Targeting endothelin receptors for pharmacotherapy of ischemic stroke: Current scenario and future perspectives

Drug Discovery Today

Volumn 17, Issue 13-14, 2012, Pages 793-804

  Kaundal, Ravinder K ^a,b   Deshpande, Tushar A ^a   Gulati, Anil ^c   Sharma, Shyam S ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MIDWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

27 O [3 [2 (3 CARBOXYACRYLOYLAMINO) 5 HYDROXYPHENYL]ACRYLOYLOXY]MYRICERONE; 3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; 4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ALPHA [[1 BUTYL 5 [2 [(2 CARBOXYPHENYL)METHOXY] 4 METHOXYPHENYL] 1H PYRAZOL 4 YL]METHYLENE] 6 METHOXY 1,3 BENZODIOXOLE 5 PROPANOIC ACID; AMBRISENTAN; ATRASENTAN; BOSENTAN; BQ 610; CLAZOSENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1 [11-21]; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN; IRL 2500; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N ACETYLENDOTHELIN 1 [6-21][11,15 ALANINE]; SARAFOTOXIN; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE]; TAK 044; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CEREBROSPINAL FLUID ANALYSIS; DRUG EFFICACY; DRUG MECHANISM; EXCITOTOXICITY; HUMAN; META ANALYSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; PATHOPHYSIOLOGY; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; HUMANS; NEUROPROTECTIVE AGENTS; RECEPTORS, ENDOTHELIN; SIGNAL TRANSDUCTION; STROKE;

EID: 84863532314     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.02.017     Document Type: Review

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