메뉴 건너뛰기




Volumn 41, Issue 3, 2007, Pages 145-153

A new meaning for "Gin & Tonic": tonic inhibition as the target for ethanol action in the brain

Author keywords

Ethanol; GABAARs; Inhibition; Neurosteroids; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; CHLORIDE ION; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; NEUROSTEROID; NEUROTRANSMITTER; RECEPTOR SUBUNIT;

EID: 34250708068     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2007.03.009     Document Type: Review
Times cited : (54)

References (86)
  • 1
    • 0025196915 scopus 로고
    • Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons
    • Aguayo L.G. Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons. Eur. J. Pharmacol. 187 (1990) 127-130
    • (1990) Eur. J. Pharmacol. , vol.187 , pp. 127-130
    • Aguayo, L.G.1
  • 3
    • 0037322886 scopus 로고    scopus 로고
    • Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function
    • Akk G., and Steinbach J.H. Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. J. Physiol. 546 (2003) 641-646
    • (2003) J. Physiol. , vol.546 , pp. 641-646
    • Akk, G.1    Steinbach, J.H.2
  • 4
    • 0035057513 scopus 로고    scopus 로고
    • Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    • Bai D., Zhu G., Pennefather P., Jackson M.F., MacDonald J.F., and Orser B.A. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Mol. Pharmacol. 59 (2001) 814-824
    • (2001) Mol. Pharmacol. , vol.59 , pp. 814-824
    • Bai, D.1    Zhu, G.2    Pennefather, P.3    Jackson, M.F.4    MacDonald, J.F.5    Orser, B.A.6
  • 5
    • 21744447595 scopus 로고    scopus 로고
    • Neurosteroids: endogenous regulators of the GABA(A) receptor
    • Belelli D., and Lambert J.J. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat. Rev. Neurosci. 6 (2005) 565-575
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 565-575
    • Belelli, D.1    Lambert, J.J.2
  • 6
    • 0345491872 scopus 로고    scopus 로고
    • Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns
    • Bianchi M.T., and Macdonald R.L. Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. J. Neurosci. 23 (2003) 10934-10943
    • (2003) J. Neurosci. , vol.23 , pp. 10934-10943
    • Bianchi, M.T.1    Macdonald, R.L.2
  • 7
    • 0034049203 scopus 로고    scopus 로고
    • Spontaneously opening GABA(A) channels in CA1 pyramidal neurons of rat hippocampus
    • Birnir B., Everitt A.B., Lim M.S., and Gage P.W. Spontaneously opening GABA(A) channels in CA1 pyramidal neurons of rat hippocampus. J. Membr. Biol. 174 (2000) 21-29
    • (2000) J. Membr. Biol. , vol.174 , pp. 21-29
    • Birnir, B.1    Everitt, A.B.2    Lim, M.S.3    Gage, P.W.4
  • 8
    • 33846178261 scopus 로고    scopus 로고
    • From gene to behavior and back again: new perspectives on GABAA receptor subunit selectivity of alcohol actions
    • Boehm S.L., Ponomarev I., Blednov Y.A., and Harris R.A. From gene to behavior and back again: new perspectives on GABAA receptor subunit selectivity of alcohol actions. Adv. Pharmacol. 54 (2006) 171-203
    • (2006) Adv. Pharmacol. , vol.54 , pp. 171-203
    • Boehm, S.L.1    Ponomarev, I.2    Blednov, Y.A.3    Harris, R.A.4
  • 11
    • 0035804244 scopus 로고    scopus 로고
    • Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    • Brickley S.G., Revilla V., Cull-Candy S.G., Wisden W., and Farrant M. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409 (2001) 88-92
    • (2001) Nature , vol.409 , pp. 88-92
    • Brickley, S.G.1    Revilla, V.2    Cull-Candy, S.G.3    Wisden, W.4    Farrant, M.5
  • 14
    • 4744367001 scopus 로고    scopus 로고
    • Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences
    • Cavelier P., Hamann M., Rossi D., Mobbs P., and Attwell D. Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences. Prog. Biophys. Mol. Biol. 87 (2005) 3-16
    • (2005) Prog. Biophys. Mol. Biol. , vol.87 , pp. 3-16
    • Cavelier, P.1    Hamann, M.2    Rossi, D.3    Mobbs, P.4    Attwell, D.5
  • 17
    • 0025287776 scopus 로고
    • Alcohol consumption and menstrual distress in women at higher and lower risk for alcoholism
    • Charette L., Tate D.L., and Wilson A. Alcohol consumption and menstrual distress in women at higher and lower risk for alcoholism. Alcohol. Clin. Exp. Res. 14 (1990) 152-157
    • (1990) Alcohol. Clin. Exp. Res. , vol.14 , pp. 152-157
    • Charette, L.1    Tate, D.L.2    Wilson, A.3
  • 18
    • 30744441624 scopus 로고    scopus 로고
    • GABAA receptor-mediated tonic inhibition in thalamic neurons
    • Cope D.W., Hughes S.W., and Crunelli V. GABAA receptor-mediated tonic inhibition in thalamic neurons. J. Neurosci. 25 (2005) 11553-11563
    • (2005) J. Neurosci. , vol.25 , pp. 11553-11563
    • Cope, D.W.1    Hughes, S.W.2    Crunelli, V.3
  • 19
    • 0033884270 scopus 로고    scopus 로고
    • GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors
    • Dalby N.O. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 (2000) 2399-2407
    • (2000) Neuropharmacology , vol.39 , pp. 2399-2407
    • Dalby, N.O.1
  • 20
    • 0015541247 scopus 로고
    • Alcohol and presynaptic inhibition in an isolated spinal cord preparation
    • Davidoff R.A. Alcohol and presynaptic inhibition in an isolated spinal cord preparation. Arch. Neurol. 28 (1973) 60-63
    • (1973) Arch. Neurol. , vol.28 , pp. 60-63
    • Davidoff, R.A.1
  • 21
    • 33745788345 scopus 로고    scopus 로고
    • THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex
    • Drasbek K.R., and Jensen K. THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex. Cereb. Cortex 16 (2006) 1134-1141
    • (2006) Cereb. Cortex , vol.16 , pp. 1134-1141
    • Drasbek, K.R.1    Jensen, K.2
  • 22
    • 14844323722 scopus 로고    scopus 로고
    • Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    • Farrant M., and Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat. Rev. Neurosci. 6 (2005) 215-229
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 215-229
    • Farrant, M.1    Nusser, Z.2
  • 23
    • 33646170001 scopus 로고    scopus 로고
    • Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice
    • Glykys J., and Mody I. Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice. J. Neurophysiol. 95 (2006) 2796-2807
    • (2006) J. Neurophysiol. , vol.95 , pp. 2796-2807
    • Glykys, J.1    Mody, I.2
  • 24
    • 34250789872 scopus 로고    scopus 로고
    • Glykys, J., and Mody, I. (2006). The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J. Physiol., in press.
  • 25
    • 33845866861 scopus 로고    scopus 로고
    • A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol
    • Glykys J., Peng Z., Chandra D., Homanics G.E., Houser C.R., and Mody I. A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. Nat. Neurosci. 10 (2007) 40-48
    • (2007) Nat. Neurosci. , vol.10 , pp. 40-48
    • Glykys, J.1    Peng, Z.2    Chandra, D.3    Homanics, G.E.4    Houser, C.R.5    Mody, I.6
  • 26
    • 27744493861 scopus 로고    scopus 로고
    • GABAergic neurons in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: plasticity of expression during the estrous cycle
    • Griffiths J.L., and Lovick T.A. GABAergic neurons in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: plasticity of expression during the estrous cycle. Neuroscience 136 (2005) 457-466
    • (2005) Neuroscience , vol.136 , pp. 457-466
    • Griffiths, J.L.1    Lovick, T.A.2
  • 27
    • 14544274549 scopus 로고    scopus 로고
    • Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity
    • Hanchar H.J., Dodson P.D., Olsen R.W., Otis T.S., and Wallner M. Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Nat. Neurosci. 8 (2005) 339-345
    • (2005) Nat. Neurosci. , vol.8 , pp. 339-345
    • Hanchar, H.J.1    Dodson, P.D.2    Olsen, R.W.3    Otis, T.S.4    Wallner, M.5
  • 28
    • 6344280010 scopus 로고    scopus 로고
    • Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer?
    • Hanchar H.J., Wallner M., and Olsen R.W. Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer?. Life Sci. 76 (2004) 1-8
    • (2004) Life Sci. , vol.76 , pp. 1-8
    • Hanchar, H.J.1    Wallner, M.2    Olsen, R.W.3
  • 30
    • 33751314737 scopus 로고    scopus 로고
    • Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
    • Hosie A.M., Wilkins M.E., da Silva H.M., and Smart T.G. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 444 (2006) 486-489
    • (2006) Nature , vol.444 , pp. 486-489
    • Hosie, A.M.1    Wilkins, M.E.2    da Silva, H.M.3    Smart, T.G.4
  • 31
    • 0142058598 scopus 로고    scopus 로고
    • GABA Transporter-1 (GAT1) deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus
    • Jensen K., Chiu C.S., Sokolova I., Lester H.A., and Mody I. GABA Transporter-1 (GAT1) deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. J. Neurophysiol. 90 (2003) 2690-2701
    • (2003) J. Neurophysiol. , vol.90 , pp. 2690-2701
    • Jensen, K.1    Chiu, C.S.2    Sokolova, I.3    Lester, H.A.4    Mody, I.5
  • 33
    • 0029028314 scopus 로고
    • Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum
    • Kaneda M., Farrant M., and Cull-Candy S.G. Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum. J. Physiol. (Lond.) 485 (1995) 419-435
    • (1995) J. Physiol. (Lond.) , vol.485 , pp. 419-435
    • Kaneda, M.1    Farrant, M.2    Cull-Candy, S.G.3
  • 35
    • 1542718638 scopus 로고    scopus 로고
    • Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms
    • Kumar S., Fleming R.L., and Morrow A.L. Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol. Ther. 101 (2004) 211-226
    • (2004) Pharmacol. Ther. , vol.101 , pp. 211-226
    • Kumar, S.1    Fleming, R.L.2    Morrow, A.L.3
  • 37
    • 32544436243 scopus 로고    scopus 로고
    • Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors
    • Liang J., Zhang N., Cagetti E., Houser C.R., Olsen R.W., and Spigelman I. Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. J. Neurosci. 26 (2006) 1749-1758
    • (2006) J. Neurosci. , vol.26 , pp. 1749-1758
    • Liang, J.1    Zhang, N.2    Cagetti, E.3    Houser, C.R.4    Olsen, R.W.5    Spigelman, I.6
  • 38
    • 33745403750 scopus 로고    scopus 로고
    • Plasticity of GABAA receptor subunit expression during the oestrous cycle of the rat: implications for premenstrual syndrome in women
    • Lovick T.A. Plasticity of GABAA receptor subunit expression during the oestrous cycle of the rat: implications for premenstrual syndrome in women. Exp. Physiol. 91 (2006) 655-660
    • (2006) Exp. Physiol. , vol.91 , pp. 655-660
    • Lovick, T.A.1
  • 39
    • 13544275655 scopus 로고    scopus 로고
    • Changes in GABA(A) receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats
    • Lovick T.A., Griffiths J.L., Dunn S.M., and Martin I.L. Changes in GABA(A) receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats. Neuroscience 131 (2005) 397-405
    • (2005) Neuroscience , vol.131 , pp. 397-405
    • Lovick, T.A.1    Griffiths, J.L.2    Dunn, S.M.3    Martin, I.L.4
  • 40
    • 22844431788 scopus 로고    scopus 로고
    • Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety
    • Maguire J.L., Stell B.M., Rafizadeh M., and Mody I. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat. Neurosci. 8 (2005) 797-804
    • (2005) Nat. Neurosci. , vol.8 , pp. 797-804
    • Maguire, J.L.1    Stell, B.M.2    Rafizadeh, M.3    Mody, I.4
  • 41
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., and Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232 (1986) 1004-1007
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 42
    • 33846406886 scopus 로고    scopus 로고
    • Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating
    • McCartney M.R., Deeb T.Z., Henderson T.N., and Hales T.G. Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating. Mol. Pharmacol. 71 (2006) 539-548
    • (2006) Mol. Pharmacol. , vol.71 , pp. 539-548
    • McCartney, M.R.1    Deeb, T.Z.2    Henderson, T.N.3    Hales, T.G.4
  • 43
    • 0028289614 scopus 로고
    • Family history of alcoholism in women with generalized anxiety disorder who have premenstrual syndrome: patient reports of premenstrual alcohol consumption and symptoms of anxiety
    • McLeod D.R., Foster G.V., Hoehn-Saric R., Svikis D.S., and Hipsley P.A. Family history of alcoholism in women with generalized anxiety disorder who have premenstrual syndrome: patient reports of premenstrual alcohol consumption and symptoms of anxiety. Alcohol Clin. Exp. Res. 18 (1994) 664-670
    • (1994) Alcohol Clin. Exp. Res. , vol.18 , pp. 664-670
    • McLeod, D.R.1    Foster, G.V.2    Hoehn-Saric, R.3    Svikis, D.S.4    Hipsley, P.A.5
  • 44
    • 0022370066 scopus 로고
    • Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?
    • Mereu G., and Gessa G.L. Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?. Brain Res. 360 (1985) 325-330
    • (1985) Brain Res. , vol.360 , pp. 325-330
    • Mereu, G.1    Gessa, G.L.2
  • 45
    • 0034764735 scopus 로고    scopus 로고
    • Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances
    • Mody I. Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances. Neurochem. Res. 26 (2001) 907-913
    • (2001) Neurochem. Res. , vol.26 , pp. 907-913
    • Mody, I.1
  • 46
    • 4344707812 scopus 로고    scopus 로고
    • Diversity of inhibitory neurotransmission through GABA(A) receptors
    • Mody I., and Pearce R.A. Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends Neurosci. 27 (2004) 569-575
    • (2004) Trends Neurosci. , vol.27 , pp. 569-575
    • Mody, I.1    Pearce, R.A.2
  • 47
    • 33845345567 scopus 로고    scopus 로고
    • Extrasynaptic {alpha}{beta} subunit GABAA receptors on rat hippocampal pyramidal neurons
    • Mortensen M., and Smart T.G. Extrasynaptic {alpha}{beta} subunit GABAA receptors on rat hippocampal pyramidal neurons. J. Physiol. 577 (2006) 841-856
    • (2006) J. Physiol. , vol.577 , pp. 841-856
    • Mortensen, M.1    Smart, T.G.2
  • 48
    • 0035319805 scopus 로고    scopus 로고
    • Constructing inhibitory synapses
    • Moss S.J., and Smart T.G. Constructing inhibitory synapses. Nat. Rev. Neurosci. 2 (2001) 240-250
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 240-250
    • Moss, S.J.1    Smart, T.G.2
  • 49
    • 0018860366 scopus 로고
    • Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex
    • Nestoros J.N. Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex. Science 209 (1980) 708-710
    • (1980) Science , vol.209 , pp. 708-710
    • Nestoros, J.N.1
  • 50
    • 0036097970 scopus 로고    scopus 로고
    • Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    • Nusser Z., and Mody I. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J. Neurophysiol. 87 (2002) 2624-2628
    • (2002) J. Neurophysiol. , vol.87 , pp. 2624-2628
    • Nusser, Z.1    Mody, I.2
  • 51
    • 0032008543 scopus 로고    scopus 로고
    • Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
    • Nusser Z., Sieghart W., and Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18 (1998) 1693-1703
    • (1998) J. Neurosci. , vol.18 , pp. 1693-1703
    • Nusser, Z.1    Sieghart, W.2    Somogyi, P.3
  • 52
    • 33744475611 scopus 로고    scopus 로고
    • Extracellular level of GABA and Glu: in vivo microdialysis-HPLC measurements
    • Nyitrai G., Kekesi K.A., and Juhasz G. Extracellular level of GABA and Glu: in vivo microdialysis-HPLC measurements. Curr. Top. Med. Chem. 6 (2006) 935-940
    • (2006) Curr. Top. Med. Chem. , vol.6 , pp. 935-940
    • Nyitrai, G.1    Kekesi, K.A.2    Juhasz, G.3
  • 53
    • 0025775059 scopus 로고
    • Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release
    • Otis T.S., Staley K.J., and Mody I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res. 545 (1991) 142-150
    • (1991) Brain Res. , vol.545 , pp. 142-150
    • Otis, T.S.1    Staley, K.J.2    Mody, I.3
  • 54
    • 4143150583 scopus 로고    scopus 로고
    • Premenstrual symptomatology and alcohol consumption in college women
    • Perry B.L., Miles D., Burruss K., and Svikis D.S. Premenstrual symptomatology and alcohol consumption in college women. J. Stud. Alcohol. 65 (2004) 464-468
    • (2004) J. Stud. Alcohol. , vol.65 , pp. 464-468
    • Perry, B.L.1    Miles, D.2    Burruss, K.3    Svikis, D.S.4
  • 56
    • 0037340216 scopus 로고    scopus 로고
    • Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking δ subunit
    • Porcello D.M., Huntsman M.M., Mihalek R.M., Homanics G.E., and Huguenard J.R. Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking δ subunit. J. Neurophysiol. 89 (2003) 1378-1386
    • (2003) J. Neurophysiol. , vol.89 , pp. 1378-1386
    • Porcello, D.M.1    Huntsman, M.M.2    Mihalek, R.M.3    Homanics, G.E.4    Huguenard, J.R.5
  • 58
    • 0029666317 scopus 로고    scopus 로고
    • A receptor-mediated inhibitory currents in adult rat somatosensory cortex
    • A receptor-mediated inhibitory currents in adult rat somatosensory cortex. J. Neurophysiol. 75 (1996) 1573-1588
    • (1996) J. Neurophysiol. , vol.75 , pp. 1573-1588
    • Salin, P.A.1    Prince, D.A.2
  • 59
    • 33645243793 scopus 로고    scopus 로고
    • Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene
    • Santhakumar V., Hanchar H.J., Wallner M., Olsen R.W., and Otis T.S. Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. J. Neurosci. 26 (2006) 3357-3364
    • (2006) J. Neurosci. , vol.26 , pp. 3357-3364
    • Santhakumar, V.1    Hanchar, H.J.2    Wallner, M.3    Olsen, R.W.4    Otis, T.S.5
  • 60
    • 0027943698 scopus 로고
    • A receptor subunits: role of the δ subunit
    • A receptor subunits: role of the δ subunit. J. Neurosci. 14 (1994) 7077-7086
    • (1994) J. Neurosci. , vol.14 , pp. 7077-7086
    • Saxena, N.C.1    Macdonald, R.L.2
  • 61
    • 0037408550 scopus 로고    scopus 로고
    • GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    • Semyanov A., Walker M.C., and Kullmann D.M. GABA uptake regulates cortical excitability via cell type-specific tonic inhibition. Nat. Neurosci. 6 (2003) 484-490
    • (2003) Nat. Neurosci. , vol.6 , pp. 484-490
    • Semyanov, A.1    Walker, M.C.2    Kullmann, D.M.3
  • 62
    • 1942501006 scopus 로고    scopus 로고
    • Tonically active GABA(A) receptors: modulating gain and maintaining the tone
    • Semyanov A., Walker M.C., Kullmann D.M., and Silver R.A. Tonically active GABA(A) receptors: modulating gain and maintaining the tone. Trends Neurosci. 27 (2004) 262-269
    • (2004) Trends Neurosci. , vol.27 , pp. 262-269
    • Semyanov, A.1    Walker, M.C.2    Kullmann, D.M.3    Silver, R.A.4
  • 65
    • 0023160179 scopus 로고
    • Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study
    • Siggins G.R., Pittman Q.J., and French E.D. Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study. Brain Res. 414 (1987) 22-34
    • (1987) Brain Res. , vol.414 , pp. 22-34
    • Siggins, G.R.1    Pittman, Q.J.2    French, E.D.3
  • 66
    • 33645302360 scopus 로고    scopus 로고
    • Recent advances in Cys-loop receptor structure and function
    • Sine S.M., and Engel A.G. Recent advances in Cys-loop receptor structure and function. Nature 440 (2006) 448-455
    • (2006) Nature , vol.440 , pp. 448-455
    • Sine, S.M.1    Engel, A.G.2
  • 67
    • 33744485259 scopus 로고    scopus 로고
    • Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha, 5beta-THP: a possible model of premenstrual dysphoric disorder
    • Smith S.S., Ruderman Y., Frye C., Homanics G., and Yuan M. Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha, 5beta-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology (Berl) 186 (2006) 323-333
    • (2006) Psychopharmacology (Berl) , vol.186 , pp. 323-333
    • Smith, S.S.1    Ruderman, Y.2    Frye, C.3    Homanics, G.4    Yuan, M.5
  • 69
    • 0037095726 scopus 로고    scopus 로고
    • A conductances in hippocampal neurons
    • A conductances in hippocampal neurons. J. Neurosci. 22 (2002) RC223
    • (2002) J. Neurosci. , vol.22
    • Stell, B.M.1    Mody, I.2
  • 71
    • 0005208313 scopus 로고
    • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes
    • Suzdak P.D., Schwartz R.D., Skolnick P., and Paul S.M. Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 4071-4075
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 4071-4075
    • Suzdak, P.D.1    Schwartz, R.D.2    Skolnick, P.3    Paul, S.M.4
  • 72
    • 0024970431 scopus 로고
    • Ethanol and the benzodiazepine-GABA receptor-ionophore complex
    • Ticku M.K. Ethanol and the benzodiazepine-GABA receptor-ionophore complex. Experientia 45 (1989) 413-418
    • (1989) Experientia , vol.45 , pp. 413-418
    • Ticku, M.K.1
  • 73
    • 0028100310 scopus 로고
    • Reported alcohol use in women with premenstrual syndrome
    • Tobin M.B., Schmidt P.J., and Rubinow D.R. Reported alcohol use in women with premenstrual syndrome. Am. J. Psychiatry 151 (1994) 1503-1504
    • (1994) Am. J. Psychiatry , vol.151 , pp. 1503-1504
    • Tobin, M.B.1    Schmidt, P.J.2    Rubinow, D.R.3
  • 74
    • 33744459201 scopus 로고    scopus 로고
    • Nonsynaptic receptors for GABA and glutamate
    • Vizi E.S., and Mike A. Nonsynaptic receptors for GABA and glutamate. Curr. Top. Med. Chem. 6 (2006) 941-948
    • (2006) Curr. Top. Med. Chem. , vol.6 , pp. 941-948
    • Vizi, E.S.1    Mike, A.2
  • 77
    • 33749360596 scopus 로고    scopus 로고
    • Low dose acute alcohol effects on GABA A receptor subtypes
    • Wallner M., Hanchar H.J., and Olsen R.W. Low dose acute alcohol effects on GABA A receptor subtypes. Pharmacol. Ther. 112 (2006) 513-528
    • (2006) Pharmacol. Ther. , vol.112 , pp. 513-528
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 78
    • 4644326916 scopus 로고    scopus 로고
    • Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons
    • Wei W., Faria L.C., and Mody I. Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons. J. Neurosci. 24 (2004) 8379-8382
    • (2004) J. Neurosci. , vol.24 , pp. 8379-8382
    • Wei, W.1    Faria, L.C.2    Mody, I.3
  • 79
    • 0344442662 scopus 로고    scopus 로고
    • Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus
    • Wei W., Zhang N., Peng Z., Houser C.R., and Mody I. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23 (2003) 10650-10661
    • (2003) J. Neurosci. , vol.23 , pp. 10650-10661
    • Wei, W.1    Zhang, N.2    Peng, Z.3    Houser, C.R.4    Mody, I.5
  • 80
    • 33746734941 scopus 로고    scopus 로고
    • Ethanol modulation of GABAergic transmission: the view from the slice
    • Weiner J.L., and Valenzuela C.F. Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol. Ther. 111 (2006) 533-554
    • (2006) Pharmacol. Ther. , vol.111 , pp. 533-554
    • Weiner, J.L.1    Valenzuela, C.F.2
  • 82
    • 0038178996 scopus 로고    scopus 로고
    • GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?
    • Whiting P.J. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?. Drug Discov. Today 8 (2003) 445-450
    • (2003) Drug Discov. Today , vol.8 , pp. 445-450
    • Whiting, P.J.1
  • 83
    • 0026610272 scopus 로고
    • A single histidine in GABAA receptors is essential for benzodiazepine agonist binding
    • Wieland H.A., Luddens H., and Seeburg P.H. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267 (1992) 1426-1429
    • (1992) J. Biol. Chem. , vol.267 , pp. 1426-1429
    • Wieland, H.A.1    Luddens, H.2    Seeburg, P.H.3
  • 84
    • 0036522966 scopus 로고    scopus 로고
    • Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit
    • Wohlfarth K.M., Bianchi M.T., and Macdonald R.L. Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. J. Neurosci. 22 (2002) 1541-1549
    • (2002) J. Neurosci. , vol.22 , pp. 1541-1549
    • Wohlfarth, K.M.1    Bianchi, M.T.2    Macdonald, R.L.3
  • 85
    • 33751206507 scopus 로고    scopus 로고
    • The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters
    • Wu Y., Wang W., and Richerson G.B. The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters. J. Neurophysiol. 96 (2006) 2425-2436
    • (2006) J. Neurophysiol. , vol.96 , pp. 2425-2436
    • Wu, Y.1    Wang, W.2    Richerson, G.B.3
  • 86
    • 33749019747 scopus 로고    scopus 로고
    • Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors
    • Yamashita M., Marszalec W., Yeh J.Z., and Narahashi T. Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors. J. Pharmacol. Exp. Ther. 319 (2006) 431-438
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 431-438
    • Yamashita, M.1    Marszalec, W.2    Yeh, J.Z.3    Narahashi, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.