and C. Marosi et al. Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients J Thromb Haemost 10 2012 1363 1370
84. G.F. Nash Tissue factor (TF) and vascular endothelial growth factor (VEGF) expression in colorectal cancer: relation with cancer recurrence Colorectal Dis 9 2007 858 859 (Pubitemid 47578045)
85. A. Young, O. Chapman, C. Connor, C. Poole, P. Rose, and A.K. Kakkar Thrombosis and cancer Nat Rev Clin Oncol 9 2012 437 449
86. H.R. Buller, F.F. Van Doormaal, G.L. Van Sluis, and P.W. Kamphuisen Cancer and thrombosis: from molecular mechanisms to clinical presentations J Thromb Haemost 5 Suppl 1 2007 246 254 (Pubitemid 46958840)
87. H.H. Versteeg, F. Schaffner, M. Kerver, H.H. Petersen, J. Ahamed, and B. Felding-Habermann et al. Inhibition of tissue factor signaling suppresses tumor growth Blood 111 2008 190 199
88. S. Keshava, H. Kothari, L.V. Rao, and U.R. Pendurthi Influence of endothelial cell protein C receptor on breast cancer development J Thromb Haemost 11 2013 2062 2065
89. A. Amirkhosravi, T. Meyer, M. Amaya, M. Davila, S.A. Mousa, and T. Robson et al. The role of tissue factor pathway inhibitor in tumor growth and metastasis Semin Thromb Hemost 33 2007 643 652 (Pubitemid 350157007)
90. R.A. Auer, A.S. Scheer, J.I. McSparron, A.R. Schulman, S. Tuorto, and S. Doucette et al. Postoperative venous thromboembolism predicts survival in cancer patients Ann Surg 255 2012 963 970
91. A.M. Gil-Bernabe, S. Ferjancic, M. Tlalka, L. Zhao, P.D. Allen, and J.H. Im et al. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice Blood 119 2012 3164 3175
92. L.R. Zacharski Malignancy as a solid-phase coagulopathy: implications for the etiology, pathogenesis, and treatment of cancer Semin Thromb Hemost 29 2003 239 246 (Pubitemid 36776186)
93. J.S. Palumbo, K.E. Talmage, J.V. Massari, C.M. La Jeunesse, M.J. Flick, and K.W. Kombrinck et al. Tumor cell-associated tissue factor and circulating haemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms Blood 110 2007 133 141 (Pubitemid 47026828)
94. C.V. Ngo, K. Picha, F. McCabe, H. Millar, R. Tawadros, and S.H. Tam et al. CNTO 859, a humanized anti-tissue factor monoclonal antibody, is a potent inhibitor of breast cancer metastasis and tumor growth in xenograft models Int J Cancer 120 2007 1261 1267
95. Y. Liu, P. Jiang, K. Capkova, D. Xue, L. Ye, and S.C. Sinha et al. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Cancer Res 71 2011 6492 6502
96. J. Zhao, G. Aguilar, S. Palencia, E. Newton, and A. Abo rNAPc2 inhibits colorectal cancer in mice through tissue factor Clin Cancer Res 15 2009 208 216
97. A.K. Kakkar, M.N. Levine, Z. Kadziola, N.R. Lemoine, V. Low, and H.K. Patel et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) J Clin Oncol 22 2004 1944 1948 (Pubitemid 41095187)
98. A.Y. Lee, F.R. Rickles, J.A. Julian, M. Gent, R.I. Baker, and C. Bowden et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism J Clin Oncol 23 2005 2123 2129 (Pubitemid 46218703)
99. M. Altinbas, H.S. Coskun, O. Er, M. Ozkan, B. Eser, and A. Unal et al. A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer J Thromb Haemost 2 2004 1266 1271 (Pubitemid 40186120)
100. C.P. Klerk, S.M. Smorenburg, H.M. Otten, A.W. Lensing, M.H. Prins, and F. Piovella et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy J Clin Oncol 23 2005 2130 2135 (Pubitemid 46218704)
101. E.A. Akl, S. Gunukula, M. Barba, V.E. Yosuico, F.F. Van Doormaal, and S. Kuipers et al. Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation Cochrane Database Syst Rev 2011 CD006652
102. J. Zhang, Y.L. Zhang, K.X. Ma, and J.M. Qu Efficacy and safety of adjunctive anticoagulation in patients with lung cancer without indication for anticoagulants: A systematic review and meta-analysis Thorax 68 2013 442 450
103. C. Milsom, G.M. Anderson, J.I. Weitz, and J. Rak Elevated tissue factor procoagulant activity in CD133-positive cancer cells J Thromb Haemost 5 2007 2550 2552 (Pubitemid 350154368)
104. S. Karpatkin Does hypercoagulability awaken dormant tumor cells in the host? J Thromb Haemost 2 2004 2103 2106 (Pubitemid 40185768)
105. W.C. Black, and H.G. Welch Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy N Engl J Med 328 1993 1237 1243 (Pubitemid 23115703)
106. J. Liu, Y. Tan, H. Zhang, Y. Zhang, P. Xu, and J. Chen et al. Soft fibrin gels promote selection and growth of tumorigenic cells Nat Mater 11 2012 734 741
107. F. Hochberg, P. Toniolo, and P. Cole Head trauma and seizures as risk factors of glioblastoma Neurology 34 1984 1511 1514 (Pubitemid 14024298)
108. C.Y. Vossen, M. Hoffmeister, J.C. Chang-Claude, F.R. Rosendaal, and H. Brenner Clotting factor gene polymorphisms and colorectal cancer risk J Clin Oncol 29 2011 1722 1727
109. K.A. Steinbrecher, N.A. Horowitz, E.A. Blevins, K.A. Barney, M.A. Shaw, and E. Harmel-Laws et al. Colitis-associated cancer is dependent on the interplay between the haemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen Cancer Res 70 2010 2634 2643
110. P.E. Goss, and A.F. Chambers Does tumor dormancy offer a therapeutic target? Nat Rev Cancer 10 2010 871 877
111. J.A. Aguirre-Ghiso Models, mechanisms and clinical evidence for cancer dormancy Nat Rev Cancer 7 2007 834 846 (Pubitemid 350006258)
112. J.W. Uhr, and K. Pantel Controversies in clinical cancer dormancy Proc Natl Acad Sci U S A 108 2011 12396 12400
113. N. Magnus, D. Garnier, B. Meehan, M. Hashemi, T.-H. Lee, and C.C. Milsom et al. Procoagulant receptor tissue factor provokes the escape from brain tumor dormancy Proc Am Assoc Cancer Res 2013 (in-press)
114. J.I. Weitz Potential of new anticoagulants in patients with cancer Thromb Res 125 Suppl 2 2010 S30 S35