In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

Nature Medicine

Volumn 2, Issue 2, 1996, Pages 209-215

  Contrino, Josephine ^a   Hair, Gregory ^a,b,c   Kreutzer, Donald L ^a   Rickles, Frederick R ^a,c,d,e  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; THROMBOPLASTIN;

ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST TUMOR; CLINICAL ARTICLE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; TUMOR VASCULARIZATION;

BREAST NEOPLASMS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; THROMBOPLASTIN;

EID: 0030020590     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0296-209     Document Type: Article

References (12)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27-31 (1995).
2. Weidner, N. et al. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84, 1875-1887 (1992).
3. Van Hoef, M.E.H.M., Knox, W.F., Dhesi, S.S., Howell, A. & Schor, A.M. Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer. Eur. J. Cancer 29A, 1141-1145 (1993).
4. Gasparini, G. et al. Tumor microvessel density, p53 expression, tumor size and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J. clin. Oncol. 12, 454-466 (1994).
5. Folkman, J. Angiogenesis and breast cancer. J. clin. Oncol. 12, 441-443 (1994).
6. Weidner, N, Carroll, P.R., Flax, J., Blumenfeld, W. & Folkman, J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143, 401-409 (1993).
7. Li, V.W. et al. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumors. Lancet 344, 82-86 (1994).
8. Nemerson, Y. Tissue factor and hemostasis. Blood 71, 1-8 (1988).
9. Rickles, F.R., Levine, M.N. & Edwards, R.L. Hemostatic alterations in cancer patients. Cancer Metastasis Rev. 11, 237-248 (1992).
10. Dvorak, H.F., Dickersin, G.R., Dvorak, A.M., Manseau, J.E. & Pyne, K. Human breast carcinoma: Fibrin deposits and desmoplasia. J. Natl. Cancer Inst. 67, 335-340 (1981).
11. Maynard, J.R., Dreyer, B.E., Stemerman, M.B. & Pitlick, F.A. Tissue factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts. Blood 50, 387-396 (1977).
12. Stern, D.M., Nawroth, P.P, Handley, D. & Kisiel, W. An endothelial cell-dependent pathway of coagulation. Proc. Natl. Acad. Sci. USA 82, 2523-2527 (1982).