The MET oncogene drives a genetic programme linking cancer to haemostasis

Nature

Volumn 434, Issue 7031, 2005, Pages 396-400

  Boccaccio, Carla ^a   Sabatino, Gabriella ^a   Medico, Enzo ^a   Girolami, Flavia ^a   Follenzi, Antonia ^a   Reato, Gigliola ^a   Sottile, Antonino ^a   Naldini, Luigi ^a   Comoglio, Paolo M ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; COAGULATION; EPIDEMIOLOGY; LIVING SYSTEMS STUDIES; PATHOLOGY; TUMORS;

HAEMOSTASIS; HYPERCOAGULATION; ONCOGENES; SOMATIC CELLS;

GENES;

CYCLOOXYGENASE 2; PLASMINOGEN ACTIVATOR INHIBITOR 1; GROWTH FACTOR RECEPTOR; MEMBRANE PROTEIN; MET PROTEIN, HUMAN; ONCOPROTEIN; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN;

GENETICS;

ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENETIC MANIPULATION; GENETIC TRANSCRIPTION; HEMOSTASIS; IN VIVO STUDY; LIVER CARCINOGENESIS; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE MET; PHENOMENOLOGY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; SOMATIC CELL; THROMBOPHLEBITIS; UPREGULATION; ANIMAL; CELL TRANSFORMATION; DIMERIZATION; GENETICS; HEMATOLOGIC DISEASE; HUMAN; LIVER CELL; LIVER TUMOR; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BLOOD COAGULATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLOOXYGENASE 2; DIMERIZATION; HEMATOLOGIC DISEASES; HEMOSTASIS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MEMBRANE PROTEINS; MICE; MICE, SCID; ONCOGENES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 15244345941     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03357     Document Type: Article

References (30)

1. Trousseau, A. Phlegmasia alba dolens. Clinique Médicale de l'Hotel-Dieu de Paris Vol 3, 654-712 (J. B. Ballière et Fils, Paris, 1865).
2. Baron, J. A., Gridley, G., Weiderpass, E., Nyrén, O. & Linet, M. Venous thromboembolism and cancer. Lancet 351, 1077-1080 (1998).
3. Rickles, F. R. & Levine, M. N. Epidemiology of thrombosis in cancer. Acta Haematol. 106, 6-12 (2001).
4. Lee, A. Y. Y. & Levine, M. N. Venous thromboembolism and cancer: risks and outcomes. Circulation 107 (suppl.), I17-I21 (2003).
5. Vigna, E. & Naldini, L. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J. Gene Med. 2, 308-316 (2000).
6. Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Rev. Cancer 2, 289-300 (2002).
7. Schmidt, L. et al. Germline and somatic mutations in the tyrosine kinase domain of the MET protooncogene in papillary renal carcinomas. Nature Genet. 16, 68-73 (1997).
8. Di Renzo, M. F. et al. Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene 6, 1997-2003 (1991).
9. Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-361 (2003).
10. Park, M. et al. Mechanism of met oncogene activation. Cell 45, 895-904 (1986).
11. Dull, T. et al. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72, 8463-8471 (1998).
12. Follenzi, A., Sabatino, G., Lombardo, A., Boccaccio, C. & Naldini, L. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum. Gene Ther. 13, 243-260 (2002).
13. Ponder, K. P. et al. Mouse hepatocytes migrate to Liver parenchyma and function indefinitely after intrasplenic transplantation. Proc. Natl Acad. Sci. USA 88, 1217-1221 (1991).
14. Pfeifer, A. et al. Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol. Ther. 3, 319-322 (2001).
15. Rickles, F. R., Levine, M. N. & Dvorak, H. B. in Hemostasis and Thrombosis (eds Colman, R. W., Hirsh, J., Marder, V. J., Clowes, A. & George, J. N.) 1132-1152 (Lippincott Williams & Wilkins, Philadelphia, 2000).
16. Muller-Berghaus, G., ten Cate, H. & Levi, M. Disseminated intravascular coagulation: clinical spectrum and established as well as new diagnostic approaches. Thromb. Haemost. 82, 706-712 (1999).
17. Collen, D. The plasminogen (fibrinolytic) system. Thromb. Haemost. 82, 259-270 (1999).
18. Smith, W. L., De Witt, D. L. & Garavito, R. M. Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem. 69, 145-182 (2000).
19. Friederich, P. W. et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation 96, 916-921 (1997).
20. Gupta, R. A. & DuBois, R. N. Colorectal cancer prevention and treatment by inhibition of cylooxygenase-2. Nature Rev. Cancer 1, 13-20 (2001).
21. Dvorak, H. F. Tumors: wounds that do not heal. N. Engl. J. Med. 315, 1650-1659 (1986).
22. Zeng, Q., McCauley, L. K. & Wang, C. Y. Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. J. Biol. Chem. 277, 50137-50142 (2002).
23. FitzGerald, G. A. COX-2 and beyond: Approaches to prostaglandin inhibition in human disease. Nature Rev. Drug Discov. 2, 879-890 (2003).
24. Sidenius, N. & Blasi, F. The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev. 22, 205-222 (2003).
25. Nakamura, T. et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 342, 440-443 (1989).
26. Trusolino, L., Pugliese, L. & Comoglio, P. M. Interactions between scatter factors and their receptors: hints for therapeutic applications. FASEB J. 12, 1267-1280 (1998).
27. Follenzi, A., Ailles, L. E., Bakovic, S., Geuna, M. & Naldini, L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nature Genet. 25, 217-222 (2000).
28. Medico, E. et al. The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol. Biol. Cell 7, 495-504 (1996).
29. Li, C. & Wong, W. H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl Acad. Sci. USA 98, 31-36 (2001).
30. Oshima, M. et al. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61, 1733-1740 (2001).