Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33279-33288

  Dhamija, Sonam ^a   Kuehne, Nancy ^a   Winzen, Reinhard ^a   Doerrie, Anneke ^a   Dittrich Breiholz, Oliver ^a   Thakur, Basant Kumar ^a   Kracht, Michael ^b   Holtmann, Helmut ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AU-RICH ELEMENTS; CHEMOKINES; CONTROL-CELL; CYTOKINES; INFLAMMATORY GENES; INTERLEUKIN-1; INTERLEUKIN-6; NUCLEAR RIBONUCLEOPROTEIN; POST-TRANSCRIPTIONAL MECHANISMS; PROINFLAMMATORY CYTOKINES; PROTEIN EXPRESSIONS; PROTEIN SECRETION; RAPID DEGRADATION; REGULATORY PROTEIN; UNTRANSLATED REGIONS;

CELLS; DEGRADATION; GENE EXPRESSION; PROTEINS;

BIOSYNTHESIS;

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; K HOMOLOGY TYPE SPLICING REGULATORY PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; AU RICH ELEMENT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA STRUCTURE; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; INFLAMMATION; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; POLYSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA DEGRADATION; RNA INTERFERENCE; TRANSLATION REGULATION;

3' UNTRANSLATED REGIONS; AT RICH SEQUENCE; GENE SILENCING; HELA CELLS; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANS-ACTIVATORS;

EID: 80053041963     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264754     Document Type: Article

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