Efficacy of bosentan, a dual ETA and ETB endothelin receptor antagonist, in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats

Pharmacology Biochemistry and Behavior

Volumn 124, Issue , 2014, Pages 27-35

  Singh, Gurpreet ^a   Sharma, Bhupesh ^b   Jaggi, Amteshwar Singh ^a   Singh, Nirmal ^a  

^a PUNJABI UNIVERSITY   (India)

^b BHARAT INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Diabetes; Moris water maze; Nitrite nitrate; Oxidative stress; Streptozotocin; Vascular dementia

Indexed keywords

ACETYLCHOLINESTERASE; BOSENTAN; DONEPEZIL; ENDOTHELIN RECEPTOR; GLUCOSE; GLUTATHIONE; NITRATE; NITRITE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; GLUCOSE BLOOD LEVEL; NITRIC ACID DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DEMENTIA; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; LATENT PERIOD; MALE; MORRIS WATER MAZE TEST; MOTOR COORDINATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; SPATIAL MEMORY; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; VASCULAR RING; ANIMAL; BRAIN; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; WISTAR RAT;

ACETYLCHOLINESTERASE; ANIMALS; BLOOD GLUCOSE; BRAIN; DEMENTIA; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIN A RECEPTOR ANTAGONISTS; ENDOTHELIN B RECEPTOR ANTAGONISTS; ENDOTHELIUM, VASCULAR; GLUTATHIONE; MALE; NITRATES; NITRITES; RATS; RATS, WISTAR; STREPTOZOCIN; SULFONAMIDES;

EID: 84901387170     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.05.002     Document Type: Article

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