Diabetic-induced endothelial dysfunction in rat aorta: Role of hydroxyl radicals

Cardiovascular Research

Volumn 34, Issue 1, 1997, Pages 145-156

  Pieper, Galen M ^a,b   Langenstroer, Peter ^a   Siebeneich, Wolfgang ^a  

^a FROEDTERT MEMORIAL LUTHERAN HOSPITAL   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Aorta; Diabetes; Endothelium; Free radicals; Nitric oxide; Rat

Indexed keywords

ACETYLCHOLINE; CATALASE; GLYCERYL TRINITRATE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MANNITOL; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; PENTETIC ACID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ENDOTHELIUM CELL; ENDOTHELIUM LESION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; THORACIC AORTA;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; CATALASE; CYCLOOXYGENASE INHIBITORS; DIABETES MELLITUS, EXPERIMENTAL; DIURETICS, OSMOTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HYDROXYL RADICAL; INDOMETHACIN; MALE; MANNITOL; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROARGININE; NITROGLYCERIN; NOREPINEPHRINE; PHENYLACETATES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, THROMBOXANE; SULFONAMIDES; SUPEROXIDE DISMUTASE; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0030900360     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(96)00237-4     Document Type: Article

References (47)

1. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-666.
2. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-142.
3. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-4655.
4. Garg UC, Hassid S. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-1777.
5. Oyama Y, Kawasaki H, Hattori Y, Kanno M. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur J Pharmacol 1986;131:75-78.
6. Pieper GM, Gross GJ. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 1988;255:H825-H833.
7. Kamata K, Miyata N, Kasuya Y. Impairment of endothelium-dependent relaxation and changes on levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br J Pharmacol 1989;97:614-618.
8. 2. Am J Physiol 1989;257:H1327-H1333.
9. Mayhan WG, Simmons LK, Sharpe GM. Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am J Physiol 1991;260:H319-H326.
10. Diederich D, Skopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rat: role of free radicals. Am J Physiol 1994;266:H1153-H1161.
11. Taylor PD, Graves JE, Poston L. Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat. Clin Sci 1995;88:519-534.
12. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993;88:2510-2516.
13. McNally PG, Watt PAC, Rimmer T, Burdern AC, Hearnshaw JR, Thurston H. Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin Sci 1994;87:313-336.
14. McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35:771-776.
15. Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol 1992;263:H257-H265.
16. Pieper GM, Mei DA, Langenstroer P, O'Rourke ST. Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. Am J Physiol 1992;263:H676-H680.
17. 1-adrenoceptor stimulation in the absence and presence of extracellular calcium. J Cardiovasc Pharmacol 1990;16:239-248.
18. Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol 1995;25:397-403.
19. Pieper GM, Jordan M, Adams MB, Roza AM Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes. Diabetes 1995;44:1106-1113.
20. Rubanyi GM. Vascular effects of oxygen-derived free radicals. Free Radical Biol Med 1988;4:107-120.
21. Wolin MS. Activated oxygen metabolites as regulators of vascular tone. Klin Wochenschr 1991;69:1046-1049.
22. Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion plays a role in the breakdown of endothelium-derived relaxing factor. Nature 1986;320:454-456.
23. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 1989;257:H33-H37.
24. Burke TM, Wolin MS. Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation. Am J Physiol 1987;252:H721-H732
25. Kontos HA, Wei WP. Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke 1983;24:427-434.
26. Chang KC, Chung SY, Chong WS, et al. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 1993;266:992-1000.
27. Pieper GM. Oxidative stress in diabetic blood vessels. FASEB J 1995;9:A891(Abstract).
28. Ohishi K, Carmines PK. Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus. J Am Soc Nephrol 1995;5:559-1566.
29. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 1992;263:H321-H326.
30. Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 1991;261:H1086-H1094.
31. Heygate KM, Lawrence IG, Bennett MA, Thurston H. Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats. Br J Pharmacol 1995;116:3251-3259.
32. Dai FX, Diederich A, Skopec J, Diederich D. Diabetes-induced endothelial dysfunction in streptozotocin-treated rats: role of prostaglandin endoperoxides and free radicals. J Am Soc Nephrol 1993;4:1327-1336.
33. G-nitro-L-arginine in rats. Am J Physiol 1992;263:H1090-1094.
34. Endo K, Abiru T, Machida H, Kasuya Y, Kamata K. Endothelium-derived hyperpolarizing factor does not contribute to the decrease in endothelium-dependent relaxation in the aorta of streptozotocin-induced diabetic rat. Gen Pharmacol 1995;26:149-153.
35. Chang KSK, Stevens WC. Endothelium-dependent increase in vascular sensitivity to phenylephrine in long-term streptozotocin diabetic rat aorta. Br J Pharmacol 1992;107:983-990.
36. Taylor PD, Oon BB, Thomas CR, Poston L. Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetic rats. Br J Pharmacol 1994;111:35-41.
37. Pieper GM, Moore-Hilton G, Roza AM. Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat. Life Sci 1996;58:PL147-152.
38. Ohkuwa T, Sato Y, Naoi M. Hydroxyl radical formation in diabetic rats induced by streptozotocin. Life Sci 1995;56:1789-1798.
39. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. Generation of Superoxide by purified brain nitric oxide synthase. J Biol Chem 1992;267:24173-24176.
40. 2+ /calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. Biochem J 1992;281:627-630.
41. Pieper GM. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiovasc Pharmacol 1997;29:in press.
42. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-1624.
43. Ammar RF, Jr, Gutterman DD, Dellsperger KC. Topically applied superoxide dismutase and catalase normalize coronary arteriolar responses to acetylcholine in diabetes mellitus in vivo. Circulation 1994;90:I-574(Abstract)
44. Wolin MS, Belloni FL. Superoxide anion selectively attenuates catecholamine-induced contractile tension in isolated rabbit aorta. Am J Physiol 1985;249:H1127-H1133.
45. Otter DJ, Chess-Williams R. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol 1994;113:576-580.
46. Cameron NE, Cotter MA. Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway. Diabetologia 1992;35:1011-1019.
47. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitaimin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97:22-28.