-
1
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359
-
(2004)
Physiol Rev
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
2
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
-
(2009)
N Engl J Med
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
Lehman, S.2
Williams, G.3
-
4
-
-
65249122038
-
Obesity: Be cool, lose weight
-
Farmer SR. Obesity: be cool, lose weight. Nature 2009;458:839-840
-
(2009)
Nature
, vol.458
, pp. 839-840
-
-
Farmer, S.R.1
-
5
-
-
0027051199
-
Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
-
Cousin B, Cinti S, Morroni M, et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 1992;103:931-942
-
(1992)
J Cell Sci
, vol.103
, pp. 931-942
-
-
Cousin, B.1
Cinti, S.2
Morroni, M.3
-
6
-
-
0031011161
-
Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats
-
Ghorbani M, Himms-Hagen J. Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 1997;21:465-475
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 465-475
-
-
Ghorbani, M.1
Himms-Hagen, J.2
-
7
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
Barbatelli G, Murano I, Madsen L, et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab 2010;298:E1244-E1253
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Barbatelli, G.1
Murano, I.2
Madsen, L.3
-
8
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011; 121:96-105
-
(2011)
J Clin Invest
, vol.121
, pp. 96-105
-
-
Seale, P.1
Conroe, H.M.2
Estall, J.3
-
9
-
-
17944377509
-
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
-
Cederberg A, Grønning LM, Ahrén B, Taskén K, Carlsson P, Enerbäck S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 2001;106:563-573
-
(2001)
Cell
, vol.106
, pp. 563-573
-
-
Cederberg, A.1
Grønning, L.M.2
Ahrén, B.3
Taskén, K.4
Carlsson, P.5
Enerbäck, S.6
-
10
-
-
2942532305
-
Nuclear receptor corepressor RIP140 regulates fat accumulation
-
Leonardsson G, Steel JH, Christian M, et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A 2004;101:8437-8442
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8437-8442
-
-
Leonardsson, G.1
Steel, J.H.2
Christian, M.3
-
11
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparg
-
Qiang L, Wang L, Kon N, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparg. Cell 2012;150:620-632
-
(2012)
Cell
, vol.150
, pp. 620-632
-
-
Qiang, L.1
Wang, L.2
Kon, N.3
-
12
-
-
69349088117
-
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
-
Kajimura S, Seale P, Kubota K, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009;460: 1154-1158
-
(2009)
Nature
, vol.460
, pp. 1154-1158
-
-
Kajimura, S.1
Seale, P.2
Kubota, K.3
-
13
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008;454:961-967
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
Bjork, B.2
Yang, W.3
-
14
-
-
84862776702
-
A PGC1-A-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
Boström P, Wu J, Jedrychowski MP, et al. A PGC1-A-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-468
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Boström, P.1
Wu, J.2
Jedrychowski, M.P.3
-
15
-
-
84863012022
-
FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis
-
Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 2012; 26:271-281
-
(2012)
Genes Dev
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
-
16
-
-
68849107400
-
C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferatoractivated receptor gamma agonists
-
Vernochet C, Peres SB, Davis KE, et al. C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferatoractivated receptor gamma agonists. Mol Cell Biol 2009;29:4714-4728
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4714-4728
-
-
Vernochet, C.1
Peres, S.B.2
Davis, K.E.3
-
17
-
-
0032549811
-
A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998;92:829-839
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
18
-
-
31044432605
-
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
-
Powelka AM, Seth A, Virbasius JV, et al. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest 2006;116:125-136
-
(2006)
J Clin Invest
, vol.116
, pp. 125-136
-
-
Powelka, A.M.1
Seth, A.2
Virbasius, J.V.3
-
19
-
-
0037184960
-
SRC-1 and TIF2 control energy balance between white and brown adipose tissues
-
Picard F, Géhin M, Annicotte J, et al. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 2002;111:931-941
-
(2002)
Cell
, vol.111
, pp. 931-941
-
-
Picard, F.1
Géhin, M.2
Annicotte, J.3
-
20
-
-
12144287013
-
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
-
Hansen JB, Jørgensen C, Petersen RK, et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A 2004;101:4112-4117
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4112-4117
-
-
Hansen, J.B.1
Jørgensen, C.2
Petersen, R.K.3
-
21
-
-
33645064540
-
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha
-
Scimè A, Grenier G, Huh MS, et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab 2005;2:283-295
-
(2005)
Cell Metab
, vol.2
, pp. 283-295
-
-
Scimè, A.1
Grenier, G.2
Huh, M.S.3
-
22
-
-
84870595878
-
MyomiR-133 regulates brown fat differentiation through Prdm16
-
Trajkovski M, Ahmed K, Esau CC, Stoffel M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat Cell Biol 2012;14:1330-1335
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1330-1335
-
-
Trajkovski, M.1
Ahmed, K.2
Esau, C.C.3
Stoffel, M.4
-
23
-
-
84873327762
-
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16
-
Yin H, Pasut A, Soleimani VD, et al. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab 2013;17:210-224
-
(2013)
Cell Metab
, vol.17
, pp. 210-224
-
-
Yin, H.1
Pasut, A.2
Soleimani, V.D.3
-
24
-
-
84860009214
-
Essential role for miR-196a in brown adipogenesis of white fat progenitor cells
-
Mori M, Nakagami H, Rodriguez-Araujo G, Nimura K, Kaneda Y. Essential role for miR-196a in brown adipogenesis of white fat progenitor cells. PLoS Biol 2012;10:e1001314
-
(2012)
PLoS Biol
, vol.10
-
-
Mori, M.1
Nakagami, H.2
Rodriguez-Araujo, G.3
Nimura, K.4
Kaneda, Y.5
-
25
-
-
79960984113
-
Mir193b-365 is essential for brown fat differentiation
-
Sun L, Xie H, Mori MA, et al. Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol 2011;13:958-965
-
(2011)
Nat Cell Biol
, vol.13
, pp. 958-965
-
-
Sun, L.1
Xie, H.2
Mori, M.A.3
-
26
-
-
84877747920
-
MiR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit
-
Chen Y, Siegel F, Kipschull S, et al. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun 2013;4: 1769
-
(2013)
Nat Commun
, vol.4
, pp. 1769
-
-
Chen, Y.1
Siegel, F.2
Kipschull, S.3
-
27
-
-
0030969572
-
A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer
-
Min H, Turck CW, Nikolic JM, Black DL. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev 1997; 11:1023-1036
-
(1997)
Genes Dev
, vol.11
, pp. 1023-1036
-
-
Min, H.1
Turck, C.W.2
Nikolic, J.M.3
Black, D.L.4
-
28
-
-
2942612333
-
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
-
Gherzi R, Lee KY, Briata P, et al. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell 2004;14:571-583
-
(2004)
Mol Cell
, vol.14
, pp. 571-583
-
-
Gherzi, R.1
Lee, K.Y.2
Briata, P.3
-
29
-
-
67649277689
-
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
-
Trabucchi M, Briata P, Garcia-Mayoral M, et al. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 2009;459: 1010-1014
-
(2009)
Nature
, vol.459
, pp. 1010-1014
-
-
Trabucchi, M.1
Briata, P.2
Garcia-Mayoral, M.3
-
30
-
-
80053041963
-
Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)- dependent translational silencing mechanism
-
Dhamija S, Kuehne N, Winzen R, et al. Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)- dependent translational silencing mechanism. J Biol Chem 2011;286:33279-33288
-
(2011)
J Biol Chem
, vol.286
, pp. 33279-33288
-
-
Dhamija, S.1
Kuehne, N.2
Winzen, R.3
-
31
-
-
18044371822
-
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
-
Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001;107:451-464
-
(2001)
Cell
, vol.107
, pp. 451-464
-
-
Chen, C.Y.1
Gherzi, R.2
Ong, S.E.3
-
32
-
-
79961159449
-
Posttranscriptional control of type i interferon genes by KSRP in the innate immune response against viral infection
-
Lin WJ, Zheng X, Lin CC, et al. Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Mol Cell Biol 2011;31:3196-3207
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3196-3207
-
-
Lin, W.J.1
Zheng, X.2
Lin, C.C.3
-
33
-
-
0035823625
-
Distinct transcriptional profiles of adipogenesis in vivo and in vitro
-
Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem 2001; 276:34167-34174
-
(2001)
J Biol Chem
, vol.276
, pp. 34167-34174
-
-
Soukas, A.1
Socci, N.D.2
Saatkamp, B.D.3
Novelli, S.4
Friedman, J.M.5
-
34
-
-
0030763571
-
A simple method to predict cellular density in adipocyte metabolic incubations
-
Fine JB, DiGirolamo M. A simple method to predict cellular density in adipocyte metabolic incubations. Int J Obes Relat Metab Disord 1997;21:764-768
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 764-768
-
-
Fine, J.B.1
Digirolamo, M.2
-
35
-
-
84857052573
-
PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis
-
Briata P, Lin WJ, Giovarelli M, et al. PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis. Cell Death Differ 2012;19:478-487
-
(2012)
Cell Death Differ
, vol.19
, pp. 478-487
-
-
Briata, P.1
Lin, W.J.2
Giovarelli, M.3
-
36
-
-
84870472401
-
Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation
-
Pasero M, Giovarelli M, Bucci G, Gherzi R, Briata P. Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation. Cell Rep 2012;2:1159-1168
-
(2012)
Cell Rep
, vol.2
, pp. 1159-1168
-
-
Pasero, M.1
Giovarelli, M.2
Bucci, G.3
Gherzi, R.4
Briata, P.5
-
37
-
-
0742305338
-
Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA
-
Hall MP, Huang S, Black DL. Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. Mol Biol Cell 2004;15:774-786
-
(2004)
Mol Biol Cell
, vol.15
, pp. 774-786
-
-
Hall, M.P.1
Huang, S.2
Black, D.L.3
-
38
-
-
24144463983
-
Metabolic control through the PGC-1 family of transcription coactivators
-
Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005;1:361-370
-
(2005)
Cell Metab
, vol.1
, pp. 361-370
-
-
Lin, J.1
Handschin, C.2
Spiegelman, B.M.3
-
39
-
-
33644660537
-
PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
-
Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006;116:615-622
-
(2006)
J Clin Invest
, vol.116
, pp. 615-622
-
-
Finck, B.N.1
Kelly, D.P.2
-
40
-
-
33644652183
-
Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
-
Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 2006;116:571-580
-
(2006)
J Clin Invest
, vol.116
, pp. 571-580
-
-
Lefebvre, P.1
Chinetti, G.2
Fruchart, J.C.3
Staels, B.4
-
41
-
-
34547941361
-
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
-
Xiao C, Calado DP, Galler G, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 2007;131:146-159
-
(2007)
Cell
, vol.131
, pp. 146-159
-
-
Xiao, C.1
Calado, D.P.2
Galler, G.3
-
43
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98:115-124
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
-
44
-
-
79958047295
-
Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
-
Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 2011;13:739-748
-
(2011)
Cell Metab
, vol.13
, pp. 739-748
-
-
Ahmadian, M.1
Abbott, M.J.2
Tang, T.3
-
45
-
-
34347326271
-
Transcriptional control of brown fat determination by PRDM16
-
Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007;6:38-54
-
(2007)
Cell Metab
, vol.6
, pp. 38-54
-
-
Seale, P.1
Kajimura, S.2
Yang, W.3
-
46
-
-
83355163350
-
Peroxisome proliferator-Activated receptor a (PPARa) induces PPARg coactivator 1a (PGC-1a) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16
-
Hondares E, Rosell M, Díaz-Delfín J, et al. Peroxisome proliferator-Activated receptor a (PPARa) induces PPARg coactivator 1a (PGC-1a) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem 2011;286:43112-43122
-
(2011)
J Biol Chem
, vol.286
, pp. 43112-43122
-
-
Hondares, E.1
Rosell, M.2
Díaz-Delfín, J.3
-
47
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, Hall MN. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 2008;8:399-410
-
(2008)
Cell Metab
, vol.8
, pp. 399-410
-
-
Polak, P.1
Cybulski, N.2
Feige, J.N.3
Auwerx, J.4
Rüegg, M.A.5
Hall, M.N.6
-
48
-
-
0034770191
-
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
-
Tsukiyama-Kohara K, Poulin F, Kohara M, et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 2001;7:1128-1132
-
(2001)
Nat Med
, vol.7
, pp. 1128-1132
-
-
Tsukiyama-Kohara, K.1
Poulin, F.2
Kohara, M.3
-
49
-
-
73649094118
-
Deletion of tumor necrosis factoralpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
-
Romanatto T, Roman EA, Arruda AP, et al. Deletion of tumor necrosis factoralpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 2009;284:36213-36222
-
(2009)
J Biol Chem
, vol.284
, pp. 36213-36222
-
-
Romanatto, T.1
Roman, E.A.2
Arruda, A.P.3
-
50
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
Singh R, Xiang Y, Wang Y, et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009;119:3329-3339
-
(2009)
J Clin Invest
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
Xiang, Y.2
Wang, Y.3
-
51
-
-
51449123610
-
Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice
-
Toh SY, Gong J, Du G, et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One 2008;3:e2890
-
(2008)
PLoS One
, vol.3
-
-
Toh, S.Y.1
Gong, J.2
Du, G.3
-
52
-
-
84864705801
-
Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARg activation to decrease diet-induced obesity
-
Lodhi IJ, Yin L, Jensen-Urstad AP, et al. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARg activation to decrease diet-induced obesity. Cell Metab 2012;16:189-201
-
(2012)
Cell Metab
, vol.16
, pp. 189-201
-
-
Lodhi, I.J.1
Yin, L.2
Jensen-Urstad, A.P.3
|