Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia

Journal of the American Society of Hypertension

Volumn 3, Issue 5, 2009, Pages 295-305

  Javeshghani, Danesh ^a,b,c   Schiffrin, Ernesto L ^a   Sairam, M Ram ^b   Touyz, Rhian M ^c  

^a MCGILL UNIVERSITY   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; ANDROGEN; CATALASE; ESTROGEN; FOLLITROPIN RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL INJURY; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENDOTHELIAL DYSFUNCTION; ESTROGEN DEFICIENCY; FEMALE; HETEROZYGOSITY; HOMOZYGOSITY; HYPERANDROGENISM; HYPERTENSION; KNOCKOUT MOUSE; LIPID DIET; MENOPAUSE; MOUSE; MYOGRAPHY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUNICA MEDIA; VASCULITIS; VASODILATATION; WILD TYPE;

EID: 70349765872     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2009.07.002     Document Type: Article

References (50)

1. Davy K.P., and Hall J.E. Obesity and hypertension: two epidemics or one?. Am J Physiol Regul Integr Comp Physiol 286 (2004) R803-R813
2. Poirier P., Giles T.D., Bray G.A., Hong Y., Stern J.S., Pi-Sunyer F.X., and Eckel R.H. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol 26 (2006) 968-976
3. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87 (2000) 840-844
4. De Vriese A.S., Verbeuren T.J., van de Voorde J., Lameire N.H., and Vanhoutte P.M. Endothelial dysfunction in diabetes. Br J Pharmacol 130 (2000) 963-974
5. Serock M.R., Wells A.K., and Khalil R.A. Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Patents Cardiovasc Drug Discov 3 (2008) 165-186
6. Javeshghani D., Touyz R.M., Sairam M.R., Virdis A., Neves M.F., and Schiffrin E.L. Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension. Hypertension 42 (2003) 761-767
7. Reckelhoff J.F., and Fortepiani L.A. Novel mechanisms responsible for postmenopausal hypertension. Hypertension 43 (2004) 918-923
8. Shehata M., and Kamel M.A. Protective effect of antioxidant adjuvant treatment with hormone replacement therapy against cardiovascular diseases in ovariectomized rats. Endocr Regul 42 (2008) 69-75
9. Lopez-Ruiz A., Sartori-Valinotti J., Yanes L.L., Iliescu R., and Reckelhoff J.F. Sex differences in control of blood pressure: role of oxidative stress in hypertension in females. Am J Physiol Heart Circ Physiol 295 (2008) H466-H468
10. Lam K.K., Lee Y.M., Hsiao G., Chen S.Y., and Yen M.H. Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats. Menopause 13 (2006) 294-302
11. Liang W., Tan C.Y., Ang L., Sallam N., Granville D.J., Wright J.M., et al. Ramipril improves oxidative stress-related vascular endothelial dysfunction in db/db mice. J Physiol Sci 58 (2008) 405-411
12. Wang M.Y., Grayburn P., Chen S., Ravazzola M., Orci L., and Unger R.H. Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A 105 (2008) 6139-6144
13. Knudson J.D., Dincer U.D., Dick G.M., Shibata H., Akahane R., Saito M., et al. Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction. Am J Physiol Heart Circ Physiol 289 (2005) H1038-H1046
14. Fisher C.R., Graves K.H., Parlow A.F., and Simpson E.R. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A 95 (1998) 6965-6970
15. Sairam M.R., Danilovich N., and Lussier-Cacan S. The FORKO mouse as a genetic model for exploring estrogen replacement therapy. J Reprod Med 47 (2002) 412-418
16. Danilovich N., Babu P.S., Xing W., Gerdes M., Krishnamurthy H., and Sairam M.R. Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice. Endocrinology 141 (2000) 4295-4308
17. Misso M.L., Hewitt K.N., Boon W.C., Murata Y., Jones M.E., and Simpson E.R. Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse. Horm Metab Res 37 (2005) 26-31
18. Jones M.E., McInnes K.J., Boon W.C., and Simpson E.R. Estrogen and adiposity-utilizing models of aromatase deficiency to explore the relationship. J Steroid Biochem Mol Biol 106 (2007) 3-7
19. Zhang H., Chen X., Aravindakshan J., and Sairam M.R. Changes in adiponectin and inflammatory genes in response to hormonal imbalances in female mice and exacerbation of depot selective visceral adiposity by high-fat diet: implications for insulin resistance. Endocrinology 148 (2007) 5667-5669
20. Marcoux C., Tremblay M., Nakajima K., Davignon J., and Cohn J.S. Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients. J Lipid Res 40 (1999) 636-647
21. Rayalam S., Della-Fera M.A., and Baile C.A. Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem 19 (2008) 717-726
22. Yi K.W., Shin J.H., Seo H.S., Lee J.K., Oh M.J., Kim T., et al. Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes. Obesity (Silver Spring) 16 (2008) 2393-2399
23. Muraki K., Okuya S., and Tanizawa Y. Estrogen receptor alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes. Endocr J 53 (2006) 841-851
24. Blouin K., Nadeau M., Mailloux J., Daris M., Lebel S., Luu-The V., et al. Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis. Am J Physiol Endocrinol Metab 296 (2009) E244-E255
25. Wake D.J., Strand M., Rask E., Westerbacka J., Livingstone D.E., Soderberg S., et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf) 66 (2007) 440-446
26. Gooren L. Visceral obesity, the metabolic syndrome, androgens and estrogens. Aging Male 9 (2006) 75-79
27. Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril 85 (2006) 1319-1340
28. Schreyer S.A., Vick C., Lystig T.C., Mystkowski P., and LeBoeuf R.C. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282 (2002) E207-E214
29. Albers J.J., Pitman W., Wolfbauer G., Cheung M.C., Kennedy H., Tu A.Y., et al. Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains. J Lipid Res 40 (1999) 295-301
30. Shi Q., Vandeberg J.F., Jett C., Rice K., Leland M.M., Talley L., et al. Arterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet. Am J Clin Nutr 82 (2005) 751-759
31. Kobayashi K., Forte T.M., Taniguchi S., Ishida B.Y., Oka K., and Chan L. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49 (2000) 22-31
32. Aoki R., Ikarugi H., Naemura A., Ijiri Y., Yamashita T., and Yamamoto J. Endothelial dysfunction precedes atherosclerotic lesions and platelet activation in high-fat diet-induced prothrombotic state. Thromb Res 117 (2006) 529-535
33. Miller V.M., and Duckles S.P. Vascular actions of estrogens: functional implications. Pharmacol Rev 60 (2008) 210-241
34. Vouyouka A.G., and Kent K.C. Arterial vascular disease in women. J Vasc Surg 46 (2007) 1295-1302
35. Davies R.S., Vohra R.K., Bradbury A.W., and Adam D.J. The impact of hormone replacement therapy on the pathophysiology of peripheral arterial disease. Eur J Vasc Endovasc Surg 34 (2007) 569-575
36. Al Suwaidi J., Higano S.T., Holmes Jr. D.R., Lennon R., and Lerman A. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol 37 (2001) 1523-1528
37. Higashi Y., Sasaki S., Nakagawa K., Matsuura H., Chayama K., and Oshima T. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens 14 (2001) 1038-1045
38. Marchesi S., Vaudo G., Lupattelli G., Lombardini R., Roscini A.R., Brozzetti M., et al. Fat distribution and endothelial function in normal-overweight menopausal women. J Clin Pharm Ther 32 (2007) 477-482
39. Martin J.W., Briesmiester K., Bargardi A., Muzik O., Mosca L., and Duvernoy C.S. Weight changes and obesity predict impaired resting and endothelium-dependent myocardial blood flow in postmenopausal women. Clin Cardiol 28 (2005) 13-18
40. Bednarek-Tupikowska G., Tworowska-Bardzinska U., and Tupikowski K. Effects of estrogen and estrogen-progesteron on serum nitric oxide metabolite concentrations in post-menopausal women. J Endocrinol Invest 31 (2008) 877-881
41. Touyz R.M., and Schiffrin E.L. Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 122 (2004) 339-352
42. Forstermann U., and Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113 (2006) 1708-1714
43. Guzik T.J., West N.E., Pillai R., Taggart D.P., and Channon K.M. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension 39 (2002) 1088-1094
44. Noronha B.T., Li J.M., Wheatcroft S.B., Shah A.M., and Kearney M.T. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 54 (2005) 1082-1089
45. Moroe H., and Honda H. Comparison of endothelial function in the carotid artery between normal and short-term hypercholesterolemic rabbits. Comp Biochem Physiol C Toxicol Pharmacol 144 (2006) 197-203
46. Paravicini T.M., and Touyz R.M. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 31 (2008) S170-S180
47. Ebrahimian T., Sairam M.R., Schiffrin E.L., and Touyz R.M. Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. Am J Physiol Heart Circ Physiol 295 (2008) H1481-H1488
48. Erdei N., Toth A., Pasztor E.T., Papp Z., Edes I., Koller A., et al. High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion. Am J Physiol Heart Circ Physiol 291 (2006) H2107-H2115
49. Roberts C.K., Barnard R.J., Sindhu R.K., Jurczak M., Ehdaie A., and Vaziri N.D. A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression. J Appl Physiol 98 (2005) 203-210
50. Merat S., Casanada F., Sutphin M., Palinski W., and Reaven P.D. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arterioscler Thromb Vasc Biol 19 (1999) 1223-1230