Endothelium - Role in regulation of coagulation and inflammation

Seminars in Immunopathology

Volumn 34, Issue 1, 2012, Pages 93-106

  Van Hinsbergh, Victor W M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Activated protein C; ADAMTS13; Antithrombotic; Endothelial cell; Fibrinolysis; Inflammation; Von willebrand factor

Indexed keywords

ANTITHROMBIN III; ENDOTHELIAL PROTEIN C RECEPTOR; METALLOPROTEINASE; NITRIC OXIDE; PROSTACYCLIN; PROTEIN ADAMTS18; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBOMODULIN; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; PLASMA PROTEIN; VASOCONSTRICTOR AGENT;

ANGIOGENESIS; ANTICOAGULATION; ATHEROSCLEROTIC PLAQUE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CELL FUNCTION; CELL INTERACTION; ENDOTHELIUM CELL; FIBRINOLYSIS; HEMOSTASIS; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; IN VIVO STUDY; INFLAMMATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SEPSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; TISSUE REPAIR; VASODILATATION; ANIMAL; BLOOD; IMMUNOLOGY; LEUKOCYTE; METABOLISM; THROMBOCYTE; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD PLATELETS; BLOOD PROTEINS; ENDOTHELIUM, VASCULAR; FIBRINOLYSIS; HUMANS; INFLAMMATION; LEUKOCYTES; PLATELET AGGREGATION; RECEPTOR, PAR-1; VASOCONSTRICTOR AGENTS;

EID: 84857766493     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-011-0285-5     Document Type: Review

References (130)

1. Gimbrone MA et al (1986) Vascular endothelium: nature's blood container. In: Vascular endothelium in hemostasis and thrombosis. Churchill Livingstone, New York, pp 1-13
2. Wolinsky H (1980) A proposal linking clearance of circulating lipoproteins to tissue metabolic-activity as a basis for understanding atherogenesis. Circ Res 47:301-311
3. Aird WC (2007) Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms. Circ Res 100:158-173
4. Mehta D, Malik AB (2006) Signaling mechanisms regulating endothelial permeability. Physiol Rev 86:279-367
5. Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7:803-815 (Pubitemid 47480307)
6. Semenza GL (2010) Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol 30:648-652
7. Bakker W, Eringa EC, Sipkema P, van Hinsbergh VWM (2009) Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. Cell Tissue Res 335:165-189
8. Fraisl P, Mazzone M, Schmidt T, Carmeliet P (2009) Regulation of angiogenesis by oxygen and metabolism. Dev Cell 16:167-179
9. Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MAJ, Balasubramanian V, Garcia-Cardena G, Jain MK (2005) Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res 96:e48-e57
10. Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJM, Biessen EAL, van Berkel TJC, Pannekoek H, Horrevoets AJG (2005) Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol 167:609-618 (Pubitemid 43026114)
11. Parmar KM, Larman HB, Dai GH, Zhang YH, Wang ET, Moorthy SN, Kratz JR, Lin ZY, Jain MK, Gimbrone MA, Garcia-Cardena G (2006) Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Investig 116:49-58 (Pubitemid 43121790)
12. Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, Van de Rijn M, Botstein D, Brown PO (2003) Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A 100:10623-10628 (Pubitemid 37140079)
13. Defilippi P, Vanhinsbergh V, Bertolotto A, Rossino P, Silengo L, Tarone G (1991) Differential distribution and modulation of expression of alpha1/beta1 integrin on human endothelial-cells. J Cell Biol 114:855-863 (Pubitemid 21909851)
14. Keuschnigg J, Henttinen T, Auvinen K, Karikoski M, Salmi M, Jalkanen S (2009) The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. Blood 114:478-484
15. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC (1993) Alpha-4-Beta-7-integrin mediates lymphocyte binding to the mucosal vascular addressin Madcam-1. Cell 74:185-195 (Pubitemid 23219889)
16. Laszik Z, Mitro A, Taylor FB, Ferrell G, Esmon CT (1997) Human protein C receptor is present primarily on endothelium of large blood vessels - Implications for the control of the protein C pathway. Circulation 96:3633-3640 (Pubitemid 27513443)
17. Aird WC (2007) Phenotypic heterogeneity of the endothelium II. Representative vascular beds. Circ Res 100:174-190
18. vanSetten PA, vanHinsbergh VWM, vanderVelden TJAN, vandeKar NCAJ, Vermeer M, Mahan JD, Assmann KJM, vandenHeuvel LPWJ, Monnens LAH (1997) Effects of TNF alpha on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells. Kidney Int 51:1245-1256
19. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, Mcever RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, Mccrae KR, Hug BA, Schmidt AM, Stern DM (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91:3527-3561 (Pubitemid 28225719)
20. Semenza GL (2009) Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology 24:97-106
21. Wouters BG, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Canc 8:851-864
22. Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The I kappa B-NF-kappa B signaling module: temporal control and selective gene activation. Science 298:1241-1245 (Pubitemid 35285493)
23. Faure E, Thomas L, Xu H, Medvedev AE, Equils O, Arditi M (2001) Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol 166:2018-2024 (Pubitemid 32114690)
24. Hansson GK (2009) Inflammatory mechanisms in atherosclerosis. J Thromb Haemost 7:328-331
25. Bista P, Zeng WK, Ryan S, Bailly V, Browning JL, Lukashev ME (2010) TRAF3 controls activation of the canonical and alternative NF kappa B by the lymphotoxin beta receptor. J Biol Chem 285:12971-12978
26. Qian HS, Neplioueva V, Shetty CA, Channon KM, George SE (1999) Nitric oxide synthase gene therapy rapidly reduces adhesion molecule expression and inflammatory cell infiltration in carotid arteries of cholesterol-fed rabbits. Circulation 99:2979-2982 (Pubitemid 29270425)
27. Sen-Banerjee S, Mir S, Lin ZY, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A, Jain MK (2005) KLF2 as a novel mediator of statin effects in endothelial cells. Circulation 112:720-726 (Pubitemid 41099052)
28. Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermohlen O, Bruning JC, Schutze S, Kronke M (2009) Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 460:1159-1163
29. Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT (2000) Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 95:1687-1693 (Pubitemid 30120830)
30. Wu HL, Lin CI, Huang YL, Chen PS, Kuo CH, Chen MS, Wu GCC, Shi GY, Yang HY, Lee H (2008) Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells. Biochem Biophys Res Commun 367:162-168
31. Dignat-George F, Boulanger CM (2011) The many faces of endothelial microparticles. Arterioscler Thromb Vasc Biol 31:27-33
32. Nieuwdorp M, van Haeften TW, Gouverneur MCLG, Mooij HL, van Lieshout MHP, Levi M, Meijers JCM, Holleman F, Hoekstra JBL, Vink H, Kastelein JJP, Stroes ESG (2006) Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes 55:480-486 (Pubitemid 43343279)
33. Vlodavsky I, Eldor A, Haimovitzfriedman A, Matzner Y, Ishaimichaeli R, Lider O, Naparstek Y, Cohen IR, Fuks Z(1992) Expression of heparanase by platelets and circulating cells of the immune-system - possible involvement in diapedesis and extravasation. Invasion Metastasis 12:112-127
34. Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, Vanhinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A (1997) Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315-325 (Pubitemid 27148598)
35. Sharfuddin AA, Sandoval RM, Berg DT, McDougal GE, Campos SB, Phillips CL, Jones BE, Gupta A, Grinnell BW, Molitoris BA (2009) Soluble thrombomodulin protects ischemic kidneys. J Am Soc Nephrol 20:524-534
36. Danese S, Dejana E, Fiocchi C (2007) Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 178:6017-6022 (Pubitemid 46717378)
37. Aird WC (2007) Vascular bed-specific thrombosis. J Thromb Haemost 5:283-291
38. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B (2002) Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 8:1175-1180 (Pubitemid 35175975)
39. Mackman N (2009) The many faces of tissue factor. J Thromb Haemost 7:136-139
40. Osterud B, Bajaj MS, Bajaj SP (1995) Sites of tissue factor pathway inhibitor (Tfpi) and tissue factor expression under physiological and pathological conditions. Thromb Haemost 73:873-875
41. White TA, Johnson T, Zarzhevsky N, Tom C, Delacroix S, Holroyd EW, Maroney SA, Singh R, Pan SC, Fay WP, van Deursen J, Mast AE, Sandhu GS, Simari RD (2010) Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116:1787-1794
42. Drake TA, Morrissey JH, Edgington TS (1989) Selective cellular expression of tissue factor in human-tissues - implications for disorders of hemostasis and thrombosis. Am J Pathol 134:1087-1097 (Pubitemid 19142892)
43. Mackman N, Tilley RE, Key NS (2007) Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 27:1687-1693 (Pubitemid 47207163)
44. Colucci M, Balconi G, Lorenzet R, Pietra A, Locati D, Donati MB, Semeraro N (1983) Cultured human-endothelial cells generate tissue factor in response to endotoxin. J Clin Investig 71:1893-1896 (Pubitemid 13056793)
45. Lupu C, Westmuckett AD, Peer G, Ivanciu L, Zhu H, Taylor FB, Lupu F (2005) Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsis. Am J Pathol 167:1161-1172 (Pubitemid 41416266)
46. Contrino J, Hair G, Kreutzer DL, Rickles FR (1996) In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 2:209-215 (Pubitemid 26054985)
47. Ryan J, Brett J, Tijburg P, Bach RR, Kisiel W, Stern D (1992) Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix vesicles but is not expressed on the apical surface. Blood 80:966-974
48. Combes V, Simon AC, Grau GE, Arnoux D, Camoin L, Sabatier F, Mutin M, Sanmarco M, Sampol J, gnat-George F (1999) In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Investig 104:93-102 (Pubitemid 29534349)
49. Tushuizen ME, Diamant M, Sturk A, Nieuwland R (2011) Cell-derived microparticles in the pathogenesis of cardiovascular disease friend or foe? Arterioscler Thromb Vasc Biol 31:4-9
50. Egorina EM, Sovershaev MA, Olsen JO, Osterud B (2008) Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer. Blood 111:1208-1216 (Pubitemid 351213402)
51. Solovey A, Kollander R, Milbauer LC, Abdulla F, Chen YIE, Kelm RJ, Hebbel RP (2010) Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse. Am J Hematol 85:41-45
52. Jasuja R, Furie B, Furie BC (2010) Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo. Blood 116:4665-4674
53. Bauer KA, Rosenberg RD (1991) Role of antithrombin-iii as a regulator of invivo coagulation. Semin Hematol 28:10-18
54. Ishii H, Salem HH, Bell CE, Laposata EA, Majerus PW (1986) Thrombomodulin, an endothelial anticoagulant protein, is absent from the human-brain. Blood 67:362-365 (Pubitemid 16164649)
55. Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, Del-Favero J, Plaisance S, Claes B, Lambrechts D, Zoja C, Remuzzi G, Conway EM (2009) Thrombomodulin mutations in atypical hemolytic-uremic syndrome. New Engl JMed 361:345-357
56. Bajzar L, Morser J, Nesheim M (1996) TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem 271:16603-16608 (Pubitemid 26239017)
57. Van de Wouwer M, Plaisance S, De Vriese A, Waelkens E, Collen D, Persson J, Daha MR, Conway EM (2006) The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis. J Thromb Haemost 4:1813-1824 (Pubitemid 44144810)
58. Fukudome K, Kurosawa S, StearnsKurosawa DJ, He XH, Rezaie AR, Esmon CT (1996) The endothelial cell protein C receptor - cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 271:17491-17498 (Pubitemid 26244316)
59. Bae JS, Yang LK, Rezaie AR (2007) Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A 104:2867-2872
60. Russo A, Soh UJK, Paing MM, Arora P, Trejo J (2009) Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A 106:6393-6397
61. Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, Pendurthi UR, Rao LVM (2011) Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 117:3199-3208
62. Feistritzer C, Riewald M (2005) Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105:3178-3184
63. Niessen F, Furlan-Freguia C, Fernandez JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W (2009) Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood 113:2859-2866 (Retracted Blood (2011) 117: 7188)
64. Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, ndrade-Gordon P, Rosen H, Ruf W (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452:654-658 (Pubitemid 351483355)
65. Singleton PA, Moreno-Vinasco L, Sammani S, Wanderling SL, Moss J, Garcia JGN (2007) Attenuation of vascular permeability by methylnaltrexone - role of mOP-R and S1P3 transactivation. Am J Respir Cell and Mol Biol 37:222-231 (Pubitemid 47255005)
66. Bae JS, Rezaie AR (2009) Thrombin inhibits nuclear factor kappa B and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost 101:513-520
67. Van Sluis GL, Niers TMH, Esmon CT, Tigchelaar W, Richel DJ, Buller HR, Van Noorden CJF, Spek CA (2009) Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood 114:1968-1973
68. Garcia JGN, Liu F, Verin AD, Birukova A, Dechert MA, Gerthoffer WT, Bamburg JR, English D (2001) Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Investig 108:689-701 (Pubitemid 32906197)
69. Cao CZ, Gao YM, Li Y, Antalis TM, Castellino FJ, Zhang L (2010) The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Investig 120:1971-1980
70. Kerschen E, Hernandez I, Zogg M, Jia SA, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H (2010) Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Investig 120:3167-3178
71. Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S (2007) Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J Clin Investig 117:1951-1960 (Pubitemid 47036329)
72. Ye XB, Ding JQ, Zhou XZ, Chen GQ, Liu SF (2008) Divergent roles of endothelial NF-kappa B in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med 205:1303-1315
73. Song DM, Ye XB, Xu HL, Liu SF (2009) Activation of endothelial intrinsic NF-kappa B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood 114:2521-2529
74. Guitton C, Cottereau A, Gerard N, Quillard T, Chauveau A, Devalliere J, Tonnerre P, Charreau B (2011) Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-kappa B, and ERK1/2 MAP kinases. Am J Physiol Cell Physiol 300:C833-C842
75. O'Brien LA, Richardson MA, Mehrbod SF, Berg DT, Gerlitz B, Gupta A, Grinnell BW (2007) Activated protein c decreases tumor necrosis factor-related apoptosis-inducing ligand by an EPCR-Independent mechanism involving Egr-1/Erk-1/2 activation. Arterioscler Thromb Vasc Biol 27:2634-2641 (Pubitemid 350158916)
76. Berriman JA, Li S, Hewlett LJ, Wasilewski S, Kiskin FN, Carter T, Hannah MJ, Rosenthal PB (2009) Structural organization of Weibel - Palade bodies revealed by cryo-EM of vitrified endothelial cells. Proc Natl Aca Sci U S A 106:17407-17412
77. Sadler JE (2009) von Willebrand factor assembly and secretion. J Thromb Haemost 7:24-27
78. Giblin JP, Hewlett LJ, Hannah MJ (2008) Basal secretion of von Willebrand factor from human endothelial cells. Blood 112:957-964
79. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG (2004) The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103:4150-4156 (Pubitemid 38685356)
80. Bae JS, Rezaie AR (2010) Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost 8:1107-1115
81. Valentijn KM, van Driel LF, Mourik MJ, Hendriks GJ, Arends TJ, Koster AJ, Valentijn JA (2010) Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells. Blood 116:1807-1816
82. Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, Eikenboom J (2011) Functional architecture of Weibel-Palade bodies. Blood 117(19):5033-5043
83. Cleator JH, Zhu WQ, Vaughan DE, Hamm HE (2006) Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. Blood 107:2736-2744
84. Turner NA, Nolasco L, Ruggeri ZM, Moake JL (2009) Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood 114:5102-5111
85. Shim K, Anderson PJ, Tuley EA, Wiswall E, Sadler JE (2008) Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. Blood 111:651-657
86. Majerus EM, Zheng XL, Tuley EA, Sadler JE (2003) Cleavage of the ADAMTS13 propeptide is not required for protease activity. J Biol Chem 278:46643-46648 (Pubitemid 37452240)
87. Vomund AN, Majerus EM (2009) ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor. J Biol Chem 284:30925-30932
88. Davis AK, Makar RS, Stowell CP, Kuter DJ, Dzik WH (2009) ADAMTS13 binds to CD36: a potential mechanism for platelet and endothelial localization of ADAMTS13. Transfusion 49:206-213
89. Bonnefoy A, Daenens K, Feys HB, De Vos R, Vandervoort P, Vermylen J, Lawler J, Hoylaerts MF (2006) Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Blood 107:955-964 (Pubitemid 43156292)
90. Rock G, Clark W, Sternbach M, Kolajova M, McLaine P (2005) Haemolytic uraemic syndrome is an immune-mediated disease: role of anti-CD36 antibodies. Br J Haematol 131:247-252 (Pubitemid 43899693)
91. Claus RA, Bockmeyer CL, Sossdorf M, Losche W (2010) The balance between von-Willebrand factor and its cleaving protease ADAMTS13: biomarker in systemic inflammation and development of organ failure? Curr Mol Med 10:236-248
92. Manea M, Karpman D (2009) Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura. Pediatr Nephrol 24:447-458
93. Reiter RA, Varadi K, Turecek PL, Jilma B, Knobl P (2005) Changes in ADAMTS13 (von-Willebrand-factor-cleaving protease) activity after induced release of von Willebrand factor during acute systemic inflammation. Thromb Haemost 93:554-558 (Pubitemid 40392546)
94. Cao WJ, Niiya M, Zheng XW, Shang DZ, Zheng XL (2008) Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. J Thromb Haemost 6:1233-1235 (Pubitemid 351859136)
95. Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD (2008) ADAMTS13: a new link between thrombosis and inflammation. J Exp Med 205:2065-2074
96. Motto DG, Chauhan AK, Zhu GJ, Homeister J, Lamb CB, Desch KC, Tsai HM, Wagner DD, Ginsburg D (2005) Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. Blood 106:723
97. Huang J, Motto DG, Bundle DR, Sadler JE (2010) Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. Blood 116:3653-3659
98. Feys HB, Roodt J, Vandeputte N, Pareyn I, Lamprecht S, van Rensburg WJ, Anderson PJ, Budde U, Louw VJ, Badenhorst PN, Deckmyn H, Vanhoorelbeke K (2010) Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus). Blood 116:2005-2010
99. Sixma JJ, vanZanten GH, Huizinga EG, vanderPlas RM, Verkley M, Wu YP, Gros P, deGroot PG (1997) Platelet adhesion to collagen: an update. Thromb Haemost 78:434-438
100. Pearson JD (1999) Endothelial cell function and thrombosis. Best Pract Res Clin Haematol 12:329-341
101. Gerritsen ME (1987) Functional-heterogeneity of vascular endothelial-cells - commentary. Biochem Pharmacol 36:2701-2711
102. Fulton D, Gratton JP, Mccabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
103. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
104. Ramesh S, Morrell CN, Tarango C, Thomas GD, Yuhanna IS, Girardi G, Herz J, Urbanus RT, de Groot PG, Thorpe PE, Salmon JE, Shaul PW, Mineo C (2011) Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via beta 2GPI and apoER2. J Clin Investig 121:120-131
105. Li Z, Nardi MA, Li YS, Zhang W, Pan RM, Dang SY, Yee H, Quartermain D, Jonas S, Karpatkin S (2009) C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke. Blood 113:6051-6060
106. Medcalf RL (2007) Fibrinolysis, inflammation, and regulation of the plasminogen activating system. J Thromb Haemost 5:132-142
107. Emeis JJ, vandenEijndenSchrauwen Y, vandenHoogen CM, dePriester W, Westmuckett A, Lupu F (1997) An endothelial storage granule for tissue-type plasminogen activator. J Cell Biol 139:245-256
108. Huber D, Cramer EM, Kaufmann JE, Meda P, Masse JM, Kruithof EKO, Vischer UM (2002) Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. Blood 99:3637-3645 (Pubitemid 34534533)
109. Hiraoka N, Allen E, Apel IJ, Gyetko MR, Weiss SJ (1998) Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95:365-377 (Pubitemid 28507325)
110. vanHinsbergh VWM, Vandenberg EA, Fiers W, Dooijewaard G (1990) Tumor-necrosis-factor induces the production of urokinase-type plasminogen-activator by human endothelial-cells. Blood 75:1991-1998 (Pubitemid 20180288)
111. Blasi F, Sidenius N (2010) The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett 584:1923-1930
112. Stratman AN, Saunders WB, Sacharidou A, Koh W, Fisher KE, Zawieja DC, Davis MJ, Davis GE (2009) Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Blood 114:237-247
113. Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, Stockinger H, Binder BR (2004) Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor. Circ Res 94:1562-1570 (Pubitemid 38856963)
114. van Hinsbergh VWM, Engelse MA, Quax PHA (2006) Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler Thromb Vasc Biol 26:716-728 (Pubitemid 43732143)
115. Connolly BM, Choi EY, Gardsvoll H, Bey AL, Currie BM, Chavakis T, Liu SH, Molinolo A, Ploug M, Leppla SH, Bugge TH (2010) Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood 116:1593-1603
116. Sawdey MS, Loskutoff DJ (1991) Regulation of murine type-1 plasminogen-activator inhibitor gene-expression invivo - tissue-specificity and induction by lipopolysaccharide, tumor-necrosis-factor-alpha, and transforming growth-factor-beta. J Clin Investig 88:1346-1353
117. vanHinsbergh VWM, Kooistra T, Vandenberg EA, Princen HMG, Fiers W, Emeis JJ (1988) Tumor necrosis factor increases the production of plasminogen- activator inhibitor in human-endothelial cells-invitro and in rats invivo. Blood 72:1467-1473 (Pubitemid 18268620)
118. vanHinsbergh VWM, Bertina RM, Vanwijngaarden A, Vantilburg NH, Emeis JJ, Haverkate F (1985) Activated protein-C decreases plasminogen-activator inhibitor activity in endothelial cell-conditioned medium. Blood 65:444-451 (Pubitemid 15163584)
119. Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ (1985) Activated protein-C stimulates the fibrinolytic-activity of cultured endothelial-cells and decreases anti-activator activity. Proc Natl Acad Sci U S A 82:1121-1125 (Pubitemid 15100506)
120. van Hinsbergh VWM, Collen A, Koolwijk P (2001) Role of fibrin matrix in angiogenesis. In: Nieuwenhuizen W, Mosesson MW, DeMaat MPM (eds). Ann N Y Acad Sci 936:426-437.
121. Shaikh FM, Callanan A, Kavanagh EG, Burke PE, Grace PA, McGloughlin TM (2008) Fibrin: a natural biodegradable scaffold in vascular tissue engineering. Cells Tissues Organs 188:333-346
122. Ribes JA, Ni F, Wagner DD, Francis CW (1989)Mediation of fibrin-induced release of von Willebrand-factor from cultured endothelial-cells by the fibrin beta-chain. J Clin Investig 84:435-442 (Pubitemid 19196973)
123. Guo YH, Hernandez I, Isermann B, Kang TB, Medved L, Sood R, Kerschen EJ, Holyst T, Mosesson MW, Weiler H (2009) Caveolin-1-dependent apoptosis induced by fibrin degradation products. Blood 113:4431-4439
124. Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K (2005) The fibrin-derived peptide B beta(15-42) protects the myocardium against ischemia-reperfusion injury. Nat Med 11:298-304 (Pubitemid 40460558)
125. Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, Kasprzak JD, Butter C, Grip L, Hansen PR, Suselbeck T, Clemmensen PM, Marin-Galiano M, Geudelin B, Buser PT (2009) Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the FIRE (Efficacy of FX06 in the prevention of myocardial reperfusion injury) trial. J Am Coll Cardiol 53:720-729
126. Wijelath ES, Murray J, Rahman S, Patel Y, Ishida A, Strand K, Aziz S, Cardona C, Hammond WP, Savidge GF, Rafii S, Sobel M (2002) Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity. Circ Res 91:25-31 (Pubitemid 34778938)
127. Italiano JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111:1227-1233 (Pubitemid 351213404)
128. van Gils JM, Zwaginga JJ, Hordijk PL (2009) Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 85:195-204
129. Semple JW, Italiano JE, Freedman J (2011) Platelets and the immune continuum. Nat Rev Immunol 11:264-274
130. Lutgens E, Gorelik L, Daemen MJAP, de Muinck E, Grewal IS, Koteliansky VE, Flavell RA (1999) Requirement for CD154 in the progression of atherosclerosis. Nat Med 5:1313-1316 (Pubitemid 29535611)