The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 5, 1998, Pages 1106-1112

  Janak, Patricia H ^a,b   Redfern, Jane E M ^a   Samson, Herman H ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

3 Hydroxy 5 pregnan 20 one; Alcohol Addiction; GABA Receptor; Reinforcement; Self administration

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; NEUROSTEROID;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG RECEPTOR BINDING; INSTRUMENTAL CONDITIONING; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE METABOLISM; PURKINJE CELL; RAT; RECEPTOR AFFINITY; REINFORCEMENT;

ANIMALIA;

EID: 0031657919     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1998.tb03708.x     Document Type: Article

References (39)

1. Corpechot C, Young J, Calvel M, Wehrey C, Veltz JN, Touyer G, Mouren M, Prasad VK, Banner C, Sjovall J, Baulieu EE, Robel P: Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 133:1003-1009, 1993
2. Purdy RH, Moore PH, Rao PN, Hagino N, Yamaguchi T, Schmidt P, Rubinow DR, Morrow AL, Paul SM: Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma. Steroids 55:290-296, 1990
3. Balieu EE: Steroid hormones in the brain: several mechanisms?, in Fuxe K, Gustafsson JA, Wetterberg L (eds): Steroid Hormone Regulation of the Brain, Oxford, Pergamon Press, 1981, p 3
4. Baulieu EE: Neurosteroids: An overview, in Biggio G, Concas A, Costa E (eds): GABAergic Synaptic Transmission. New York, Raven Press, 1992, p 1
5. A receptor coupled steroid recognition site, in Biggio G, Concas A, Costa E (eds): GABAergic Synaptic Transmission. New York, Raven Press, 1992, p 111
6. A receptor complex. J Pharmacol Exp Ther 241:346-353, 1987
7. A receptor function. Trends Pharmacol Sci 16:295-303, 1995
8. A receptor mechanism of action and physiological significance. Prog Neurobiol 38:379-395, 1992
9. Paul SM, Purdy RH: Neuroactive steroids. FASEB J 6:2311-2322, 1992
10. Purdy RH, Morrow AL, Blinn JR, Paul SM: Synthesis, metabolism, and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. J Med Chem 33:1572-1581, 1990
11. A channel deactivation by altering kinetics of desensitized states. J Neurosci 17:4022-4031, 1997
12. Smith SS: Female sex steroid hormones: From receptors to networks to performance-actions on the sensorimotor system. Prog Neurobiol 44:55-86, 1994
13. Smith SS, Waterhouse BD, Chapin JK, Woodward DJ: Progesterone alters GABA and glutamate responsiveness: A possible mechanism for its anxiolytic action. Brain Res 400:353-359, 1987
14. Smith SS, Waterhouse BD, Woodward DJ: Locally applied progesterone metabolites alter neuronal responsiveness to iontophoretically applied glutamate in the cerebellum. Brain Res Bull 18:739-747, 1987
15. A receptor. Brain Res 561:157-161, 1991
16. Carboni E, Wieland S, Lan N, Gee K: Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety. Psychopharmacology 126:173-178, 1996
17. Wieland S, Lan N, Mirasedeghi S, Gee K: Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res 565:263-268, 1991
18. Wieland S, Belluzzi JD, Stein L, Lan N: Comparative behavioral characterization of the neuroactive steroids 3α-OH, 5α-pregnan-20-one and 3α-OH, 5β-pregnan-20-one in rodents. Psychopharmacology 118:65-71, 1995
19. Melchior CL, Allen PM: Interaction of pregnanolone and pregnenalone sulfate with ethanol and pentobarbital. Pharmacol Biochem Behav 42:605-611, 1992
20. Grant KA: Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5:383-404, 1994
21. A receptor/ chloride channel complex, in Deitrich RA, Erwin VG (eds): Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, CRC Press, 1996, p 51
22. Draski LJ, Deitrich RA: Initial effects of ethanol on the central nervous system, in Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, CRC Press, 1996, p 227
23. Koob GF, Britton KT: Neurobiological substrates for the antianxiety effects of ethanol, in Begleiter, Kissin B (eds): Alcohol and Alcoholism, vol 2. New York, Oxford University Press, 1994, p x
24. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR: Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237-243, 1993
25. Grant KA, Azarov A, Bowen CA: Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-predgnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology 124:340-346, 1996
26. McBride WJ, Murphy JM, Lumeng L, Li T-K: Effects of Ro15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacol Biochem Behav 30:1045-1050, 1988
27. Petry NM: Ro 15-4513 selectively attenuates ethanol, but not sucrose, reinforced responding in a concurrent access procedure: Comparison to other drugs. Psychopharmacology 121:192-203, 1995
28. Rassnick S, D'Amico E, Rile E, Koob GF: GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol. Alcohol Clin Exp Res 17:124-130, 1993
29. Samson HH, Tolliver GA, Pfeffer AO, Sadeghi KG, Mills FG: Oral ethanol reinforcement in the rat: Effect of the partial inverse benzodiazepine agonist Ro15-4513. Pharmacol Biochem Behav 27:517-519, 1987
30. Samson HH, Haraguchi M, Tolliver GA, Sadeghi KG: antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonist Ro15-4513 and FG 7142: Relation to sucrose reinforcement. Pharmacol Biochem Behav 33:601-608, 1989
31. Samson HH, Grant KA: Chlordiazepoxide effects on ethanol self-administration: Dependence on concurrent conditions. J Exp Anal Behav 43:353-364, 1985
32. Hodge CW, Chappelle AM, Samson HH: Gabaergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcohol Clin Exp Res 19:1486-1493, 1995
33. Roberts AJ, Cole M, Koob GF: Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res 20:1289-1298, 1996
34. a agonist muscimol on self-administration of ethanol and sucrose. Pharmacol Biochem Behav 53:971-977, 1996
35. Hyytia P, Koob GF: GABA-A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283:151-159, 1995
36. Samson HH: Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10:436-442, 1986
37. Samson HH, Pferrer AO, Tolliver GA: Oral ethanol self-administration in rats: Models of alcohol-seeking behavior. Alcohol Clin Exp Res 12:591-598, 1988
38. Slawecki CJ, Samson HH: Changes in oral ethanol self-administration patterns resulting from ethanol concentration manipulations. Alcohol Clin Exp Res 21:1144, 1997
39. Bejanian M, Crabbe JC, Brinton RD, Alkana RL: Interaction of ethanol and the neurosteroid 3α-hydroxy-5α-pregnan-20-one (3α,5α-P) on GABA-stimulated chloride uptake in withdrawal seizure prone (WSP) mice: Preliminary studies. Alcohol Clin Exp Res 17:476, 1993