The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells

Thrombosis and Haemostasis

Volumn 92, Issue 1, 2004, Pages 13-22

  Wiiger, Merete Thune ^a   Prydz, Hans ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

EGFR; IL 8; Proline rich tyrosine kinase 2; SHP 2; Yes

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CYTOKINE RECEPTOR; EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; FOCAL ADHESION KINASE 2; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEINASE ACTIVATED RECEPTOR 2; THROMBOPLASTIN; TYROSINE;

ARTICLE; AUTOPHOSPHORYLATION; BLOOD CLOTTING; CELL LINE; CELL MEMBRANE; CELL SURFACE; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 3543009588     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th03-08-0549     Document Type: Article

References (46)

1. Bazan JF. Haemopoietic receptors and helical cytokines. Immunol Today 1990; 11: 350-4.
2. 2+ signals in J82 cells, transfected COS-1 cells, MDCK cells and in human endothelial cells induced to synthesise tissue factor. J Biol Chem 1995; 270: 4650-60.
3. Camerer E, Røttingen J-A, Gjernes E, et al. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem 1999; 274: 32225-33.
4. Carmeliet P, Mackman N, Moons L, et al. Role of tissue factor in embryoic blood vessel development. Nature 1996; 383: 73-5.
5. Erlich J, Parry G, Fearns C, et al. Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. Proc Natl Acad Sci 1999; 96: 8138-43.
6. Chen J, Bierhaus A, Schiekofer S, et al. Tissue Factor - A receptor involved in the control of cellular properties including angiogenesis. Thromb Haemost 2001; 86: 334-45.
7. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 1996; 271: 29034-42.
8. Poulsen LK, Jacobsen N, Sørensen BB, et al. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor. J Biol Chem 1998; 273: 6228-32.
9. Versteeg HH, Hoedemaeker I, Diks SH, et al. Factor VIIa/Tissue Factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac. J Biol Chem 2000; 275: 28750-6.
10. Versteeg HH, Sorensen BB, Slofstra SH, et al. VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation. J Biol Chem 2002; 277: 27065-72.
11. Camerer E, Gjernes E, Wiiger M, et al. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression. J Biol Chem 2000; 275: 6580-5.
12. Martin P. Wound healing - aiming for perfect skin regeneration. Science 1997; 276: 75-81.
13. Pendurthi UR, Allen KE, Ezban M, et al. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa Tissue Factor-induced signal transduction. J Biol Chem 2000; 275: 14632-41.
14. Pendurthi UR, Alok D, Rao LVM. Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up- regulation of poly (A) polymerase. Proc Natl Acad Sci 1997; 94: 12598-603.
15. Taniguchi T, Kakkar AK, Tuddenham EGD, et al. Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer. Cancer Res 1998; 58: 4461-7.
16. Wang X, Gjernes E, Prydz H. Factor VIIa induces tissue factor-dependent up-regulation of interleukin-8 in a human keratinocyte line. J Biol Chem 2002; 277: 23620-6.
17. Camerer E, Huang W, Coughlin SR. Tissue factor and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci 2000; 97: 5255-60.
18. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci 2001; 98: 7742-7.
19. Gutkind JS. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998; 273: 1839-42.
20. Kholodenko BN. MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience. Trends Cell Biol 2002; 12: 173-7.
21. Daub H, Weiss FU, Wallasch C, et al. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996; 379: 557-60.
22. 2+-induced regulation of ion channel and MAP kinase functions. Nature 1995; 376: 737-45.
23. Yu H, Li X, Marchetto GS, et al. Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J Biol Chem 1996; 271: 29993-8.
24. Li X, Dy RC, Cance WG, et al. Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion kinase. J Biol Chem 1999; 274: 8917-24.
25. Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol 1999; 146: 697-702.
26. Tice DA, Biscardi JS, Nickles AL, et al. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci 1999; 96: 1415-20.
27. Bishayee A, Beguinot L, Bishayee S. Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor C-terminal tail. Mol Biol Cell 1999; 10: 525-36.
28. Traxler P, Bold G, Frei J, et al. Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: 4-(Phenylamino) pyrazolo[3,4-d]pyrimidines. J Med Chem 1997; 40: 3601-16.
29. Tokiwa G, Dikic I, Lev S, et al. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 1996; 273: 792-4.
30. Dikic I, Tokiwa G, Lev S, et al. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996; 383: 547-50.
31. Avraham H, Park S-H, Schinkmann K et al. RAFTK/Pyk2-mediated cellular signalling. Cell Signal 2000; 12: 123-33.
32. Tang H, Zhao ZJ, Landon EW, et al. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. J Biol Chem 2000; 275: 8389-96.
33. Yu Z, Ahmad S, Schwartz J-L, et al. Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. J Biol Chem 1997; 272: 7519-24.
34. Hanke JH, Gardner JP, Dow RL, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J Biol Chem 1996; 271: 695-701.
35. Blaukat A, Ivankovic-Dikic I, Gronroos E, et al. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Cell Biol 1999; 274: 14893-901.
36. Bogdan S, Klämbt C. Epidermal growth factor receptor signaling. Curr Biol 2001; 10: R292-R295.
37. Andreev J, Galisteo ML, Kranenburg O, et al. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 2001; 276: 20130-5.
38. Lakkakorpi PT, Bett AJ, Lipfert L, et al. PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-src, osteoclast spreading, and bone resorption. J Biol Chem 2003; 278: 11502-12.
39. Sancho D, Montoya MC, Monjas A, et al. TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T Cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion. J Immunol 2002; 169: 292.
40. MacFarlane SR, Seatter MJ, Kanke T, et al. Proteinase-activated receptors. Pharmaocol Rev 2001; 53: 245-82.
41. Thomas SM, Brugge JS. Cellular functions regulated by src family kinases. Annu Rev Cell Dev Biol 1997; 13: 513-609.
42. Ma YC, Huang J, Ali S, et al. Src tyrosine kinase is a novel direct effector of G proteins. Cell 2000; 102: 635-46.
43. Hur E-M, Kim K-T. G protein-coupled receptor signalling and cross-talk Achieving rapidity and specificity. Cell Signal 2002; 14: 397-405.
44. Daub H, Wallasch C, Lankenau A, et al. Signal characteristics of G protein-transactivated EGF receptor. EMBO J 1997; 16: 7032-44.
45. Prenzel N, Zwick E, Daub H, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-8.
46. Kalmes A, Vesti BR, Daum G, et al. Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor. Circ Res 2000; 87: 92-8.