Coagulation-related gene expression profile in glioblastoma is defined by molecular disease subtype

Journal of Thrombosis and Haemostasis

Volumn 11, Issue 6, 2013, Pages 1197-1200

  Magnus, N ^a   Gerges, N ^a   Jabado, N ^a   Rak, J ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBOPLASTIN; TRANSCRIPTOME;

DEEP VEIN THROMBOSIS; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GLIOBLASTOMA; HEMOSTASIS; HUMAN; LETTER; LUNG EMBOLISM; PRIORITY JOURNAL; UPREGULATION;

BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; BRAIN NEOPLASMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTOME;

EID: 84883765614     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12242     Document Type: Letter

References (18)

1. Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359: 492-507.
2. Brat DJ, van Meir EG. Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma. Lab Invest 2004; 84: 397-405. Doi: 10.1038/labinvest.3700070.
3. Tehrani M, Friedman TM, Olson JJ, Brat DJ. Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastoma. Brain Pathol 2008; 18: 164-71. Doi:10.1111/j.1750-3639.2007.00108.x.
4. Perry JR. Thromboembolic disease in patients with high-grade glioma. Neuro Oncol 2012; 14(Suppl 4): iv73-80. Doi:10.1093/neuonc/nos197.
5. Sartori MT, Della Puppa A, Ballin A, Saggiorato G, Bernardi D, Padoan A, Scienza R, d'Avella D, Cella G. Prothrombotic state in glioblastoma multiforme: an evaluation of the procoagulant activity of circulating microparticles. J Neurooncol 2011; 104: 225-31. Doi:10.1007/s11060-010-0462-8.
6. Thaler J, Preusser M, Ay C, Kaider A, Marosi C, Zielinski C, Pabinger I, Hainfellner JA. Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients. Thromb Res 2013; 131: 162-5. doi:10.1016/j.thromres.2012.09.020 [Epub ahead of print].
7. Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 2005; 105: 1734-41. Doi:10.1182/blood-2004-05-2042.
8. Rak J, Yu JL, Luyendyk J, Mackman N. Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res 2006; 66: 10643-6. Doi:10.1158/0008-5472.CAN-06-2350.
9. Milsom CC YJ, Mackman N, Micallef J, Anderson GM, Guha A, Rak J. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis. Cancer Res 2008; 68: 10068-76.
10. Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, van Meir EG, Mackman N, Brat DJ. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res 2009; 69: 2540-9. Doi:10.1158/0008-5472.CAN-08-1547.
11. Magnus N, Garnier D, Rak J. Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells. Blood 2010; 116: 815-8.
12. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010; 17: 98-110. Doi:10.1016/j.ccr.2009.12.020.
13. Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tonjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22: 425-37. Doi:10.1016/j.ccr.2012.08.024.
14. Zheng S, Chheda MG, Verhaak RG. Studying a complex tumor: potential and pitfalls. Cancer J 2012; 18: 107-14.
15. Garnier D, Magnus N, D'Asti E, Hashemi M, Meehan B, Milsom C, Rak J. Genetic pathways linking hemostasis and cancer. Thromb Res 2012; 129(Suppl 1): S22-9.
16. Zhang Y, Zhan H, Xu W, Yuan Z, Lu P, Zhan L, Li Q. Upregulation of matrix metalloproteinase-1 and proteinase-activated receptor-1 promotes the progression of human gliomas. Pathol Res Pract 2011; 207: 24-9. Doi:10.1016/j.prp.2010.10.003.
17. Fernandez PM, Patierno SR, Rickles FR. Tissue factor and fibrin in tumor angiogenesis. Semin Thromb Hemost 2004; 30: 31-44.
18. Levine MN, Gu C, Liebman HA, Escalante CP, Solymoss S, Deitchman D, Ramirez L, Julian J. A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer. J Thromb Haemost 2012; 10: 807-14. Doi:10.1111/j.1538-7836.2012.04693.x.