메뉴 건너뛰기




Volumn 41, Issue 3, 2007, Pages 155-162

Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results

Author keywords

Allosteric modulation; Delta subunit; Electrophysiology; Inhibitory neurotransmission; Ion channel; Xenopus oocyte

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BENZODIAZEPINE; DELTA OPIATE RECEPTOR; INHALATION ANESTHETIC AGENT; RECEPTOR SUBUNIT; ZINC;

EID: 34250788750     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2007.03.006     Document Type: Review
Times cited : (61)

References (48)
  • 1
    • 33746921639 scopus 로고    scopus 로고
    • delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol
    • Boehm II S.L., Homanics G.E., Blednov Y.A., and Harris R.A. delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. Eur. J. Pharmacol. 541 (2006) 158-162
    • (2006) Eur. J. Pharmacol. , vol.541 , pp. 158-162
    • Boehm II, S.L.1    Homanics, G.E.2    Blednov, Y.A.3    Harris, R.A.4
  • 3
    • 0036016217 scopus 로고    scopus 로고
    • Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression
    • Brandon N., Jovanovic J., and Moss S. Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression. Pharmacol. Ther. 94 (2002) 113-122
    • (2002) Pharmacol. Ther. , vol.94 , pp. 113-122
    • Brandon, N.1    Jovanovic, J.2    Moss, S.3
  • 4
    • 0036024231 scopus 로고    scopus 로고
    • Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors
    • Brown N., Kerby J., Bonnert T.P., Whiting P.J., and Wafford K.A. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br. J. Pharmacol. 136 (2002) 965-974
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 965-974
    • Brown, N.1    Kerby, J.2    Bonnert, T.P.3    Whiting, P.J.4    Wafford, K.A.5
  • 5
    • 33847220676 scopus 로고    scopus 로고
    • Only high concentrations of ethanol affect GABA(A) receptors of rat cerebellum granule cells in culture
    • Casagrande S., Cupello A., Pellistri F., and Robello M. Only high concentrations of ethanol affect GABA(A) receptors of rat cerebellum granule cells in culture. Neurosci. Lett. 414 (2007) 273-276
    • (2007) Neurosci. Lett. , vol.414 , pp. 273-276
    • Casagrande, S.1    Cupello, A.2    Pellistri, F.3    Robello, M.4
  • 6
    • 0031052341 scopus 로고    scopus 로고
    • Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit
    • Davies P.A., Hanna M.C., Hales T.G., and Kirkness E.F. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature 385 (1997) 820-823
    • (1997) Nature , vol.385 , pp. 820-823
    • Davies, P.A.1    Hanna, M.C.2    Hales, T.G.3    Kirkness, E.F.4
  • 7
    • 14844323722 scopus 로고    scopus 로고
    • Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    • Farrant M., and Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat. Rev. Neurosci. 6 (2005) 215-229
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 215-229
    • Farrant, M.1    Nusser, Z.2
  • 8
    • 0031451075 scopus 로고    scopus 로고
    • Single channel properties of recombinant GABAA receptors containing gamma 2 or delta subtypes expressed with alpha 1 and beta 3 subtypes in mouse L929 cells
    • Fisher J.L., and Macdonald R.L. Single channel properties of recombinant GABAA receptors containing gamma 2 or delta subtypes expressed with alpha 1 and beta 3 subtypes in mouse L929 cells. J. Physiol. 505 Pt 2 (1997) 283-297
    • (1997) J. Physiol. , vol.505 , Issue.PART 2 , pp. 283-297
    • Fisher, J.L.1    Macdonald, R.L.2
  • 9
    • 0032945358 scopus 로고    scopus 로고
    • GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts
    • Haas K.F., and Macdonald R.L. GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. J. Physiol. 514 Pt 1 (1999) 27-45
    • (1999) J. Physiol. , vol.514 , Issue.PART 1 , pp. 27-45
    • Haas, K.F.1    Macdonald, R.L.2
  • 10
    • 33744813823 scopus 로고    scopus 로고
    • Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors
    • Hanchar H.J., Chutsrinopkun P., Meera P., Supavilai P., Sieghart W., Wallner M., and Olsen R.W. Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. Proc. Natl. Acad. Sci. USA 103 (2006) 8546-8551
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8546-8551
    • Hanchar, H.J.1    Chutsrinopkun, P.2    Meera, P.3    Supavilai, P.4    Sieghart, W.5    Wallner, M.6    Olsen, R.W.7
  • 11
    • 33750978141 scopus 로고    scopus 로고
    • Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission
    • Hirzel K., Muller U., Latal A.T., Hulsmann S., Grudzinska J., Seeliger M.W., Betz H., and Laube B. Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52 (2006) 679-690
    • (2006) Neuron , vol.52 , pp. 679-690
    • Hirzel, K.1    Muller, U.2    Latal, A.T.3    Hulsmann, S.4    Grudzinska, J.5    Seeliger, M.W.6    Betz, H.7    Laube, B.8
  • 12
    • 0037381063 scopus 로고    scopus 로고
    • Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity
    • Hosie A.M., Dunne E.L., Harvey R.J., and Smart T.G. Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity. Nat. Neurosci. 6 (2003) 362-369
    • (2003) Nat. Neurosci. , vol.6 , pp. 362-369
    • Hosie, A.M.1    Dunne, E.L.2    Harvey, R.J.3    Smart, T.G.4
  • 13
    • 0032053437 scopus 로고    scopus 로고
    • Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits
    • Jechlinger M., Pelz R., Tretter V., Klausberger T., and Sieghart W. Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. J. Neurosci. 18 (1998) 2449-2457
    • (1998) J. Neurosci. , vol.18 , pp. 2449-2457
    • Jechlinger, M.1    Pelz, R.2    Tretter, V.3    Klausberger, T.4    Sieghart, W.5
  • 15
    • 0037154971 scopus 로고    scopus 로고
    • Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits
    • Korpi E.R., Mihalek R.M., Sinkkonen S.T., Hauer B., Hevers W., Homanics G.E., Sieghart W., and Luddens H. Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience 109 (2002) 733-743
    • (2002) Neuroscience , vol.109 , pp. 733-743
    • Korpi, E.R.1    Mihalek, R.M.2    Sinkkonen, S.T.3    Hauer, B.4    Hevers, W.5    Homanics, G.E.6    Sieghart, W.7    Luddens, H.8
  • 16
    • 3042818495 scopus 로고    scopus 로고
    • Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
    • Luscher B., and Keller C.A. Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol. Ther. 102 (2004) 195-221
    • (2004) Pharmacol. Ther. , vol.102 , pp. 195-221
    • Luscher, B.1    Keller, C.A.2
  • 19
    • 0028169077 scopus 로고
    • Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity
    • Mihic S.J., Whiting P.J., and Harris R.A. Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity. Eur. J. Pharmacol. 268 (1994) 209-214
    • (1994) Eur. J. Pharmacol. , vol.268 , pp. 209-214
    • Mihic, S.J.1    Whiting, P.J.2    Harris, R.A.3
  • 20
    • 0032589253 scopus 로고    scopus 로고
    • Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene
    • Nusser Z., Ahmad Z., Tretter V., Fuchs K., Wisden W., Sieghart W., and Somogyi P. Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. Eur. J. Neurosci. 11 (1999) 1685-1697
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 1685-1697
    • Nusser, Z.1    Ahmad, Z.2    Tretter, V.3    Fuchs, K.4    Wisden, W.5    Sieghart, W.6    Somogyi, P.7
  • 21
    • 0032008543 scopus 로고    scopus 로고
    • Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
    • Nusser Z., Sieghart W., and Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18 (1998) 1693-1703
    • (1998) J. Neurosci. , vol.18 , pp. 1693-1703
    • Nusser, Z.1    Sieghart, W.2    Somogyi, P.3
  • 22
    • 0037193041 scopus 로고    scopus 로고
    • GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain
    • Peng Z., Hauer B., Mihalek R.M., Homanics G.E., Sieghart W., Olsen R.W., and Houser C.R. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. J. Comp. Neurol. 446 (2002) 179-197
    • (2002) J. Comp. Neurol. , vol.446 , pp. 179-197
    • Peng, Z.1    Hauer, B.2    Mihalek, R.M.3    Homanics, G.E.4    Sieghart, W.5    Olsen, R.W.6    Houser, C.R.7
  • 23
    • 0034736184 scopus 로고    scopus 로고
    • GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain
    • Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., and Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101 (2000) 815-850
    • (2000) Neuroscience , vol.101 , pp. 815-850
    • Pirker, S.1    Schwarzer, C.2    Wieselthaler, A.3    Sieghart, W.4    Sperk, G.5
  • 24
    • 0037340216 scopus 로고    scopus 로고
    • Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit
    • Porcello D.M., Huntsman M.M., Mihalek R.M., Homanics G.E., and Huguenard J.R. Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. J. Neurophysiol. 89 (2003) 1378-1386
    • (2003) J. Neurophysiol. , vol.89 , pp. 1378-1386
    • Porcello, D.M.1    Huntsman, M.M.2    Mihalek, R.M.3    Homanics, G.E.4    Huguenard, J.R.5
  • 25
    • 0029967726 scopus 로고    scopus 로고
    • Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms
    • Saxena N.C., and Macdonald R.L. Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. Mol. Pharmacol. 49 (1996) 567-579
    • (1996) Mol. Pharmacol. , vol.49 , pp. 567-579
    • Saxena, N.C.1    Macdonald, R.L.2
  • 27
    • 0036673411 scopus 로고    scopus 로고
    • Subunit composition, distribution and function of GABA(A) receptor subtypes
    • Sieghart W., and Sperk G. Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr. Top. Med. Chem. 2 (2002) 795-816
    • (2002) Curr. Top. Med. Chem. , vol.2 , pp. 795-816
    • Sieghart, W.1    Sperk, G.2
  • 28
    • 4544236080 scopus 로고    scopus 로고
    • Zn2+ ions: modulators of excitatory and inhibitory synaptic activity
    • Smart T.G., Hosie A.M., and Miller P.S. Zn2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 10 (2004) 432-442
    • (2004) Neuroscientist , vol.10 , pp. 432-442
    • Smart, T.G.1    Hosie, A.M.2    Miller, P.S.3
  • 29
    • 0042817889 scopus 로고    scopus 로고
    • Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit
    • Spigelman I., Li Z., Liang J., Cagetti E., Samzadeh S., Mihalek R.M., Homanics G.E., and Olsen R.W. Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit. J. Neurophysiol. 90 (2003) 903-910
    • (2003) J. Neurophysiol. , vol.90 , pp. 903-910
    • Spigelman, I.1    Li, Z.2    Liang, J.3    Cagetti, E.4    Samzadeh, S.5    Mihalek, R.M.6    Homanics, G.E.7    Olsen, R.W.8
  • 30
    • 0344630208 scopus 로고    scopus 로고
    • Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    • Stell B.M., Brickley S.G., Tang C.Y., Farrant M., and Mody I. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc. Natl. Acad. Sci. USA 100 (2003) 14439-14444
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14439-14444
    • Stell, B.M.1    Brickley, S.G.2    Tang, C.Y.3    Farrant, M.4    Mody, I.5
  • 31
    • 33644772587 scopus 로고    scopus 로고
    • Pharmacological characterization of agonists at delta-containing GABAA receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2
    • Stórustovu S.I., and Ebert B. Pharmacological characterization of agonists at delta-containing GABAA receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2. J. Pharmacol. Exp. Ther. 316 (2006) 1351-1359
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , pp. 1351-1359
    • Stórustovu, S.I.1    Ebert, B.2
  • 32
    • 7944226960 scopus 로고    scopus 로고
    • Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells
    • Sun C., Sieghart W., and Kapur J. Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells. Brain Res. 1029 (2004) 207-216
    • (2004) Brain Res. , vol.1029 , pp. 207-216
    • Sun, C.1    Sieghart, W.2    Kapur, J.3
  • 35
    • 34250696686 scopus 로고    scopus 로고
    • Tang, X., and Macdonald, R.L. (2005). Modulation of alpha4beta3gamma2L and gamma4beta3delta GABA-A receptor channel currents by phosphorylation. Abstract Viewer/Itinerary Planner for the Society for Neuroscience Meeting. Program No. 262.17.
  • 36
    • 0036753724 scopus 로고    scopus 로고
    • Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics
    • Thompson S.A., Bonnert T.P., Cagetti E., Whiting P.J., and Wafford K.A. Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics. Neuropharmacology 43 (2002) 662-668
    • (2002) Neuropharmacology , vol.43 , pp. 662-668
    • Thompson, S.A.1    Bonnert, T.P.2    Cagetti, E.3    Whiting, P.J.4    Wafford, K.A.5
  • 37
    • 0032429608 scopus 로고    scopus 로고
    • Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit
    • Thompson S.A., Bonnert T.P., Whiting P.J., and Wafford K.A. Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit. Toxicol. Lett. 100-101 (1998) 233-238
    • (1998) Toxicol. Lett. , vol.100-101 , pp. 233-238
    • Thompson, S.A.1    Bonnert, T.P.2    Whiting, P.J.3    Wafford, K.A.4
  • 39
    • 0035971252 scopus 로고    scopus 로고
    • Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells
    • Tretter V., Hauer B., Nusser Z., Mihalek R.M., Hoger H., Homanics G.E., Somogyi P., and Sieghart W. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. J. Biol. Chem. 276 (2001) 10532-10538
    • (2001) J. Biol. Chem. , vol.276 , pp. 10532-10538
    • Tretter, V.1    Hauer, B.2    Nusser, Z.3    Mihalek, R.M.4    Hoger, H.5    Homanics, G.E.6    Somogyi, P.7    Sieghart, W.8
  • 40
    • 0036754274 scopus 로고    scopus 로고
    • GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons
    • Vicini S., Losi G., and Homanics G.E. GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. Neuropharmacology 43 (2002) 646-650
    • (2002) Neuropharmacology , vol.43 , pp. 646-650
    • Vicini, S.1    Losi, G.2    Homanics, G.E.3
  • 42
    • 0345598083 scopus 로고    scopus 로고
    • Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans
    • Wallner M., Hanchar H.J., and Olsen R.W. Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc. Natl. Acad. Sci. USA 100 (2003) 15218-15223
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15218-15223
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 43
    • 33749360596 scopus 로고    scopus 로고
    • Low dose acute alcohol effects on GABA(A) receptor subtypes
    • Wallner M., Hanchar H.J., and Olsen R.W. Low dose acute alcohol effects on GABA(A) receptor subtypes. Pharmacol. Ther. 112 (2006) 513-528
    • (2006) Pharmacol. Ther. , vol.112 , pp. 513-528
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 44
    • 0344442662 scopus 로고    scopus 로고
    • Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus
    • Wei W., Zhang N., Peng Z., Houser C.R., and Mody I. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23 (2003) 10650-10661
    • (2003) J. Neurosci. , vol.23 , pp. 10650-10661
    • Wei, W.1    Zhang, N.2    Peng, Z.3    Houser, C.R.4    Mody, I.5
  • 46
    • 16944362407 scopus 로고    scopus 로고
    • Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties
    • [corrected; erratum to be published]
    • Whiting P.J., McAllister G., Vassilatis D., Bonnert T.P., Heavens R.P., Smith D.W., Hewson L., O'Donnell R., Rigby M.R., Sirinathsinghji D.J., et al. Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties. [corrected; erratum to be published]. J. Neurosci. 17 (1997) 5027-5037
    • (1997) J. Neurosci. , vol.17 , pp. 5027-5037
    • Whiting, P.J.1    McAllister, G.2    Vassilatis, D.3    Bonnert, T.P.4    Heavens, R.P.5    Smith, D.W.6    Hewson, L.7    O'Donnell, R.8    Rigby, M.R.9    Sirinathsinghji, D.J.10
  • 48
    • 33749019747 scopus 로고    scopus 로고
    • Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors
    • Yamashita M., Marszalec W., Yeh J.Z., and Narahashi T. Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors. J. Pharmacol. Exp. Ther. 319 (2006) 431-438
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 431-438
    • Yamashita, M.1    Marszalec, W.2    Yeh, J.Z.3    Narahashi, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.