Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol

Neuroscience

Volumn 272, Issue , 2014, Pages 180-187

  Ramaker, M J ^a   Ford, M M ^a   Phillips, T J ^a,b   Finn, D A ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Alcohol; Allopregnanolone; Extrasynaptic; Relapse; THIP

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; GABOXADOL; GANAXOLONE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ELTANOLONE; ISOXAZOLE DERIVATIVE;

ALCOHOL ABSTINENCE; ALCOHOL BLOOD LEVEL; ALCOHOL SEEKING BEHAVIOR; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; LOCOMOTION; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SELF ADMINISTRATION TEST; TASK PERFORMANCE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; REINFORCEMENT;

ANIMALS; BEHAVIOR, ANIMAL; ETHANOL; EXTINCTION, PSYCHOLOGICAL; GABA AGONISTS; ISOXAZOLES; MALE; MICE, INBRED C57BL; PREGNANOLONE; RECEPTORS, GABA-A;

EID: 84901364945     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.04.065     Document Type: Article

References (66)

1. Anker J.J., Holtz N.A., Zlebnik N., Carroll M.E. Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats. Psychopharmacology (Berl) 2009, 203:63-72.
2. Barbaccia M.L., Serra M., Purdy R.H., Biggio G. Stress and neuroactive steroids. Int Rev Neurobiol 2001, 46:243-272.
3. A receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids?. J Neurosci 2003, 23:10013-10020.
4. A receptors. Neuropharmacology 2002, 43:651-661.
5. Besheer J., Lindsay T.G., O'Buckley T.K., Hodge C.W., Morrow A.L. Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring P rats. Alcohol Clin Exp Res 2010, 34:2044-2052.
6. Borghese C.M., Harris R.A. Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results. Alcohol 2007, 41:155-162.
7. Bowen C.A., Purdy R.H., Grant K.A. Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. J Pharmacol Exp Ther 1999, 289:405-411.
8. A receptor. J Pharmacol Exp Ther 1997, 280:1284-1295.
9. Childress A.R., Hole A.V., Ehrman R.N., Robbins S.J., McLellan A.T., O'Brien C.P. Cue reactivity and cue reactivity interventions in drug dependence. NIDA Res Monogr 1993, 137:73-95.
10. ClinicalTrials.gov. [accessed January 2014]. http://www.clinicaltrial.gov/ct2/results?term=allopregnanolone%26Search=Search.
11. ClinicalTrials.gov. [accessed January 2014]. http://www.clinicaltrial.gov/ct2/results?term=ganaxolone%26Search=Search.
12. ClinicalTrials.gov. [accessed January 2014]. http://www.clinicaltrial.gov/ct2/results?term=thip%26Search=Search.
13. Concas A., Mostallino M.C., Porcu P., Follesa P., Barbaccia M.L., Trabucchi M., Purdy R.H., Grisenti P., Biggio G. Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc Natl Acad Sci U S A 1998, 95:13284-13289.
14. Cremers T., Ebert B. Plasma and CNS concentrations of gaboxadol in rats following subcutaneous administration. Eur J Pharmacol 2007, 562:47-52.
15. de Wit H. Priming effects with drugs and other reinforcers. Exp Clin Psychopharmacol 1996, 4:5-10.
16. de Wit H., Stewart J. Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology (Berl) 1981, 75:134-143.
17. de Wit H., Stewart J. Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology (Berl) 1983, 79:29-31.
18. Epstein D.H., Preston K.L., Stewart J., Shaham Y. Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology (Berl) 2006, 189:1-16.
19. A receptors. Nat Rev Neurosci 2005, 6:215-229.
20. Finn D.A., Sinnott R.S., Ford M.M., Long S.L., Tanchuck M.A., Phillips T.J. Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 2004, 123:813-819.
21. Finn D.A., Snelling C., Fretwell A.M., Tanchuck M.A., Underwood L., Cole M., Crabbe J.C., Roberts A.J. Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist d-Phe-CRF(12-41). Alcohol Clin Exp Res 2007, 31:939-949.
22. Finn D.A., Mark G.P., Fretwell A.M., Gililland-Kaufman K.R., Strong M.N., Ford M.M. Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice. Psychopharmacology (Berl) 2008, 201:423-433.
23. Finn D.A., Beckley E.H., Kaufman K.R., Ford M.M. Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Horm Behav 2010, 57:12-22.
24. A receptors differentially modulate ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res 2005, 29:1630-1640.
25. Ford M.M., Mark G.P., Nickel J.D., Phillips T.J., Finn D.A. Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res 2007, 179:265-272.
26. Ford M.M., Fretwell A.M., Mark G.P., Finn D.A. Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice. Alcohol 2007, 41:21-29.
27. Grant K.A., Azarov A., Bowen C.A., Mirkis S., Purdy R.H. Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology (Berl) 1996, 124:340-346.
28. Grant K.A., Helms C.M., Rogers L.S.M., Purdy R.H. Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys. J Pharmacol Exp Ther 2008, 326:354-361.
29. Gubner N.R., McKinnon C.S., Reed C., Phillips T.J. Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. Drug Alcohol Depend 2013, 127:108-114.
30. Hodge C.W., Nannini M.A., Olive M.F., Kelley S.P., Mehmert K.K. Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. Alcohol Clin Exp Res 2001, 25:1441-1447.
31. Holmberg E., Bäckström T., Johansson M., Löfgren M., Haage D. Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats. Acta Physiol 2013, 208:400-409.
32. Holtz N.A., Lozama A., Prisinzano T.E., Carroll M.E. Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone. Drug Alcohol Depend 2012, 120:233-237.
33. A receptors through two discrete transmembrane sites. Nature 2006, 444:486-489.
34. Janak P.H., Gill T.M. Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose. Alcohol 2003, 30:1-7.
35. Janak P.H., Redfern J.E., Samson H.H. The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol Clin Exp Res 1998, 22:1106-1112.
36. A receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 2009, 205:529-564.
37. Leshner A.I. Addiction is a brain disease, and it matters. Science 1997, 278:45-47.
38. A receptors. J Neurosci 2006, 26:1749-1758.
39. A receptor plasticity after ethanol intoxication. J Neurosci 2007, 27:12367-12377.
40. A receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci 2005, 8:797-804.
41. A receptors. J Neurophysiol 2011, 106:2057-2064.
42. A receptors and inhibition of neurosteroid synthesis have separable estrous-dependent effects on binge drinking in female mice. Alcohol Clin Exp Res 2012, 36:184A.
43. Mihalek R.M., Banerjee P.K., Korpi E.R., Quinlan J.J., Firestone L., Mi Z.P., Lagenaur C., Tretter V., Sieghart W., Anagnostaras S.G., Sage J.R., Fanselow M.S., Guidotti A., Spigelman I., Li Z., DeLorey T.M., Olsen R.W., Homanics G.E. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A 1999, 96:12905-12910.
44. A receptor δ subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol Clin Exp Res 2001, 25:1708-1718.
45. Mody I., Glykys J., Wei W. A new meaning for "Gin & Tonic": tonic inhibition as the target for ethanol action in the brain. Alcohol 2007, 41:145-153.
46. Nie H., Janak P.H. Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats. Psychopharmacology (Berl) 2003, 168:222-228.
47. Nohria V., Giller E. Ganaxolone. Neurotherapeutics 2007, 4:102-105.
48. A receptor subtypes: the "one glass of wine" receptors. Alcohol 2007, 41:201-209.
49. Polich J.M., Armor D.J., Braiker H.B. Patterns of alcoholism over four years. J Stud Alcohol 1980, 41:397-416.
50. Purdy R.H., Morrow A.L., Moore P.H., Paul S.M. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci U S A 1991, 88:4553-4557.
51. A receptor with ganaxolone, finasteride, and gaboxadol. Alcohol Clin Exp Res 2011, 35:1994-2007.
52. Ramaker M.J., Strong M.N., Ford M.M., Finn D.A. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration. Neuropharmacology 2012, 63:555-564.
53. Reddy D.S., Rogawski M.A. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 2000, 295:1241-1248.
54. Samson H.H., Slawecki C.J., Sharpe A.L., Chappell A. Appetitive and consummatory behaviors in the control of ethanol consumption: a measure of ethanol seeking behavior. Alcohol Clin Exp Res 1998, 22:1783-1787.
55. Seo D., Lacadie C.M., Tuit K., Hong K.I., Constable R.T., Sinha R. Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk. JAMA psychiatry 2013, 70:727-739.
56. Shaham Y., Shalev U., Lu L., de Wit H., Stewart J. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) 2003, 168:3-20.
57. Shannon E.E., Shelton K.L., Vivian J.A., Yount I., Morgan A.R., Homanics G.E., Grant K.A. Discriminative stimulus effects of ethanol in mice lacking the γ-aminobutyric acid type A receptor δ subunit. Alcohol Clin Exp Res 2004, 28:906-913.
58. Shelton K.L., Grant K.A. Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. Alcohol Clin Exp Res 2002, 26:747-757.
59. Sinha R. How does stress increase risk of drug abuse and relapse?. Psychopharmacology (Berl) 2001, 158:343-359.
60. Sinnott R.S., Phillips T.J., Finn D.A. Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology (Berl) 2002, 162:438-447.
61. Stewart J. Conditioned and unconditioned drug effects in relapse to opiate and stimulant drug self-administration. Prog Neuropsychopharmacol Biol Psychiatry 1983, 7:591-597.
62. Timby E., Ballard M., Nyberg S., Spigset O., Andersson A., Porankiewicz-Asplund J., Purdy R.H., Zhu D., Bäckström T. Pharmacokinetic and behavioral effects of allopregnanolone in healthy women. Psychopharmacology (Berl) 2006, 186:414-424.
63. Ungard J.T., Beekman M., Gasior M., Carter R.B., Dijkstra D., Witkin J.M. Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology (Berl) 2000, 148:336-343.
64. VanDoren M.J., Matthews D.B., Janis G.C., Grobin A.C., Devaud L.L., Morrow A.L. Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 2000, 20:1982-1989.
65. Volkow N.D., Li T.K. Drugs and alcohol: treating and preventing abuse, addiction and their medical consequences. Pharmacol Ther 2005, 108:3-17.
66. A receptors and increase tonic currents in thalamus. Neuropharmacology 2009, 56:182-189.